Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation
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Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypesHIV Genome-Wide Protein Associations: a Review of 30 Years of ResearchDistinct HIV-1 Escape Patterns Selected by Cytotoxic T Cells with Identical Epitope SpecificityOverlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix.Structure, dynamics, and Hck interaction of full-length HIV-1 Nef.Heterologous Src homology 4 domains support membrane anchoring and biological activity of HIV-1 NefRestoration of wild-type infectivity to human immunodeficiency virus type 1 strains lacking nef by intravirion reverse transcription.Ineffectual targeting of HIV-1 Nef by cytotoxic T lymphocytes in acute infection results in no functional impairment or viremia reduction.Long-term control of HIV-1 in hemophiliacs carrying slow-progressing allele HLA-B*5101Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner.Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.Different effects of Nef-mediated HLA class I down-regulation on human immunodeficiency virus type 1-specific CD8(+) T-cell cytolytic activity and cytokine production.Amino acid residues 88 and 89 in the central hydrophilic region of human immunodeficiency virus type 1 Vif are critical for viral infectivity by enhancing the steady-state expression of Vif.Structural constraints on human immunodeficiency virus type 1 Nef function.Nef-mediated down-regulation of CD4 and HLA class I in HIV-1 subtype C infection: association with disease progression and influence of immune pressure.HIV Nef-mediated major histocompatibility complex class I down-modulation is independent of Arf6 activity.HIV-1 Nef sequence and functional compartmentalization in the gut is not due to differential cytotoxic T lymphocyte selective pressure.At the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosis.Misdirection of membrane trafficking by HIV-1 Vpu and Nef: Keys to viral virulence and persistence.Different Effects of Nonnucleoside Reverse Transcriptase Inhibitor Resistance Mutations on Cytotoxic T Lymphocyte Recognition between HIV-1 Subtype B and Subtype A/E Infections.A noncanonical mu-1A-binding motif in the N terminus of HIV-1 Nef determines its ability to downregulate major histocompatibility complex class I in T lymphocytesEfficient Nef-mediated downmodulation of TCR-CD3 and CD28 is associated with high CD4+ T cell counts in viremic HIV-2 infectionNoise in cellular signaling pathways: causes and effectsDifferential Ability of Primary HIV-1 Nef Isolates To Downregulate HIV-1 Entry Receptors.The vertical transmission of human immunodeficiency virus type 1: molecular and biological properties of the virus.Immune selection in vitro reveals human immunodeficiency virus type 1 Nef sequence motifs important for its immune evasion function in vivo.Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function.Genetic determinants of Nef-mediated CD4 and HLA class I down-regulation differences between HIV-1 subtypes B and C.Human leukocyte antigen (HLA) class I down-regulation by human immunodeficiency virus type 1 negative factor (HIV-1 Nef): what might we learn from natural sequence variants?Cooperative binding of the class I major histocompatibility complex cytoplasmic domain and human immunodeficiency virus type 1 Nef to the endosomal AP-1 complex via its mu subunitSelective downregulation of rhesus macaque and sooty mangabey major histocompatibility complex class I molecules by Nef alleles of simian immunodeficiency virus and human immunodeficiency virus type 2.Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways.HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice.Functional characterization of the human immunodeficiency virus type 1 Nef acidic domain.Mechanisms of HIV-1 Nef function and intracellular signaling.HIV-1 Control by NK Cells via Reduced Interaction between KIR2DL2 and HLA-C∗12:02/C∗14:03Human immunodeficiency virus type 1 Nef domains required for disruption of major histocompatibility complex class I trafficking are also necessary for coprecipitation of Nef with HLA-A2.HIV immune evasion disruption of antigen presentation by the HIV Nef protein.The Nef-infectivity enigma: mechanisms of enhanced lentiviral infection.Down-modulation of CD8αβ is a fundamental activity of primate lentiviral Nef proteins.
P2860
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P2860
Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation
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name
Nef-induced major histocompati ...... ivity, and CD4 down-regulation
@ast
Nef-induced major histocompati ...... ivity, and CD4 down-regulation
@en
type
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Nef-induced major histocompati ...... ivity, and CD4 down-regulation
@ast
Nef-induced major histocompati ...... ivity, and CD4 down-regulation
@en
prefLabel
Nef-induced major histocompati ...... ivity, and CD4 down-regulation
@ast
Nef-induced major histocompati ...... ivity, and CD4 down-regulation
@en
P2093
P2860
P1433
P1476
Nef-induced major histocompati ...... ivity, and CD4 down-regulation
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P2093
P2860
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P356
10.1128/JVI.74.6.2907-2912.2000
P577
2000-03-01T00:00:00Z