Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. - Wikidata - wikimedia - TriplyDB

Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma.

Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma.

http://www.wikidata.org/entity/Q33756997

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Bromodomain Inhibitor Review: Bromodomain and Extra-terminal Family Protein Inhibitors as a Potential New Therapy in Central Nervous System Tumors Medulloblastoma stem cells: Promising targets in medulloblastoma therapy Bromodomains: Translating the words of lysine acetylation into myelin injury and repair An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression BRD4 inhibition suppresses cell growth, migration and invasion of salivary adenoid cystic carcinoma.Synergistic interactions between PLK1 and HDAC inhibitors in non-Hodgkin's lymphoma cells occur in vitro and in vivo and proceed through multiple mechanisms Synergistic induction of apoptosis by combination of BTK and dual mTORC1/2 inhibitors in diffuse large B cell lymphoma.The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers.The Bromodomain BET Inhibitor JQ1 Suppresses Tumor Angiogenesis in Models of Childhood Sarcoma Histone deacetylation contributes to low extracellular superoxide dismutase expression in human idiopathic pulmonary arterial hypertension.Targeting BET bromodomain proteins in solid tumors In vitro formation of neuroclusters in microfluidic devices and cell migration as a function of stromal-derived growth factor 1 gradients.Evolving molecular era of childhood medulloblastoma: time to revisit therapy.An epigenetic gateway to brain tumor cell identity.Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond.Epigenetics: A primer for clinicians.Targeting basal-like breast tumors with bromodomain and extraterminal domain (BET) and polo-like kinase inhibitors.Biological function and histone recognition of family IV bromodomain-containing proteins.BET bromodomain inhibitors synergize with ATR inhibitors to induce DNA damage, apoptosis, senescence-associated secretory pathway and ER stress in Myc-induced lymphoma cells.Structural features and inhibitors of bromodomains.Bromodomain and extraterminal protein inhibitors in pediatrics: A review of the literature.Bromodomain inhibitors and cancer therapy: From structures to applications.Medulloblastoma: Molecular Classification-Based Personal Therapeutics.Epigenetics and Cancer Stem Cells: Unleashing, Hijacking, and Restricting Cellular Plasticity.EGF as a New Therapeutic Target for Medulloblastoma Metastasis.MPS1 kinase as a potential therapeutic target in medulloblastoma.The PI3K Pathway in Human Disease.Combined inhibition of BET proteins and class I HDACs synergistically induces apoptosis in urothelial carcinoma cell lines.Targeting bromodomain and extraterminal proteins in breast cancer.JQ1 Induces DNA Damage and Apoptosis, and Inhibits Tumor Growth in a Patient-Derived Xenograft Model of Cholangiocarcinoma.Epigenetic regulation in medulloblastoma.Advances in Genomics Explain Medulloblastoma Behavior at the Bedside.BRD4 regulates cellular senescence in gastric cancer cells via E2F/miR-106b/p21 axis.Medulloblastoma in the Molecular Era.Mouse medulloblastoma driven by CRISPR activation of cellular Myc.Proteomic analysis of Medulloblastoma reveals functional biology with translational potential.

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P2860

Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma.

http://www.wikidata.org/entity/Q33756997

description

2014 nî lūn-bûn

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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2014 թվականի մայիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Inhibition of BRD4 attenuates ...... in MYC driven medulloblastoma.

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Inhibition of BRD4 attenuates ...... in MYC driven medulloblastoma.

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Inhibition of BRD4 attenuates ...... in MYC driven medulloblastoma.

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Inhibition of BRD4 attenuates ...... in MYC driven medulloblastoma.

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Inhibition of BRD4 attenuates ...... in MYC driven medulloblastoma.

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Inhibition of BRD4 attenuates ...... in MYC driven medulloblastoma.

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Inhibition of BRD4 attenuates ...... in MYC driven medulloblastoma

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Andrea Griesinger

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Brian Cristiano

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Diane K Birks

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Ilango Balakrishnan

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Irina Alimova

http://www.w3.org/2001/XMLSchema#string

Michael D Taylor

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Michael Handler

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Peter Harris

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Rajeev Vibhakar

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Sujatha Venkataraman

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P2860

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

Selective inhibition of BET bromodomains

Histone recognition and large-scale structural analysis of the human bromodomain family

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Discovery and characterization of small molecule inhibitors of the BET family bromodomains

Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

Identification of human brain tumour initiating cells

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

BET domain co-regulators in obesity, inflammation and cancer

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2355-2371

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scholarly article

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10.18632/ONCOTARGET.1659

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9

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5

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Nicholas K Foreman

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2014-05-01T00:00:00Z

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262073035

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24796395

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medulloblastoma

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4058011

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