A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression
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Out of balance: R-loops in human diseaseInhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer TherapyBreaking bad: R-loops and genome integrityReplication and transcription on a collision course: eukaryotic regulation mechanisms and implications for DNA stabilityTranscriptional termination in mammals: Stopping the RNA polymerase II juggernautNon-coding RNA in neural function, disease, and agingG-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptomeRNA Exosome Regulates AID DNA Mutator Activity in the B Cell GenomeEvolution of the Antisense Overlap between Genes for Thyroid Hormone Receptor and Rev-erbα and Characterization of an Exonic G-Rich Element That Regulates Splicing of TRα2 mRNABiological Processes Discovered by High-Throughput Sequencing.Production of Extrachromosomal MicroDNAs Is Linked to Mismatch Repair Pathways and Transcriptional ActivitySsb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress.Genome-wide distribution of RNA-DNA hybrids identifies RNase H targets in tRNA genes, retrotransposons and mitochondriaTranscription-coupled nucleotide excision repair factors promote R-loop-induced genome instabilityBRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair.End of the beginning: elongation and termination features of alternative modes of chromosomal replication initiation in bacteriaRole for RNA:DNA hybrids in origin-independent replication priming in a eukaryotic system.RNase HI Is Essential for Survival of Mycobacterium smegmatis.Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo.Large expansion of CTG•CAG repeats is exacerbated by MutSβ in human cells.Flap Endonuclease 1 Limits Telomere Fragility on the Leading StrandThe Fanconi Anemia Pathway Protects Genome Integrity from R-loops.The Yin and Yang of R-loop biology.Regulated Formation of lncRNA-DNA Hybrids Enables Faster Transcriptional Induction and Environmental Adaptation.Friedreich's ataxia--a case of aberrant transcription termination?Emerging role of RNA•DNA hybrids in C9orf72-linked neurodegeneration.The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing.The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription.Preferential expression of scores of functionally and evolutionarily diverse DNA and RNA-binding proteins during Oxytricha trifallax macronuclear development.RNA:DNA hybrids in the human genome have distinctive nucleotide characteristics, chromatin composition, and transcriptional relationships.Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1R loops regulate promoter-proximal chromatin architecture and cellular differentiation.Structural basis for suppression of hypernegative DNA supercoiling by E. coli topoisomerase ITranscriptional elongation requires DNA break-induced signalling.The spliceosome-associated protein Nrl1 suppresses homologous recombination-dependent R-loop formation in fission yeast.Diverse regulatory interactions of long noncoding RNAs.Prevalent, Dynamic, and Conserved R-Loop Structures Associate with Specific Epigenomic Signatures in Mammals.Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage.Single molecule identification of homology-dependent interactions between long ssRNA and dsDNA.Lineage-Specific Genes Are Prominent DNA Damage Hotspots during Leukemic Transformation of B Cell Precursors.
P2860
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P2860
A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression
description
2014 nî lūn-bûn
@nan
2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
A double-edged sword: R loops ...... regulators of gene expression
@ast
A double-edged sword: R loops ...... regulators of gene expression
@en
type
label
A double-edged sword: R loops ...... regulators of gene expression
@ast
A double-edged sword: R loops ...... regulators of gene expression
@en
prefLabel
A double-edged sword: R loops ...... regulators of gene expression
@ast
A double-edged sword: R loops ...... regulators of gene expression
@en
P2860
P356
P1433
P1476
A double-edged sword: R loops ...... regulators of gene expression
@en
P2093
Konstantina Skourti-Stathaki
P2860
P304
P356
10.1101/GAD.242990.114
P577
2014-07-01T00:00:00Z