Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes - Wikidata - wikimedia - TriplyDB

Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes

Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes

http://www.wikidata.org/entity/Q33757410

about

AID and APOBECs span the gap between innate and adaptive immunity Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1 Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity Epigenetics of Peripheral B-Cell Differentiation and the Antibody Response Regulation of Aicda expression and AID activity Transcriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrity The genetic landscape of diffuse large B-cell lymphoma Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination Activation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution.RNA Exosome Regulates AID DNA Mutator Activity in the B Cell Genome Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability The response to and repair of RAG-mediated DNA double-strand breaks c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching AID and Apobec3G haphazard deamination and mutational diversity Proximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2.AID-induced remodeling of immunoglobulin genes and B cell fate.Generation and repair of AID-initiated DNA lesions in B lymphocytes.Binding of AID to DNA does not correlate with mutator activity.A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression Repression of human activation induced cytidine deaminase by miR-93 and miR-155.Replication protein A (RPA) hampers the processive action of APOBEC3G cytosine deaminase on single-stranded DNA The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers Clustered and genome-wide transient mutagenesis in human cancers: Hypermutation without permanent mutators or loss of fitness Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.Identification of chromosomal translocation hotspots via scan statistics Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis.The DNA glycosylases Ogg1 and Nth1 do not contribute to Ig class switching in activated mouse splenic B cells.R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters.The DSIF subunits Spt4 and Spt5 have distinct roles at various phases of immunoglobulin class switch recombination Roles for histone H3K4 methyltransferase activities during immunoglobulin class-switch recombination AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells.Genome-wide detection of genes targeted by non-Ig somatic hypermutation in lymphoma Spt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo-activated cells.RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycle AID-initiated DNA lesions are differentially processed in distinct B cell populations.Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity.In vivo analysis of Aicda gene regulation: a critical balance between upstream enhancers and intronic silencers governs appropriate expression.The AID-induced DNA damage response in chromatin.B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.

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Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes

http://www.wikidata.org/entity/Q33757410

description

2010 nî lūn-bûn

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2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Deep-sequencing identification ...... cofactor RPA in B lymphocytes

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Deep-sequencing identification ...... cofactor RPA in B lymphocytes

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type

label

Deep-sequencing identification ...... cofactor RPA in B lymphocytes

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Deep-sequencing identification ...... cofactor RPA in B lymphocytes

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prefLabel

Deep-sequencing identification ...... cofactor RPA in B lymphocytes

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Deep-sequencing identification ...... cofactor RPA in B lymphocytes

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Nature Immunology

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Deep-sequencing identification ...... cofactor RPA in B lymphocytes

@en

P2093

Hong-wei Sun

http://www.w3.org/2001/XMLSchema#string

Kevin McBride

http://www.w3.org/2001/XMLSchema#string

Michel C Nussenzweig

http://www.w3.org/2001/XMLSchema#string

Nan Kuo

http://www.w3.org/2001/XMLSchema#string

Rafael Casellas

http://www.w3.org/2001/XMLSchema#string

Wolfgang Resch

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Zhiyu Li

http://www.w3.org/2001/XMLSchema#string

P2860

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

Reprogramming towards pluripotency requires AID-dependent DNA demethylation

c-Myc regulates transcriptional pause release

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

High-resolution profiling of histone methylations in the human genome

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism

Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

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62-69

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10.1038/NI.1964

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P433

1

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12

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2010-11-28T00:00:00Z

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49640996

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21113164

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3005028

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