Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes
about
AID and APOBECs span the gap between innate and adaptive immunityOptimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1Mutations, kataegis and translocations in B cells: understanding AID promiscuous activityEpigenetics of Peripheral B-Cell Differentiation and the Antibody ResponseRegulation of Aicda expression and AID activityTranscriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrityThe genetic landscape of diffuse large B-cell lymphomaRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationActivation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution.RNA Exosome Regulates AID DNA Mutator Activity in the B Cell GenomeConvergent transcription at intragenic super-enhancers targets AID-initiated genomic instabilityThe response to and repair of RAG-mediated DNA double-strand breaksc-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cellsRif1 prevents resection of DNA breaks and promotes immunoglobulin class switchingAID and Apobec3G haphazard deamination and mutational diversityProximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2.AID-induced remodeling of immunoglobulin genes and B cell fate.Generation and repair of AID-initiated DNA lesions in B lymphocytes.Binding of AID to DNA does not correlate with mutator activity.A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expressionRepression of human activation induced cytidine deaminase by miR-93 and miR-155.Replication protein A (RPA) hampers the processive action of APOBEC3G cytosine deaminase on single-stranded DNAThe cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centersClustered and genome-wide transient mutagenesis in human cancers: Hypermutation without permanent mutators or loss of fitnessRegulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.Identification of chromosomal translocation hotspots via scan statisticsNegative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis.The DNA glycosylases Ogg1 and Nth1 do not contribute to Ig class switching in activated mouse splenic B cells.R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters.The DSIF subunits Spt4 and Spt5 have distinct roles at various phases of immunoglobulin class switch recombinationRoles for histone H3K4 methyltransferase activities during immunoglobulin class-switch recombinationAID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells.Genome-wide detection of genes targeted by non-Ig somatic hypermutation in lymphomaSpt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo-activated cells.RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycleAID-initiated DNA lesions are differentially processed in distinct B cell populations.Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity.In vivo analysis of Aicda gene regulation: a critical balance between upstream enhancers and intronic silencers governs appropriate expression.The AID-induced DNA damage response in chromatin.B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.
P2860
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P2860
Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Deep-sequencing identification ...... cofactor RPA in B lymphocytes
@ast
Deep-sequencing identification ...... cofactor RPA in B lymphocytes
@en
type
label
Deep-sequencing identification ...... cofactor RPA in B lymphocytes
@ast
Deep-sequencing identification ...... cofactor RPA in B lymphocytes
@en
prefLabel
Deep-sequencing identification ...... cofactor RPA in B lymphocytes
@ast
Deep-sequencing identification ...... cofactor RPA in B lymphocytes
@en
P2093
P2860
P50
P356
P1433
P1476
Deep-sequencing identification ...... cofactor RPA in B lymphocytes
@en
P2093
Hong-wei Sun
Kevin McBride
Michel C Nussenzweig
Rafael Casellas
Wolfgang Resch
P2860
P356
10.1038/NI.1964
P407
P577
2010-11-28T00:00:00Z