The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemia
about
Glial contributions to neurodegeneration in tauopathies.Increase in α-tubulin modifications in the neuronal processes of hippocampal neurons in both kainic acid-induced epileptic seizure and Alzheimer's disease.The microenvironment in myelodysplastic syndromes: niche-mediated disease initiation and progression.GSK-3β deletion in dentate gyrus excitatory neuron impairs synaptic plasticity and memory.Turning the tide in myelodysplastic/myeloproliferative neoplasms.Stem and progenitor cell alterations in myelodysplastic syndromes.Prognostic models in predicting outcomes in myelodysplastic syndromes after hypomethylating agent failure.Epigenetic dysregulation of hematopoietic stem cells and preleukemic state.Propagation of Tau aggregates.New routes in frontotemporal dementia drug discovery.Diagnosis and classification of hematologic malignancies on the basis of genetics.Cohesin Mutations in Myeloid Malignancies.Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia.Identify latent chromosomal aberrations relevant to myelodysplastic syndromes.The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition.Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effectsDysfunctional diversity of p53 proteins in adult acute myeloid leukemia: projections on diagnostic workup and therapy.CSF tau is associated with impaired cortical plasticity, cognitive decline and astrocyte survival only in APOE4-positive Alzheimer's disease.Amyloid-β and tau complexity - towards improved biomarkers and targeted therapies.A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells.Drug Repurposing for the Treatment of Acute Myeloid Leukemia.A validated antibody panel for the characterization of tau post-translational modifications.Clonal dominance and transplantation dynamics in hematopoietic stem cell compartments.Anti-aggregant tau mutant promotes neurogenesis.Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo.The direct role of 5-lipoxygenase on tau pathology, synaptic integrity and cognition in a mouse model of tauopathy.Overexpression of 5-Lipoxygenase Worsens the Phenotype of a Mouse Model of Tauopathy.RPM-1 regulates axon termination by affecting growth cone collapse and microtubule stability.Development of tau PET Imaging Ligands and their Utility in Preclinical and Clinical Studies.MicroRNAs as New Biomarkers for Diagnosis and Prognosis, and as Potential Therapeutic Targets in Acute Myeloid Leukemia.Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS.EuroTau: towing scientists to tau without tautology.Chilblain lupus and steroid-responsive pancytopenia precede monosomy 7-linked AML as manifestation of rasopathy.Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy.Molecular analysis of myelodysplastic syndrome with isolated deletion of the long arm of chromosome 5 reveals a specific spectrum of molecular mutations with prognostic impact: a study on 123 patients and 27 genes.Clonal evolution in leukemia.Insights from structures of cancer-relevant pre-mRNA splicing factors.Diagnostic and Prognostic Utility of Fluorescence In situ Hybridization (FISH) Analysis in Acute Myeloid Leukemia.Measurement of Residual Disease in Acute Myeloid Leukemia.
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P2860
The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemia
description
2016 nî lūn-bûn
@nan
2016 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
The genetics of myelodysplasti ...... poiesis to secondary leukaemia
@ast
The genetics of myelodysplasti ...... poiesis to secondary leukaemia
@en
type
label
The genetics of myelodysplasti ...... poiesis to secondary leukaemia
@ast
The genetics of myelodysplasti ...... poiesis to secondary leukaemia
@en
prefLabel
The genetics of myelodysplasti ...... poiesis to secondary leukaemia
@ast
The genetics of myelodysplasti ...... poiesis to secondary leukaemia
@en
P2093
P2860
P356
P1476
The genetics of myelodysplasti ...... poiesis to secondary leukaemia
@en
P2093
Adam S Sperling
Benjamin L Ebert
Christopher J Gibson
P2860
P2888
P356
10.1038/NRC.2016.112
P407
P577
2016-11-11T00:00:00Z
P6179
1049787455