DNA breaks at fragile sites generate oncogenic RET/PTC rearrangements in human thyroid cells.
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Common fragile sites: genomic hotspots of DNA damage and carcinogenesisEvolution of the cancer genomeTopBP1/Dpb11 binds DNA anaphase bridges to prevent genome instability.DNA fragile site breakage as a measure of chemical exposure and predictor of individual susceptibility to form oncogenic rearrangements.Environmental and chemotherapeutic agents induce breakage at genes involved in leukemia-causing gene rearrangements in human hematopoietic stem/progenitor cells.DNA secondary structure at chromosomal fragile sites in human disease.DNA instability at chromosomal fragile sites in cancerLoss of CCDC6 affects cell cycle through impaired intra-S-phase checkpoint controlAre common fragile sites merely structural domains or highly organized "functional" units susceptible to oncogenic stress?DNA topoisomerases participate in fragility of the oncogene RET.Delineating chromosomal breakpoints in radiation-induced papillary thyroid cancer'Chromosomal Rainbows' Detect Oncogenic Rearrangements of Signaling Molecules in Thyroid Tumors.RET/PTC Translocations and Clinico-Pathological Features in Human Papillary Thyroid Carcinoma.Intracellular signal transduction and modification of the tumor microenvironment induced by RET/PTCs in papillary thyroid carcinoma.The role of fragile sites in sporadic papillary thyroid carcinomaExpression and function of nuclear receptor co-activator 4: evidence of a potential role independent of co-activator activity.Role of DNA secondary structures in fragile site breakage along human chromosome 10The cellular etiology of chromosome translocations.Thyroid cancer in 2010: a roadmap for targeted therapies.Tyrosine kinase gene fusions in cancer: translating mechanisms into targeted therapies.Genetics and epigenetics of sporadic thyroid cancer.Central role of RET in thyroid cancer.Thyroid Cancer: Role of RET and Beyond.Molecular characterization of common fragile sites as a strategy to discover cancer susceptibility genes.Interplay between genetic and epigenetic factors governs common fragile site instability in cancer.NADPH oxidases: new actors in thyroid cancer?Genomic rearrangements at the FRA2H common fragile site frequently involve non-homologous recombination events across LTR and L1(LINE) repeats.miRNAs expressed differently in cancer stem cells and cancer cells of human gastric cancer cell line MKN-45.The FRA2C common fragile site maps to the borders of MYCN amplicons in neuroblastoma and is associated with gross chromosomal rearrangements in different cancers.CBFB and MYH11 in inv(16)(p13q22) of acute myeloid leukemia displaying close spatial proximity in interphase nuclei of human hematopoietic stem cells.Platelet-derived growth factors and their receptors in normal and malignant hematopoiesisMolecular profiles of papillary thyroid tumors have been changing in the last decades: how could we explain it?Targeting RET-driven cancers: lessons from evolving preclinical and clinical landscapes.Follicular cell-derived thyroid cancer.Extended RET gene analysis in patients with apparently sporadic medullary thyroid cancer: clinical benefits and cost.
P2860
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P2860
DNA breaks at fragile sites generate oncogenic RET/PTC rearrangements in human thyroid cells.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
DNA breaks at fragile sites ge ...... ements in human thyroid cells.
@ast
DNA breaks at fragile sites ge ...... ements in human thyroid cells.
@en
type
label
DNA breaks at fragile sites ge ...... ements in human thyroid cells.
@ast
DNA breaks at fragile sites ge ...... ements in human thyroid cells.
@en
prefLabel
DNA breaks at fragile sites ge ...... ements in human thyroid cells.
@ast
DNA breaks at fragile sites ge ...... ements in human thyroid cells.
@en
P2093
P2860
P356
P1433
P1476
DNA breaks at fragile sites ge ...... ements in human thyroid cells.
@en
P2093
L W Dillon
S Pramanik
Y E Nikiforov
P2860
P2888
P304
P356
10.1038/ONC.2009.502
P407
P577
2010-01-25T00:00:00Z
P5875
P6179
1013636695