The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma. - Wikidata - wikimedia - TriplyDB

The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.

The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.

http://www.wikidata.org/entity/Q33756262

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MYCN-2 Tet-on MYCN-3 Tet-on

P1343

Expression of the Bcl-3 proto-oncogene suppresses p53 activation Cell Proliferation in Neuroblastoma Neuroblastoma: oncogenic mechanisms and therapeutic exploitation of necroptosis Pou5f1/Oct4 promotes cell survival via direct activation of mych expression during zebrafish gastrulation Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma.Therapeutic aspects of c-MYC signaling in inflammatory and cancerous colonic diseases Functional Significance of Aurora Kinases-p53 Protein Family Interactions in Cancer Dickkopf-3 is regulated by the MYCN-induced miR-17-92 cluster in neuroblastoma Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination Therapeutic considerations for Mdm2: not just a one trick pony Global MYCN transcription factor binding analysis in neuroblastoma reveals association with distinct E-box motifs and regions of DNA hypermethylation.Unveiling MYCN regulatory networks in neuroblastoma via integrative analysis of heterogeneous genomics data.MDM2 SNP309 is associated with high grade node positive breast tumours and is in linkage disequilibrium with a novel MDM2 intron 1 polymorphism.A novel and universal method for microRNA RT-qPCR data normalization.TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer.Increased MIR31HG lncRNA expression increases gefitinib resistance in non-small cell lung cancer cell lines through the EGFR/PI3K/AKT signaling pathway.MYC interacts with the human STAGA coactivator complex via multivalent contacts with the GCN5 and TRRAP subunits.The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification Mdm2 links genotoxic stress and metabolism to p53.The p53 inhibitor MDM2 facilitates Sonic Hedgehog-mediated tumorigenesis and influences cerebellar foliation Co-localization of the oncogenic transcription factor MYCN and the DNA methyl binding protein MeCP2 at genomic sites in neuroblastoma.Myc proteins as therapeutic targets.Rapid establishment of a HEK 293 cell line expressing FVIII-BDD using AAV site-specific integration plasmids.Galectin-3 impairment of MYCN-dependent apoptosis-sensitive phenotype is antagonized by nutlin-3 in neuroblastoma cells Genetic regulators of large-scale transcriptional signatures in cancer.MycN promotes TRPM7 expression and cell migration in neuroblastoma through a process that involves polyamines.Zinc Finger 280B regulates sGCα1 and p53 in prostate cancer cells MDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cells Crosstalk between MYCN and MDM2-p53 signal pathways regulates tumor cell growth and apoptosis in neuroblastoma Focal adhesion kinase and p53 synergistically decrease neuroblastoma cell survival.An unexpected role for caspase-2 in neuroblastoma.Aurora B kinase is a potent and selective target in MYCN-driven neuroblastoma Syrbactin Structural Analog TIR-199 Blocks Proteasome Activity and Induces Tumor Cell Death.Transcription factor NFAT1 activates the mdm2 oncogene independent of p53.Molecular mechanisms of MYCN-dependent apoptosis and the MDM2-p53 pathway: an Achille's heel to be exploited for the therapy of MYCN-amplified neuroblastoma.Redefining functional MYCN gene signatures in neuroblastoma.MYCN controls an alternative RNA splicing program in high-risk metastatic neuroblastoma.Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels The MYCN oncogene is a direct target of miR-34a.Cell survival signaling in neuroblastoma.

P2860

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P1343

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P2860

The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.

http://www.wikidata.org/entity/Q33756262

description

2005 nî lūn-bûn

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2005 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2005 թվականի հունվարին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.

@ast

The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.

@en

type

label

The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.

@ast

The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.

@en

prefLabel

The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.

@ast

The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.

@en

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PNAS.0405495102

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma

@en

P2093

Andrew Slack

http://www.w3.org/2001/XMLSchema#string

Jason M Shohet

http://www.w3.org/2001/XMLSchema#string

Lisa Hunt

http://www.w3.org/2001/XMLSchema#string

Roberto Tonelli

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Zaowen Chen

http://www.w3.org/2001/XMLSchema#string

P2860

Nucleotide sequence of the human N-myc gene

Genomic targets of the human c-Myc protein

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

MDM2--master regulator of the p53 tumor suppressor protein

The Myc/Max/Mad network and the transcriptional control of cell behavior

Myc pathways provoking cell suicide and cancer

Posttranslational modification of MDM2

Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis

Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis

Bax accelerates tumorigenesis in p53-deficient mice.

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545522

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