Recombinant respiratory syncytial virus (RSV) bearing a set of mutations from cold-passaged RSV is attenuated in chimpanzees - Wikidata - wikimedia - TriplyDB

Recombinant respiratory syncytial virus (RSV) bearing a set of mutations from cold-passaged RSV is attenuated in chimpanzees

Recombinant respiratory syncytial virus (RSV) bearing a set of mutations from cold-passaged RSV is attenuated in chimpanzees

http://www.wikidata.org/entity/Q33782914

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Development of next-generation respiratory virus vaccines through targeted modifications to viral immunomodulatory genes Recent vaccine development for human metapneumovirus Replacement of the ectodomains of the hemagglutinin-neuraminidase and fusion glycoproteins of recombinant parainfluenza virus type 3 (PIV3) with their counterparts from PIV2 yields attenuated PIV2 vaccine candidates Replacement of the F and G proteins of respiratory syncytial virus (RSV) subgroup A with those of subgroup B generates chimeric live attenuated RSV subgroup B vaccine candidates.Recombinant respiratory syncytial virus that does not express the NS1 or M2-2 protein is highly attenuated and immunogenic in chimpanzees Altered growth characteristics of recombinant respiratory syncytial viruses which do not produce NS2 protein.Addition of a missense mutation present in the L gene of respiratory syncytial virus (RSV) cpts530/1030 to RSV vaccine candidate cpts248/404 increases its attenuation and temperature sensitivity.Identification of mutations contributing to the temperature-sensitive, cold-adapted, and attenuation phenotypes of the live-attenuated cold-passage 45 (cp45) human parainfluenza virus 3 candidate vaccine.Recombinant respiratory syncytial virus bearing a deletion of either the NS2 or SH gene is attenuated in chimpanzees.Respiratory syncytial virus G and/or SH protein alters Th1 cytokines, natural killer cells, and neutrophils responding to pulmonary infection in BALB/c mice.Chimeric bovine respiratory syncytial virus with glycoprotein gene substitutions from human respiratory syncytial virus (HRSV): effects on host range and evaluation as a live-attenuated HRSV vaccine Mutations in the 5' trailer region of a respiratory syncytial virus minigenome which limit RNA replication to one step.The major attenuating mutations of the respiratory syncytial virus vaccine candidate cpts530/1009 specify temperature-sensitive defects in transcription and replication and a non-temperature-sensitive alteration in mRNA termination Recombinant respiratory syncytial virus with the G and F genes shifted to the promoter-proximal positions Respiratory syncytial virus infection of human airway epithelial cells is polarized, specific to ciliated cells, and without obvious cytopathology Multiple gene segments control the temperature sensitivity and attenuation phenotypes of ca B/Ann Arbor/1/66.Differential pathogenesis of respiratory syncytial virus clinical isolates in BALB/c mice.Progress in understanding and controlling respiratory syncytial virus: still crazy after all these years Independent structural domains in paramyxovirus polymerase protein.Enhanced Neutralizing Antibody Response Induced by Respiratory Syncytial Virus Prefusion F Protein Expressed by a Vaccine Candidate.Attenuated Human Parainfluenza Virus Type 1 (HPIV1) Expressing the Fusion Glycoprotein of Human Respiratory Syncytial Virus (RSV) as a Bivalent HPIV1/RSV Vaccine.New generation live vaccines against human respiratory syncytial virus designed by reverse genetics.Increased genetic and phenotypic stability of a promising live-attenuated respiratory syncytial virus vaccine candidate by reverse genetics Genetic recombination during coinfection of two mutants of human respiratory syncytial virus.Respiratory syncytial virus modified by deletions of the NS2 gene and amino acid S1313 of the L polymerase protein is a temperature-sensitive, live-attenuated vaccine candidate that is phenotypically stable at physiological temperature.Respiratory syncytial virus: virology, reverse genetics, and pathogenesis of disease.Live-attenuated respiratory syncytial virus vaccines.A single amino acid in the F2 subunit of respiratory syncytial virus fusion protein alters growth and fusogenicity.Packaging and Prefusion Stabilization Separately and Additively Increase the Quantity and Quality of Respiratory Syncytial Virus (RSV)-Neutralizing Antibodies Induced by an RSV Fusion Protein Expressed by a Parainfluenza Virus Vector.The Central Conserved Region (CCR) of Respiratory Syncytial Virus (RSV) G Protein Modulates Host miRNA Expression and Alters the Cellular Response to Infection.Direct whole-genome deep-sequencing of human respiratory syncytial virus A and B from Vietnamese children identifies distinct patterns of inter- and intra-host evolution.Analysis of the noncoding regions of measles virus strains in the Edmonston vaccine lineage.Evolution of the Bunyamwera virus polymerase to accommodate deletions within genomic untranslated region sequences.Attenuated Human Parainfluenza Virus Type 1 Expressing the Respiratory Syncytial Virus (RSV) Fusion (F) Glycoprotein from an Added Gene: Effects of Prefusion Stabilization and Packaging of RSV F.Improved Prefusion Stability, Optimized Codon Usage, and Augmented Virion Packaging Enhance the Immunogenicity of Respiratory Syncytial Virus Fusion Protein in a Vectored-Vaccine Candidate.Live Respiratory Syncytial Virus (RSV) Vaccine Candidate Containing Stabilized Temperature-Sensitivity Mutations Is Highly Attenuated in RSV-Seronegative Infants and Children.

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P2860

Recombinant respiratory syncytial virus (RSV) bearing a set of mutations from cold-passaged RSV is attenuated in chimpanzees

http://www.wikidata.org/entity/Q33782914

description

1998 nî lūn-bûn

@nan

1998 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի մայիսին հրատարակված գիտական հոդված

@hy

1998年の論文

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1998年論文

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1998年論文

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1998年論文

@zh-hk

1998年論文

@zh-mo

1998年論文

@zh-tw

1998年论文

@wuu

name

Recombinant respiratory syncyt ...... V is attenuated in chimpanzees

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Recombinant respiratory syncyt ...... V is attenuated in chimpanzees

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type

label

Recombinant respiratory syncyt ...... V is attenuated in chimpanzees

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Recombinant respiratory syncyt ...... V is attenuated in chimpanzees

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prefLabel

Recombinant respiratory syncyt ...... V is attenuated in chimpanzees

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Recombinant respiratory syncyt ...... V is attenuated in chimpanzees

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P1433

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P2860

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P1433

Journal of Virology

P1476

Recombinant respiratory syncyt ...... V is attenuated in chimpanzees

@en

P2093

B R Murphy

http://www.w3.org/2001/XMLSchema#string

C Y Firestone

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K Juhasz

http://www.w3.org/2001/XMLSchema#string

P L Collins

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S S Whitehead

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P2860

Production of infectious human respiratory syncytial virus from cloned cDNA confirms an essential role for the transcription elongation factor from the 5' proximal open reading frame of the M2 mRNA in gene expression and provides a capability for va

Determinants of attenuation and temperature sensitivity in the type 1 poliovirus Sabin vaccine.

RNA replication by respiratory syncytial virus (RSV) is directed by the N, P, and L proteins; transcription also occurs under these conditions but requires RSV superinfection for efficient synthesis of full-length mRNA.

The temperature-sensitive (ts) phenotype of a cold-passaged (cp) live attenuated respiratory syncytial virus vaccine candidate, designated cpts530, results from a single amino acid substitution in the L protein.

Recombinant respiratory syncytial virus from which the entire SH gene has been deleted grows efficiently in cell culture and exhibits site-specific attenuation in the respiratory tract of the mouse.

Determinants in the 5' noncoding region of poliovirus Sabin 1 RNA that influence the attenuation phenotype.

Genetic basis of attenuation of the Sabin type 3 oral poliovirus vaccine

Four viral genes independently contribute to attenuation of live influenza A/Ann Arbor/6/60 (H2N2) cold-adapted reassortant virus vaccines.

A mutation present in the amino terminus of Sabin 3 poliovirus VP1 protein is attenuating.

Evaluation of two live, cold-passaged, temperature-sensitive respiratory syncytial virus vaccines in chimpanzees and in human adults, infants, and children.

P304

4467-4471

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P31

scholarly article

P433

5

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P478

72

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P577

1998-05-01T00:00:00Z

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P698

9557743

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P932

109683

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