Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells.
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Role of endoplasmic reticulum stress in drug-induced toxicityAcetaminophen-induced Liver Injury: from Animal Models to HumansThe hepatocyte proteome in organotypic rat liver models and the influence of the local microenvironment.Treatment of mouse liver slices with cholestatic hepatotoxicants results in down-regulation of Fxr and its target genesRapid differentiation of in vitro cellular responses to toxic chemicals by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.S-adenosyl-l-methionine protection of acetaminophen mediated oxidative stress and identification of hepatic 4-hydroxynonenal protein adducts by mass spectrometryCyclosporin A induced toxicity in mouse liver slices is only slightly aggravated by Fxr-deficiency and co-occurs with upregulation of pro-inflammatory genes and downregulation of genes involved in mitochondrial functions.Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Cytotoxicity and apoptosis induced by a plumbagin derivative in estrogen positive MCF-7 breast cancer cellsProteomic Workflows for Biomarker Identification Using Mass Spectrometry - Technical and Statistical Considerations during Initial Discovery.Review article: Drug-induced liver injury--its pathophysiology and evolving diagnostic tools.Using metalloproteomics to investigate the cellular physiology of copper in hepatocytes.Latest advances in predicting DILI in human subjects: focus on biomarkers.Proteomics in mechanistic toxicology: history, concepts, achievements, caveats, and potential.Competency of different cell models to predict human hepatotoxic drugs.Proteomics for systems toxicology.An integrated proteomic and transcriptomic approach to understanding azathioprine- induced hepatotoxicity in rat primary hepatocytes.Exposure of CCRF-CEM cells to acridone derivative 8a triggers tumor death via multiple mechanisms.Tris(2-chloroethyl)phosphate-induced cell growth arrest via attenuation of SIRT1-independent PI3K/Akt/mTOR pathway.Different dose-dependent mechanisms are involved in early cyclosporine a-induced cholestatic effects in hepaRG cells.Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiationScreening for drug-induced hepatotoxicity in primary mouse hepatocytes using acetaminophen, amiodarone, and cyclosporin a as model compounds: an omics-guided approach.AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells.Acetaminophen-Induced Liver Injury Alters the Acyl Ethanolamine-Based Anti-Inflammatory Signaling System in Liver.Editor's Highlight: Mechanistic Toxicity Tests Based on an Adverse Outcome Pathway Network for Hepatic Steatosis.LC-MS untargeted metabolomic analysis of drug-induced hepatotoxicity in HepG2 cells.Toward Correlation in In Vivo and In Vitro Nanotoxicology StudiesHigh-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins
P2860
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P2860
Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells.
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells.
@ast
Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells.
@en
type
label
Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells.
@ast
Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells.
@en
prefLabel
Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells.
@ast
Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells.
@en
P2093
P2860
P356
P1476
Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells.
@en
P2093
Anke Van Summeren
Edwin C M Mariman
Freek G Bouwman
Jean-Paul Noben
Johan Renes
Joost H M van Delft
Jos C S Kleinjans
P2860
P304
P356
10.1093/TOXSCI/KFQ380
P577
2010-12-16T00:00:00Z