Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B cells through a PI3-kinase-dependent pathway.
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Tetraspanin CD37 directly mediates transduction of survival and apoptotic signalsLenalidomide and chronic lymphocytic leukemiaImmune reconstitution in chronic lymphocytic leukemiaImmunomodulatory drugs and active immunotherapy for chronic lymphocytic leukemiaSelective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemiaTherapeutic potential and challenges of targeting receptor tyrosine kinase ROR1 with monoclonal antibodies in B-cell malignanciesp73 as a pharmaceutical target for cancer therapyA phase I study of lenalidomide in combination with fludarabine and rituximab in previously untreated CLL/SLL.Safety and efficacy of different lenalidomide starting doses in patients with relapsed or refractory chronic lymphocytic leukemia: results of an international multicenter double-blinded randomized phase II trial.Lenalidomide and rituximab for the initial treatment of patients with chronic lymphocytic leukemia: a multicenter clinical-translational study from the chronic lymphocytic leukemia research consortium.Molecular targets for selective killing of TRAIL-resistant leukemic cells.Modern treatment in chronic lymphocytic leukemia: impact on survival and efficacy in high-risk subgroupsLenalidomide induces long-lasting responses in elderly patients with chronic lymphocytic leukemiaLenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia.Lenalidomide inhibits the proliferation of CLL cells via a cereblon/p21(WAF1/Cip1)-dependent mechanism independent of functional p53The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor.Dose escalation of lenalidomide in relapsed or refractory acute leukemias.Restricted cell surface expression of receptor tyrosine kinase ROR1 in pediatric B-lineage acute lymphoblastic leukemia suggests targetability with therapeutic monoclonal antibodies.Transplantation in chronic lymphocytic leukemia: does it still matter in the era of novel targeted therapies?The role of phosphatidylinositol 3-kinase-δ in the immunomodulatory effects of lenalidomide in chronic lymphocytic leukemia.Treatment with lenalidomide modulates T-cell immunophenotype and cytokine production in patients with chronic lymphocytic leukemiaHow much? How frequent? How long? A clinical guide to new therapies in myelodysplastic syndromesSpontaneous Immunity Against the Receptor Tyrosine Kinase ROR1 in Patients with Chronic Lymphocytic Leukemia.Initial testing of lenalidomide by the pediatric preclinical testing programTargeting malignant B cells with an immunotoxin against ROR1RhoH is critical for cell-microenvironment interactions in chronic lymphocytic leukemia in mice and humans.Genome-wide DNA methylation analysis reveals novel epigenetic changes in chronic lymphocytic leukemia.Induction of TAp73 by platinum-based compounds to overcome drug resistance in p53 dysfunctional chronic lymphocytic leukemiaNovel targeted agents and the need to refine clinical end points in chronic lymphocytic leukemia.Low dose of lenalidmide and PI3K/mTOR inhibitor trigger synergistic cytoxicity in activated B cell-like subtype of diffuse large B cell lymphoma.Single-agent lenalidomide in the treatment of previously untreated chronic lymphocytic leukemia.Phase II study of lenalidomide and rituximab as salvage therapy for patients with relapsed or refractory chronic lymphocytic leukemia.Lymphocyte cytosolic protein 1 is a chronic lymphocytic leukemia membrane-associated antigen critical to niche homing.Salvage therapy for relapsed chronic lymphocytic leukemia.Aberrantly activated anti-apoptotic signalling mechanisms in chronic lymphocytic leukaemia cells: clues to the identification of novel therapeutic targets.p53 and Notch signaling in chronic lymphocytic leukemia: clues to identifying novel therapeutic strategies.Chronic lymphocytic leukemia: an update on biology and treatment.Treatment of chronic lymphocytic leukemia requires targeting of the protective lymph node environment with novel therapeutic approaches.Treating chronic lymphocytic leukemia with thalidomide and lenalidomide.AdCD40L--crossing the valley of death?
P2860
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P2860
Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B cells through a PI3-kinase-dependent pathway.
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Lenalidomide treatment promote ...... PI3-kinase-dependent pathway.
@ast
Lenalidomide treatment promote ...... PI3-kinase-dependent pathway.
@en
type
label
Lenalidomide treatment promote ...... PI3-kinase-dependent pathway.
@ast
Lenalidomide treatment promote ...... PI3-kinase-dependent pathway.
@en
prefLabel
Lenalidomide treatment promote ...... PI3-kinase-dependent pathway.
@ast
Lenalidomide treatment promote ...... PI3-kinase-dependent pathway.
@en
P2093
P2860
P1433
P1476
Lenalidomide treatment promote ...... PI3-kinase-dependent pathway.
@en
P2093
Amy J Johnson
Amy Lehman
Asha Ramanunni
Chelsey A Raymond
Ching-Shih Chen
Christoph Rader
David Jarjoura
Kristie A Blum
Lan V Pham
Leslie Andritsos
P2860
P304
P356
10.1182/BLOOD-2009-09-242438
P407
P50
P577
2009-11-24T00:00:00Z