A dynamic model of HIV integrase inhibition and drug resistance.
about
Designing modulators of monoamine transporters using virtual screening techniquesBlind prediction of HIV integrase binding from the SAMPL4 challengeLigand Access to the Active Site in Thermus thermophilus ba 3 and Bovine Heart aa 3 Cytochrome OxidasesStructural Basis of Mos1 Transposase Inhibition by the Anti-retroviral Drug RaltegravirStructure-analysis of the HIV-1 integrase Y143C/R raltegravir resistance mutation in association with the secondary mutation T97AOroxylin A inhibits hemolysis via hindering the self-assembly of α-hemolysin heptameric transmembrane poreVirtual screening of integrase inhibitors by large scale binding free energy calculations: the SAMPL4 challenge.Bicyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.Structure-based modeling of the functional HIV-1 intasome and its inhibitionComputer-aided drug-discovery techniques that account for receptor flexibility.Molecular recognition in the case of flexible targets.Probing chelation motifs in HIV integrase inhibitorsBicyclic 1-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-containing HIV-1 integrase inhibitors having high antiviral potency against cells harboring raltegravir-resistant integrase mutants.Biomolecularmodeling and simulation: a field coming of age.Molecular dynamics of HIV1-integrase in complex with 93del - a structural perspective on the mechanism of inhibition.Virtual screening with AutoDock Vina and the common pharmacophore engine of a low diversity library of fragments and hits against the three allosteric sites of HIV integrase: participation in the SAMPL4 protein-ligand binding challengeFisetin inhibits Listeria monocytogenes virulence by interfering with the oligomerization of listeriolysin O.Molecular dynamics simulation studies of the wild type and E92Q/N155H mutant of Elvitegravir-resistance HIV-1 integrase.Molecular dynamics simulation studies of the wild type and E92Q/N155H mutant of Elvitegravir-resistance HIV-1 integrase.Stabilization of the integrase-DNA complex by Mg2+ ions and prediction of key residues for binding HIV-1 integrase inhibitors.Raltegravir flexibility and its impact on recognition by the HIV-1 IN targets.Study on the interactions between diketo-acid inhibitors and prototype foamy virus integrase-DNA complex via molecular docking and comparative molecular dynamics simulation methods.Understanding the effect of drug-resistant mutations of HIV-1 intasome on raltegravir action through molecular modeling study.
P2860
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P2860
A dynamic model of HIV integrase inhibition and drug resistance.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
name
A dynamic model of HIV integrase inhibition and drug resistance.
@ast
A dynamic model of HIV integrase inhibition and drug resistance.
@en
type
label
A dynamic model of HIV integrase inhibition and drug resistance.
@ast
A dynamic model of HIV integrase inhibition and drug resistance.
@en
prefLabel
A dynamic model of HIV integrase inhibition and drug resistance.
@ast
A dynamic model of HIV integrase inhibition and drug resistance.
@en
P2093
P2860
P1476
A dynamic model of HIV integrase inhibition and drug resistance.
@en
P2093
Alex L Perryman
Arthur J Olson
Catherine Burt
Chris Phillips
Kevin Whitby
Michael J Palmer
Stefano Forli
Yuhui Cheng
P2860
P304
P356
10.1016/J.JMB.2010.01.033
P577
2010-01-22T00:00:00Z