Cutting edge: Paracrine, but not autocrine, IL-2 signaling is sustained during early antiviral CD4 T cell response.
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A synaptic basis for paracrine interleukin-2 signaling during homotypic T cell interactionType I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection.Steady state dendritic cells present parenchymal self-antigen and contribute to, but are not essential for, tolerization of naive and Th1 effector CD4 cells.GFP affects human T cell activation and cytokine production following in vitro stimulation.Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction.CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation.Three-Dimensional Gradients of Cytokine Signaling between T Cells.Naive CD8+ T cells differentiate into protective memory-like cells after IL-2 anti IL-2 complex treatment in vivo.DUSP4 deficiency enhances CD25 expression and CD4+ T-cell proliferation without impeding T-cell development.IL-2 coordinates IL-2-producing and regulatory T cell interplay.T cells translate individual, quantal activation into collective, analog cytokine responses via time-integrated feedbacks.The roles of c-rel and interleukin-2 in tolerance: a molecular explanation of self-nonself discrimination.Regulatory T-cell homeostasis: steady-state maintenance and modulation during inflammation.Qualitatively different T cell phenotypic responses to IL-2 versus IL-15 are unified by identical dependences on receptor signal strength and duration.Control of Regulatory T Cell Migration, Function, and HomeostasisAdequate immune response ensured by binary IL-2 and graded CD25 expression in a murine transfer model.Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response.The initial phase of an immune response functions to activate regulatory T cells.CD134/CD137 dual costimulation-elicited IFN-γ maximizes effector T-cell function but limits Treg expansion.An Immunotherapeutic CD137 Agonist Releases Eomesodermin from ThPOK Repression in CD4 T Cells.Complete response to high-dose IL-2 and enhanced IFNγ+Th17 : TREG ratio in a melanoma patient.
P2860
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P2860
Cutting edge: Paracrine, but not autocrine, IL-2 signaling is sustained during early antiviral CD4 T cell response.
description
2006 nî lūn-bûn
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2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
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2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年论文
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name
Cutting edge: Paracrine, but n ...... antiviral CD4 T cell response.
@ast
Cutting edge: Paracrine, but n ...... antiviral CD4 T cell response.
@en
type
label
Cutting edge: Paracrine, but n ...... antiviral CD4 T cell response.
@ast
Cutting edge: Paracrine, but n ...... antiviral CD4 T cell response.
@en
prefLabel
Cutting edge: Paracrine, but n ...... antiviral CD4 T cell response.
@ast
Cutting edge: Paracrine, but n ...... antiviral CD4 T cell response.
@en
P2860
P1476
Cutting edge: Paracrine, but n ...... antiviral CD4 T cell response.
@en
P2093
Adam J Adler
Meixiao Long
P2860
P304
P356
10.4049/JIMMUNOL.177.7.4257
P407
P577
2006-10-01T00:00:00Z