Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. - Wikidata - wikimedia - TriplyDB

Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.

Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.

http://www.wikidata.org/entity/Q33757944

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Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers Hypoxia-inducible factors and the response to hypoxic stress Compensatory angiogenesis and tumor refractoriness PHD2: from hypoxia regulation to disease progression Prolyl hydroxylase-2 (PHD2) exerts tumor-suppressive activity in pancreatic cancer Prolyl hydroxylase domain 2 protein is a strong prognostic marker in human gastric cancer Antimycotic ciclopirox olamine in the diabetic environment promotes angiogenesis and enhances wound healing The role of PHD2 mutations in the pathogenesis of erythrocytosis.Prolyl-4-hydroxylase domain protein 2 controls NF-κB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus.HIF-1α activation results in actin cytoskeleton reorganization and modulation of Rac-1 signaling in endothelial cells Endothelin-1 inhibits prolyl hydroxylase domain 2 to activate hypoxia-inducible factor-1alpha in melanoma cells.Human bone marrow mesenchymal stem cells display anti-cancer activity in SCID mice bearing disseminated non-Hodgkin's lymphoma xenografts Comparison of genomics and functional imaging from canine sarcomas treated with thermoradiotherapy predicts therapeutic response and identifies combination therapeutics.The function of hypoxia-inducible factor (HIF) is independent of the endoplasmic reticulum protein OS-9 Overexpression of the HIF hydroxylases PHD1, PHD2, PHD3 and FIH are individually and collectively unfavorable prognosticators for NSCLC survival Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice.Suppression of glioma progression by Egln3 The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapy Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR.Angiogenin secretion from hepatoma cells activates hepatic stellate cells to amplify a self-sustained cycle promoting liver cancer.Genetic targeting of sprouting angiogenesis using Apln-CreER.The prolyl hydroxylase enzymes are positively associated with hypoxia-inducible factor-1α and vascular endothelial growth factor in human breast cancer and alter in response to primary systemic treatment with epirubicin and tamoxifen.HIF-1α restricts NF-κB-dependent gene expression to control innate immunity signals Epidermal or dermal specific knockout of PHD-2 enhances wound healing and minimizes ischemic injury.Knockout of mitochondrial thioredoxin reductase stabilizes prolyl hydroxylase 2 and inhibits tumor growth and tumor-derived angiogenesis.Analysis of HIF-1a and its regulator, PHD2, in retroperitoneal sarcomas: clinico-pathologic implications.HEXIM1 down-regulates hypoxia-inducible factor-1α protein stability.Distinct deregulation of the hypoxia inducible factor by PHD2 mutants identified in germline DNA of patients with polycythemia Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling.Role of the nuclear receptor coactivator AIB1/SRC-3 in angiogenesis and wound healing.Cnidium officinale extract and butylidenephthalide inhibits retinal neovascularization in vitro and in vivo Targeting chemokine pathways in esophageal adenocarcinoma.Genome-independent hypoxic repression of estrogen receptor alpha in breast cancer cells.Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis.Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma.The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses Inhibition of metastasis by HEXIM1 through effects on cell invasion and angiogenesis.Distinct breast cancer stem/progenitor cell populations require either HIF1α or loss of PHD3 to expand under hypoxic conditions

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Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.

http://www.wikidata.org/entity/Q33757944

description

2009 nî lūn-bûn

@nan

2009 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հունիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Tumor vasculature is regulated ...... rrow-derived cell recruitment.

@ast

Tumor vasculature is regulated ...... rrow-derived cell recruitment.

@en

type

label

Tumor vasculature is regulated ...... rrow-derived cell recruitment.

@ast

Tumor vasculature is regulated ...... rrow-derived cell recruitment.

@en

prefLabel

Tumor vasculature is regulated ...... rrow-derived cell recruitment.

@ast

Tumor vasculature is regulated ...... rrow-derived cell recruitment.

@en

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J.CCR.2009.04.010

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Tumor vasculature is regulated ...... rrow-derived cell recruitment.

@en

P2093

Amato J Giaccia

http://www.w3.org/2001/XMLSchema#string

Denise A Chan

http://www.w3.org/2001/XMLSchema#string

Howard Y Chang

http://www.w3.org/2001/XMLSchema#string

Jen-Tsan Chi

http://www.w3.org/2001/XMLSchema#string

Patrick D Sutphin

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Tiara L A Kawahara

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P2860

The Hallmarks of Cancer

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts.

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527-538

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10.1016/J.CCR.2009.04.010

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6

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15

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26248643

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19477431

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2846696

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