Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells.
about
A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer.Oncogenic kit triggers Shp2/Erk1/2 pathway to down-regulate the pro-apoptotic protein Bim and to promote apoptosis resistance in leukemic cellsBim and Mcl-1 exert key roles in regulating JAK2V617F cell survival.Treatment with the Bcl-xL inhibitor ABT-737 in combination with interferon α specifically targets JAK2V617F-positive polycythemia vera hematopoietic progenitor cellsABT-737 induces Bim expression via JNK signaling pathway and its effect on the radiation sensitivity of HeLa cellsTargeting the JAK-STAT pathway in lymphoma: a focus on pacritinib.The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors.The essential role of evasion from cell death in cancer.RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis.JAK2V617F drives Mcl-1 expression and sensitizes hematologic cell lines to dual inhibition of JAK2 and Bcl-xL.A46, a benzothiophene-derived compound, suppresses Jak2-mediated pathologic cell growthIdentification of a Dual Inhibitor of Janus Kinase 2 (JAK2) and p70 Ribosomal S6 Kinase1 (S6K1) Pathways.Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemiaWhacking a mole-cule: clinical activity and mechanisms of resistance to third generation EGFR inhibitors in EGFR mutated lung cancers with EGFR-T790M.Leukemic survival factor SALL4 contributes to defective DNA damage repair.Identification of myeloproliferative neoplasm drug agents via predictive simulation modeling: assessing responsiveness with micro-environment derived cytokines.Combined targeting of JAK2 and Bcl-2/Bcl-xL to cure mutant JAK2-driven malignancies and overcome acquired resistance to JAK2 inhibitors.The role of stem cell factor SALL4 in leukemogenesis.Bcl-2 proteins in development, health, and disease of the hematopoietic system.Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics - recent successes, current challenges and future promise.Epigonal conditioned media from bonnethead shark, Sphyrna tiburo, induces apoptosis in a T-cell leukemia cell line, Jurkat E6-1.Combined antitumor effect of γ-secretase inhibitor and ABT-737 in Notch-expressing non-small cell lung cancer.Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine.Why do BCL-2 inhibitors work and where should we use them in the clinic?Mechanisms for mTORC1 activation and synergistic induction of apoptosis by ruxolitinib and BH3 mimetics or autophagy inhibitors in JAK2-V617F-expressing leukemic cells including newly established PVTL-2.
P2860
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P2860
Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells.
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Apoptosis induced by JAK2 inhi ...... mutant human erythroid cells.
@ast
Apoptosis induced by JAK2 inhi ...... mutant human erythroid cells.
@en
type
label
Apoptosis induced by JAK2 inhi ...... mutant human erythroid cells.
@ast
Apoptosis induced by JAK2 inhi ...... mutant human erythroid cells.
@en
prefLabel
Apoptosis induced by JAK2 inhi ...... mutant human erythroid cells.
@ast
Apoptosis induced by JAK2 inhi ...... mutant human erythroid cells.
@en
P2093
P2860
P1433
P1476
Apoptosis induced by JAK2 inhi ...... 2 mutant human erythroid cells
@en
P2093
Britta Will
Katarina Luptakova
Meritxell Alberich Jordà
Philipp B Staber
Susumu Kobayashi
Takeshi Shimamura
Tanya Siddiqi
Ulrich Steidl
P2860
P304
P356
10.1182/BLOOD-2009-03-209544
P407
P577
2010-02-16T00:00:00Z