Different dose-dependent mechanisms are involved in early cyclosporine a-induced cholestatic effects in hepaRG cells.
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Role of endoplasmic reticulum stress in drug-induced toxicityRho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs.A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophenPenicillinase-resistant antibiotics induce non-immune-mediated cholestasis through HSP27 activation associated with PKC/P38 and PI3K/AKT signaling pathwaysCyclosporin A induced toxicity in mouse liver slices is only slightly aggravated by Fxr-deficiency and co-occurs with upregulation of pro-inflammatory genes and downregulation of genes involved in mitochondrial functions.Bile Acid-Induced Toxicity in HepaRG Cells Recapitulates the Response in Primary Human HepatocytesComparative Localization and Functional Activity of the Main Hepatobiliary Transporters in HepaRG Cells and Primary Human Hepatocytes.Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability.Low-dose acetaminophen induces early disruption of cell-cell tight junctions in human hepatic cells and mouse liver.Cellular Accumulation and Toxic Effects of Bile Acids in Cyclosporine A-Treated HepaRG Hepatocytes.Editor's Highlight: Characterization of Hepatotoxicity Mechanisms Triggered by Designer Cathinone Drugs (β-Keto Amphetamines).A Dynamic Mathematical Model of Bile Acid Clearance in HepaRG Cells.From the Cover: MechanisticInsights in Cytotoxic and Cholestatic Potential of the Endothelial Receptor Antagonists Using HepaRG Cells.Early Alterations of Bile Canaliculi Dynamics and the Rho Kinase/Myosin Light Chain Kinase Pathway Are Characteristics of Drug-Induced Intrahepatic Cholestasis.UEG Week 2015 Poster Presentations
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P2860
Different dose-dependent mechanisms are involved in early cyclosporine a-induced cholestatic effects in hepaRG cells.
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2014 nî lūn-bûn
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2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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name
Different dose-dependent mecha ...... tatic effects in hepaRG cells.
@en
type
label
Different dose-dependent mecha ...... tatic effects in hepaRG cells.
@en
prefLabel
Different dose-dependent mecha ...... tatic effects in hepaRG cells.
@en
P2093
P2860
P356
P1476
Different dose-dependent mecha ...... tatic effects in hepaRG cells.
@en
P2093
Ahmad Sharanek
André Guillouzo
Camille C Savary
Christiane Guguen-Guillouzo
Dominique Rainteau
Houssein Al-Attrache
Lydie Humbert
Pamela Bachour-El Azzi
P2860
P304
P356
10.1093/TOXSCI/KFU122
P577
2014-06-27T00:00:00Z