Sigma 1 receptor modulation of G-protein-coupled receptor signaling: potentiation of opioid transduction independent from receptor binding. - Wikidata - wikimedia - TriplyDB

Sigma 1 receptor modulation of G-protein-coupled receptor signaling: potentiation of opioid transduction independent from receptor binding.

Sigma 1 receptor modulation of G-protein-coupled receptor signaling: potentiation of opioid transduction independent from receptor binding.

http://www.wikidata.org/entity/Q33754837

about

Antagonists show GTP-sensitive high-affinity binding to the sigma-1 receptor Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers Crystal structure of the human σ1 receptor The oligomeric states of the purified sigma-1 receptor are stabilized by ligands.Sigma-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons Swimming against the tide: investigations of the C-bouton synapse.Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization.Safety, tolerability and pharmacokinetics of single and multiple doses of a novel sigma-1 receptor antagonist in three randomized phase I studies.The sigma-1 receptor chaperone as an inter-organelle signaling modulator Ethanol Stimulates Endoplasmic Reticulum Inositol Triphosphate and Sigma Receptors to Promote Withdrawal-Associated Loss of Neuron-Specific Nuclear Protein/Fox-3.Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons.Sigma-1 receptors and animal studies centered on pain and analgesia.The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems.Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats A Role for Sigma Receptors in Stimulant Self Administration and Addiction.(+)-Morphine attenuates the (-)-morphine-produced tail-flick inhibition via the sigma-1 receptor in the mouse spinal cord.Role of the Sigma-1 receptor in Amyotrophic Lateral Sclerosis (ALS)The sigma-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands Cyproheptadine enhances the I(K) of mouse cortical neurons through sigma-1 receptor-mediated intracellular signal pathway.Sigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin-remodeling factors at the nuclear envelope The lifetime of UDP-galactose:ceramide galactosyltransferase is controlled by a distinct endoplasmic reticulum-associated degradation (ERAD) regulated by sigma-1 receptor chaperones A role for sigma receptors in stimulant self-administration and addiction.Sigma receptors [σRs]: biology in normal and diseased states Mu opioids and their receptors: evolution of a concept.The sigma-1 receptor: a regulator of cancer cell electrical plasticity?Selective sigma-1 receptor antagonists for the treatment of pain.The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.Role of peripheral sigma-1 receptors in ischaemic pain: Potential interactions with ASIC and P2X receptors.Investigational sigma-1 receptor antagonists for the treatment of pain.Recent Advances in the Realm of Allosteric Modulators for Opioid Receptors for Future Therapeutics.Opioid adjuvant strategy: improving opioid effectiveness.Pharmacological Modulation of the Sigma 1 Receptor and the Treatment of Pain.Structural Insights into Sigma1 Function.Sigma-1 Receptor Antagonists: A New Class of Neuromodulatory Analgesics.Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice.Isolation and characterization of alternatively spliced variants of the mouse sigma1 receptor gene, Sigmar1.Development of the sigma-1 receptor in C-terminals of motoneurons and colocalization with the N,N'-dimethyltryptamine forming enzyme, indole-N-methyl transferase.Endocannabinoid control of glutamate NMDA receptors: the therapeutic potential and consequences of dysfunction.The σ1 receptor engages the redox-regulated HINT1 protein to bring opioid analgesia under NMDA receptor negative control.Allosteric Modulation of Opioid G-Protein Coupled Receptors by Sigma1 Receptors.

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P2860

Sigma 1 receptor modulation of G-protein-coupled receptor signaling: potentiation of opioid transduction independent from receptor binding.

http://www.wikidata.org/entity/Q33754837

description

2010 nî lūn-bûn

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2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Sigma 1 receptor modulation of ...... pendent from receptor binding.

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Sigma 1 receptor modulation of ...... pendent from receptor binding.

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Sigma 1 receptor modulation of ...... pendent from receptor binding.

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Sigma 1 receptor modulation of ...... pendent from receptor binding.

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Molecular Pharmacology

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Sigma 1 receptor modulation of ...... pendent from receptor binding.

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P2093

Chih-Cheng Chien

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Claire Neilan

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Felix J Kim

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Gavril W Pasternak

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Ivanka Kovalyshyn

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Maxim Burgman

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P2860

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1)

G-protein-coupled receptor heterodimerization modulates receptor function

Purification, molecular cloning, and expression of the mammalian sigma1-binding site

Membrane-delimited coupling between sigma receptors and K+ channels in rat neurohypophysial terminals requires neither G-protein nor ATP

Differentiation of sigma ligand-activated receptor subtypes that modulate NMDA-evoked [3H]-noradrenaline release in rat hippocampal slices

Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog

Potentiation of opioid analgesia in dopamine2 receptor knock-out mice: evidence for a tonically active anti-opioid system

Cellular regulation of RGS proteins: modulators and integrators of G protein signaling

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10.1124/MOL.109.057083

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4

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77

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2010-01-20T00:00:00Z

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41102254

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20089882

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G protein-coupled receptor

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2845939

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