Engaging in paced mating, but neither exploratory, anti-anxiety, nor social behavior, increases 5alpha-reduced progestin concentrations in midbrain, hippocampus, striatum, and cortex
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Neurosteroids' effects and mechanisms for social, cognitive, emotional, and physical functionsAlteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolaseEstrogen action: a historic perspective on the implications of considering alternative approaches.Estrogen is necessary for 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) infusion to the ventral tegmental area to facilitate social and sexual, but neither exploratory nor affective behavior of ovariectomized rats.Conjugated equine estrogen, with medroxyprogesterone acetate, enhances formation of 5alpha-reduced progestogens and reduces anxiety-like behavior of middle-aged rats.The testosterone metabolite 3α-diol enhances female rat sexual motivation when infused in the nucleus accumbens shellDistribution of mRNAs encoding classical progestin receptor, progesterone membrane components 1 and 2, serpine mRNA binding protein 1, and progestin and ADIPOQ receptor family members 7 and 8 in rat forebrainII. Cognitive performance of middle-aged female rats is influenced by capacity to metabolize progesterone in the prefrontal cortex and hippocampus.Juvenile offspring of rats exposed to restraint stress in late gestation have impaired cognitive performance and dysregulated progestogen formation.I. Levels of 5α-reduced progesterone metabolite in the midbrain account for variability in reproductive behavior of middle-aged female ratsInhibition of 5α-reductase activity in late pregnancy decreases gestational length and fecundity and impairs object memory and central progestogen milieu of juvenile rat offspringNovel substrates for, and sources of, progestogens for reproduction.Effects and Mechanisms of 3α,5α,-THP on Emotion, Motivation, and Reward Functions Involving Pregnane Xenobiotic Receptor.Progesterone can enhance consolidation and/or performance in spatial, object and working memory tasks in Long-Evans rats.Immune stress in late pregnant rats decreases length of gestation and fecundity, and alters later cognitive and affective behaviour of surviving pre-adolescent offspring.Gestational exposure to variable stressors produces decrements in cognitive and neural development of juvenile male and female rats.Gestational or acute restraint in adulthood reduces levels of 5α-reduced testosterone metabolites in the hippocampus and produces behavioral inhibition of adult male ratsLow doses of cocaine decrease, and high doses increase, anxiety-like behavior and brain progestogen levels among intact rats.Effects of neurosteroid actions at N-methyl-D-aspartate and GABA A receptors in the midbrain ventral tegmental area for anxiety-like and mating behavior of female rats.Anti-anxiety, cognitive, and steroid biosynthetic effects of an isoflavone-based dietary supplement are gonad and sex-dependent in ratsMembrane actions of progestins at dopamine type 1-like and GABAA receptors involve downstream signal transduction pathways.Estrous cycle, pregnancy, and parity enhance performance of rats in object recognition or object placement tasks.Exploratory, anti-anxiety, social, and sexual behaviors of rats in behavioral estrus is attenuated with inhibition of 3alpha,5alpha-THP formation in the midbrain ventral tegmental area.Infusions of 3alpha,5alpha-THP to the VTA enhance exploratory, anti-anxiety, social, and sexual behavior and increase levels of 3alpha,5alpha-THP in midbrain, hippocampus, diencephalon, and cortex of female rats.Activity of protein kinase C is important for 3alpha,5alpha-THP's actions at dopamine type 1-like and/or GABAA receptors in the ventral tegmental area for lordosis of rats.Motivated behaviors and levels of 3α,5α-THP in the midbrain are attenuated by knocking down expression of pregnane xenobiotic receptor in the midbrain ventral tegmental area of proestrous rats.Infusions of bicuculline to the ventral tegmental area attenuates sexual, exploratory, and anti-anxiety behavior of proestrous rats.Increasing 3alpha,5alpha-THP following inhibition of neurosteroid biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally receptive rats.Pregnane xenobiotic receptors and membrane progestin receptors: role in neurosteroid-mediated motivated behavioursNovel receptor targets for production and action of allopregnanolone in the central nervous system: a focus on pregnane xenobiotic receptorProgestogens influence cognitive processes in aging.Ginsenoside Rg1 protects against neuronal degeneration induced by chronic dexamethasone treatment by inhibiting NLRP-1 inflammasomes in mice.In the ventral tegmental area, the membrane-mediated actions of progestins for lordosis of hormone-primed hamsters involve phospholipase C and protein kinase C.
P2860
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P2860
Engaging in paced mating, but neither exploratory, anti-anxiety, nor social behavior, increases 5alpha-reduced progestin concentrations in midbrain, hippocampus, striatum, and cortex
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2007 nî lūn-bûn
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2007年の論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年论文
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name
Engaging in paced mating, but ...... pocampus, striatum, and cortex
@ast
Engaging in paced mating, but ...... pocampus, striatum, and cortex
@en
type
label
Engaging in paced mating, but ...... pocampus, striatum, and cortex
@ast
Engaging in paced mating, but ...... pocampus, striatum, and cortex
@en
prefLabel
Engaging in paced mating, but ...... pocampus, striatum, and cortex
@ast
Engaging in paced mating, but ...... pocampus, striatum, and cortex
@en
P2093
P2860
P356
P1433
P1476
Engaging in paced mating, but ...... pocampus, striatum, and cortex
@en
P2093
Cheryl A Frye
Jason J Paris
Madeline E Rhodes
P2860
P304
P356
10.1530/REP.1.01208
P577
2007-03-01T00:00:00Z