Cancer risk in ATM heterozygotes: a model of phenotypic and mechanistic differences between missense and truncating mutations.
about
Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibilityAtm heterozygous deficiency enhances development of mammary carcinomas in p53 heterozygous knockout mice.Workshop on The Epidemiology of the ATM Gene: Impact on Breast Cancer Risk and Treatment, Present Status and Future Focus, Lillehammer, Norway, 29 June 2002.Phosphoinositide 3-kinase signalling in breast cancer: how big a role might it play?Frequency of the ATM IVS10-6T-->G variant in Australian multiple-case breast cancer familiesFunctional and computational assessment of missense variants in the ataxia-telangiectasia mutated (ATM) gene: mutations with increased cancer risk.Cancer risk and the ATM gene: a continuing debate.Hemizygosity for Atm and Brca1 influence the balance between cell transformation and apoptosis.Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer.Missense variants in ATM in 26,101 breast cancer cases and 29,842 controls.Haplotypes at ATM identify coding-sequence variation and indicate a region of extensive linkage disequilibrium.Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenanceMetastasis of neuroendocrine tumors are characterized by increased cell proliferation and reduced expression of the ATM geneATM gene and lymphoid malignancies.Ataxia telangiectasia gene mutations in leukaemia and lymphoma.Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes.Genetic determinants at the interface of cancer and neurodegenerative disease.Cancer risks and mortality in heterozygous ATM mutation carriers.ATM, a central controller of cellular responses to DNA damage.ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles.ATM and breast cancer susceptibility.ATM gene mutations in sporadic breast cancer patients from Brazil.The DNA damage checkpoint and human cancer.Rare variants in the ATM gene and risk of breast cancerThe ATM missense mutation p.Ser49Cys (c.146C>G) and the risk of breast cancer.Identification of women with an increased risk of developing radiation-induced breast cancer: a case only study.Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrenceBreast cancer susceptibility and the DNA damage response.The spectrum of ATM missense variants and their contribution to contralateral breast cancerSystems biological and mechanistic modelling of radiation-induced cancer.ATM haplotypes and breast cancer risk in Jewish high-risk women.Screening breast cancer patients for Norwegian ATM mutationsCellular responses to ionising radiation of AT heterozygotes: differences between missense and truncating mutation carriers.ATM gene mutations result in both recessive and dominant expression phenotypes of genes and microRNAs.Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitorsGenetic variations in DNA repair genes, radiosensitivity to cancer and susceptibility to acute tissue reactions in radiotherapy-treated cancer patients.Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer.Rare, evolutionarily unlikely missense substitutions in ATM confer increased risk of breast cancerAberrant methylation of the ATM promoter correlates with increased radiosensitivity in a human colorectal tumor cell line.TCL-1, MTCP-1 and TML-1 gene expression profile in non-leukemic clonal proliferations associated with ataxia-telangiectasia.
P2860
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P2860
Cancer risk in ATM heterozygotes: a model of phenotypic and mechanistic differences between missense and truncating mutations.
description
1999 nî lūn-bûn
@nan
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Cancer risk in ATM heterozygot ...... ense and truncating mutations.
@ast
Cancer risk in ATM heterozygot ...... ense and truncating mutations.
@en
type
label
Cancer risk in ATM heterozygot ...... ense and truncating mutations.
@ast
Cancer risk in ATM heterozygot ...... ense and truncating mutations.
@en
prefLabel
Cancer risk in ATM heterozygot ...... ense and truncating mutations.
@ast
Cancer risk in ATM heterozygot ...... ense and truncating mutations.
@en
P356
P1476
Cancer risk in ATM heterozygot ...... ense and truncating mutations.
@en
P2093
P304
P356
10.1006/MGME.1999.2942
P577
1999-12-01T00:00:00Z