CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences
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Engineered Swine Models of CancerGenome Engineering with TALE and CRISPR Systems in NeuroscienceRNA Interference in the Age of CRISPR: Will CRISPR Interfere with RNAi?The therapeutic potential of genome editing for β-thalassemiaNuclease Target Site Selection for Maximizing On-target Activity and Minimizing Off-target Effects in Genome EditingTowards a new era in medicine: therapeutic genome editingHow specific is CRISPR/Cas9 really?Minimizing off-Target Mutagenesis Risks Caused by Programmable NucleasesObesity genetics in mouse and human: back and forth, and back againAdvances in CRISPR-Cas9 genome engineering: lessons learned from RNA interferenceMeasuring and Reducing Off-Target Activities of Programmable Nucleases Including CRISPR-Cas9Genetic screens and functional genomics using CRISPR/Cas9 technologyGenome editing: the road of CRISPR/Cas9 from bench to clinicCRISPR guide RNA design for research applicationsPatterns of CRISPR/Cas9 activity in plants, animals and microbesGenome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screensIn vivo genome editing using Staphylococcus aureus Cas9Cloning-free CRISPRA CRISPR view of development.CRISPRdirect: software for designing CRISPR/Cas guide RNA with reduced off-target sites.GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases.Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy.Optical Control of CRISPR/Cas9 Gene Editing.CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virusHigh-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects.Enhanced specificity and efficiency of the CRISPR/Cas9 system with optimized sgRNA parameters in DrosophilaEfficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target SitesTargeted mutagenesis of aryl hydrocarbon receptor 2a and 2b genes in Atlantic killifish (Fundulus heteroclitus).Targeting non-coding RNAs with the CRISPR/Cas9 system in human cell linesTarget specificity of the CRISPR-Cas9 system.Determining the specificities of TALENs, Cas9, and other genome-editing enzymesLandscape of target:guide homology effects on Cas9-mediated cleavageHigh-throughput functional genomics using CRISPR-Cas9.Efficient fdCas9 Synthetic Endonuclease with Improved Specificity for Precise Genome EngineeringEfficient Genome Editing in Clostridium cellulolyticum via CRISPR-Cas9 Nickase.Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9.Efficient inversions and duplications of mammalian regulatory DNA elements and gene clusters by CRISPR/Cas9.Enhanced Rice Blast Resistance by CRISPR/Cas9-Targeted Mutagenesis of the ERF Transcription Factor Gene OsERF922.Genome Editing with CRISPR-Cas9: Can It Get Any Better?
P2860
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P2860
CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences
description
2014 nî lūn-bûn
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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
CRISPR/Cas9 systems have off-t ...... et DNA and guide RNA sequences
@ast
CRISPR/Cas9 systems have off-t ...... et DNA and guide RNA sequences
@en
type
label
CRISPR/Cas9 systems have off-t ...... et DNA and guide RNA sequences
@ast
CRISPR/Cas9 systems have off-t ...... et DNA and guide RNA sequences
@en
prefLabel
CRISPR/Cas9 systems have off-t ...... et DNA and guide RNA sequences
@ast
CRISPR/Cas9 systems have off-t ...... et DNA and guide RNA sequences
@en
P2093
P2860
P356
P1476
CRISPR/Cas9 systems have off-t ...... et DNA and guide RNA sequences
@en
P2093
Brian M Wile
Frank J Stewart
Harshavardhan Deshmukh
Matthew T Brown
Neha Sarode
Paula M Vertino
Piyush Ranjan
P2860
P304
P356
10.1093/NAR/GKU402
P407
P577
2014-05-16T00:00:00Z