Systematic dissection and trajectory-scanning mutagenesis of the molecular interface that ensures specificity of two-component signaling pathways. - Wikidata - wikimedia - TriplyDB

Systematic dissection and trajectory-scanning mutagenesis of the molecular interface that ensures specificity of two-component signaling pathways.

Systematic dissection and trajectory-scanning mutagenesis of the molecular interface that ensures specificity of two-component signaling pathways.

http://www.wikidata.org/entity/Q33760819

about

Prokaryotic 2-component systems and the OmpR/PhoB superfamily Negative control in two-component signal transduction by transmitter phosphatase activity Cell fate regulation governed by a repurposed bacterial histidine kinase Structural insights into ChpT, an essential dimeric histidine phosphotransferase regulating the cell cycle inCaulobacter crescentus Structural Basis of a Rationally Rewired Protein-Protein Interface Critical to Bacterial Signaling Temporal and evolutionary dynamics of two-component signaling pathways Genetic and biochemical dissection of a HisKA domain identifies residues required exclusively for kinase and phosphatase activities The two-component sensor KinB acts as a phosphatase to regulate Pseudomonas aeruginosa Virulence Covariation Is a Poor Measure of Molecular Coevolution.A Variable Active Site Residue Influences the Kinetics of Response Regulator Phosphorylation and Dephosphorylation.Eubacterial SpoVG homologs constitute a new family of site-specific DNA-binding proteins.Evolution of two-component signal transduction systems Crosstalk and the evolution of specificity in two-component signaling Antibiotic modulation of capsular exopolysaccharide and virulence in Acinetobacter baumannii Conservation weighting functions enable covariance analyses to detect functionally important amino acids.Determinants of homodimerization specificity in histidine kinases.Protein evolution. Pervasive degeneracy and epistasis in a protein-protein interface.A specificity determinant for phosphorylation in a response regulator prevents in vivo cross-talk and modification by acetyl phosphate.The Eukaryotic-Like Ser/Thr Kinase PrkC Regulates the Essential WalRK Two-Component System in Bacillus subtilis Structural asymmetry in a conserved signaling system that regulates division, replication, and virulence of an intracellular pathogen.The orphan response regulator EpsW is a substrate of the DifE kinase and it regulates exopolysaccharide in Myxococcus xanthus.Engineering robust control of two-component system phosphotransfer using modular scaffolds.Intramolecular arrangement of sensor and regulator overcomes relaxed specificity in hybrid two-component systems.Missense substitutions reflecting regulatory control of transmitter phosphatase activity in two-component signalling Design of orthogonal genetic switches based on a crosstalk map of σs, anti-σs, and promoters.Connecting the Sequence-Space of Bacterial Signaling Proteins to Phenotypes Using Coevolutionary Landscapes.Dynamics and activation in response regulators: the β4-α4 loop The MprB extracytoplasmic domain negatively regulates activation of the Mycobacterium tuberculosis MprAB two-component system.Toward rationally redesigning bacterial two-component signaling systems using coevolutionary information.The functional importance of co-evolving residues in proteins.Stress-induced remodeling of the bacterial proteome.Engineering allostery.The orphan histidine protein kinase SgmT is a c-di-GMP receptor and regulates composition of the extracellular matrix together with the orphan DNA binding response regulator DigR in Myxococcus xanthus.In Vivo Characterization of the Activation and Interaction of the VanR-VanS Two-Component Regulatory System Controlling Glycopeptide Antibiotic Resistance in Two Related Streptomyces Species.A novel streptococcal cell-cell communication peptide promotes pneumococcal virulence and biofilm formation.Cross-talk and specificity in two-component signal transduction pathways.Discrimination and Integration of Stress Signals by Pathogenic Bacteria.Spatial tethering of kinases to their substrates relaxes evolutionary constraints on specificity.Functional Dissection of the CroRS Two-Component System Required for Resistance to Cell Wall Stressors in Enterococcus faecalis.Involvement of WalK (VicK) phosphatase activity in setting WalR (VicR) response regulator phosphorylation level and limiting cross-talk in Streptococcus pneumoniae D39 cells.

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Systematic dissection and trajectory-scanning mutagenesis of the molecular interface that ensures specificity of two-component signaling pathways.

http://www.wikidata.org/entity/Q33760819

description

2010 nî lūn-bûn

@nan

2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Systematic dissection and traj ...... -component signaling pathways.

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Systematic dissection and traj ...... -component signaling pathways.

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type

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Systematic dissection and traj ...... -component signaling pathways.

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Systematic dissection and traj ...... -component signaling pathways.

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Systematic dissection and traj ...... -component signaling pathways.

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Systematic dissection and traj ...... -component signaling pathways.

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Systematic dissection and traj ...... -component signaling pathways.

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Barrett S Perchuk

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Emily J Capra

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Emma A Lubin

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Jeffrey M Skerker

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Michael T Laub

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Orr Ashenberg

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P2860

Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis

Crystal structure of an ancient protein: evolution by conformational epistasis

An epistatic ratchet constrains the direction of glucocorticoid receptor evolution

Structural insight into partner specificity and phosphoryl transfer in two-component signal transduction

Using Structural Information to Change the Phosphotransfer Specificity of a Two-Component Chemotaxis Signalling Complex

Two-component signal transduction

Identification of direct residue contacts in protein-protein interaction by message passing

Java Treeview--extensible visualization of microarray data

Open source clustering software

Darwinian evolution can follow only very few mutational paths to fitter proteins

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11

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6

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