Genome-wide association studies: progress and potential for drug discovery and development. - Wikidata - wikimedia - TriplyDB

Genome-wide association studies: progress and potential for drug discovery and development.

Genome-wide association studies: progress and potential for drug discovery and development.

http://www.wikidata.org/entity/Q33784699

about

Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases Systems genetics for drug target discovery Characterization of schizophrenia adverse drug interactions through a network approach and drug classification The impact of phenocopy on the genetic analysis of complex traits.Determinants of renal disease variability in ADPKD.Genetics of schizophrenia from a clinicial perspective.Bioinformatic analyses identifies novel protein-coding pharmacogenomic markers associated with paclitaxel sensitivity in NCI60 cancer cell lines.Genetic evidence supporting the association of protease and protease inhibitor genes with inflammatory bowel disease: a systematic review Ascertainment biases in SNP chips affect measures of population divergence Can we identify genes for alcohol consumption in samples ascertained for heterogeneous purposes?Next-generation community genetics for low- and middle-income countries A novel generalized ridge regression method for quantitative genetics.Relevant Networks involving the p53 Signalling Pathway in Renal Cell Carcinoma.Large-scale association analysis identifies new risk loci for coronary artery disease Progress toward personalized medicine for glaucoma Three susceptible loci associated with primary open-angle glaucoma identified by genome-wide association study in a Japanese population Sequence variant on 3q28 and urinary bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study.Analytical methods for inferring functional effects of single base pair substitutions in human cancers.New tools for functional genomic analysis.Targeting Anti-Cancer Active Compounds: Affinity-Based Chromatographic Assays.Pharmacogenetics and pharmacogenomics of sexual dysfunction: current status, gaps and potential applications.Cancer proteomics.Family-based association mapping in crop species.Diabetes and its comorbidities--where East meets West.Biological networks and drug discovery--where do we stand?New approaches to establish genetic causality.Compound annotation with real time cellular activity profiles to improve drug discovery.Early Diagnosis of Sepsis: Is an Integrated Omics Approach the Way Forward?Advances in the genetics of schizophrenia: toward a network and pathway view for drug discovery.Fine-mapping of antipsychotic response genome-wide association studies reveals novel regulatory mechanisms.Genetic polymorphisms in the androgen metabolism pathway and risk of prostate cancer in low incidence Malaysian ethnic groups.In silico genotyping of the maize nested association mapping population.Marker selection for genetic case-control association studies.A new statistical screening approach for finding pharmacokinetics-related genes in genome-wide studies.An interactive effect of batch size and composition contributes to discordant results in GWAS with the CHIAMO genotyping algorithm.Efficient estimation of disease odds ratios for follow-up genetic association studies.Batch effects in the BRLMM genotype calling algorithm influence GWAS results for the Affymetrix 500K array.Systems biology-embedded target validation: improving efficacy in drug discovery.Finding melanoma drugs through a probabilistic knowledge graph Genetic Architecture of Soybean Yield and Agronomic Traits

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Genome-wide association studies: progress and potential for drug discovery and development.

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2008 nî lūn-bûn

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2008 թուականի Մարտին հրատարակուած գիտական յօդուած

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2008 թվականի մարտին հրատարակված գիտական հոդված

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2008年論文

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Genome-wide association studie ...... rug discovery and development.

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Nature Reviews Drug Discovery

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Genome-wide association studie ...... rug discovery and development.

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Damian D Gessler

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Ingrid E Lindquist

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Joann Mudge

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William D Beavis

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P2860

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

Multiple Rare Alleles Contribute to Low Plasma Levels of HDL Cholesterol

A comprehensive review of genetic association studies

The allelic architecture of human disease genes: common disease-common variant... or not?

Are rare variants responsible for susceptibility to complex diseases?

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

Searching for genetic determinants in the new millennium

TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta

A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

Identification of four gene variants associated with myocardial infarction.

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221-230

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10.1038/NRD2519

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3

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7

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Stephen F Kingsmore

Stephen F Kingsmore

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genome-wide association study

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2853477

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