Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response. - Wikidata - wikimedia - TriplyDB

Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response.

Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response.

http://www.wikidata.org/entity/Q41472662

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The 20th anniversary of interleukin-2 therapy: bimodal role explaining longstanding random induction of complete clinical responses Implications of Epigenetic Variability within a Cell Population for "Cell Type" Classification Heterogeneity in immune responses: from populations to single cells Daclizumab therapy for multiple sclerosis IL-2 sensitivity and exogenous IL-2 concentration gradient tune the productive contact duration of CD8(+) T cell-APC: a multiscale modeling study Understanding HIV latency: the road to an HIV cure Integrating signals from the T-cell receptor and the interleukin-2 receptor Exploring the contextual sensitivity of factors that determine cell-to-cell variability in receptor-mediated apoptosis Phosphorylation site dynamics of early T-cell receptor signaling Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells Rule-based multi-level modeling of cell biological systems The effects of interleukin-2 on immune response regulation.Polyfunctional responses by human T cells result from sequential release of cytokines.Desert ants achieve reliable recruitment across noisy interactions The efficacy and safety of daclizumab and its potential role in the treatment of multiple sclerosis.Stochastic sensitivity analysis and kernel inference via distributional data.A small-molecule c-Rel inhibitor reduces alloactivation of T cells without compromising antitumor activity Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy.An in silico modeling approach to understanding the dynamics of sarcoidosis Effector and naturally occurring regulatory T cells display no abnormalities in activation induced cell death in NOD mice A quantitative systems approach to identify paracrine mechanisms that locally suppress immune response to Interleukin-12 in the B16 melanoma model.Balancing speed and accuracy of polyclonal T cell activation: a role for extracellular feedback.Concurrent interaction of DCs with CD4(+) and CD8(+) T cells improves secondary CTL expansion: It takes three to tango.Systems modeling of molecular mechanisms controlling cytokine-driven CD4+ T cell differentiation and phenotype plasticity.Transcriptional regulation by nicotine in dopaminergic neurons.Mechanistic model of natural killer cell proliferative response to IL-15 receptor stimulation Social interaction in synthetic and natural microbial communities.Using an adaptive gene network model for self-organizing multicellular behavior.Sending mixed messages for cell population control.Foxp3⁺ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis.Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range.Single-cell RNA-seq reveals dynamic paracrine control of cellular variation.Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction.Central role for interleukin-2 in type 1 diabetes.Three-Dimensional Gradients of Cytokine Signaling between T Cells.PDE/ODE modeling and simulation to determine the role of diffusion in long-term and -range cellular signaling.T Cells Integrate Local and Global Cues to Discriminate between Structurally Similar Antigens Quorum-Sensing in CD4(+) T Cell Homeostasis: A Hypothesis and a Model.Design principles of cell circuits with paradoxical components.

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Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response.

http://www.wikidata.org/entity/Q41472662

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Single-cell quantification of ...... plasticity in immune response.

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Molecular Systems Biology

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Single-cell quantification of ...... plasticity in immune response.

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Garrit Jentsch

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Grégoire Altan-Bonnet

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Jesse W Coward

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Karen E Tkach

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Kendall A Smith

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Matthew M Hathorn

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Michael W Sneddon

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Ofer Feinerman

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P2860

Interleukin 2 regulates its own receptors

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: a new family of genes responsible for autoinducer production

Modeling T cell antigen discrimination based on feedback control of digital ERK responses

Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment

Mechanisms of foxp3+ T regulatory cell-mediated suppression

CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

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10.1038/MSB.2010.90

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6

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2010-11-01T00:00:00Z

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49647040

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21119631

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3010113

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