Increasing 3alpha,5alpha-THP following inhibition of neurosteroid biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally receptive rats.
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In a mouse model relevant for post-traumatic stress disorder, selective brain steroidogenic stimulants (SBSS) improve behavioral deficits by normalizing allopregnanolone biosynthesis.Role of neurosteroids in the anticonvulsant activity of midazolamNeurosteroids reduce social isolation-induced behavioral deficits: a proposed link with neurosteroid-mediated upregulation of BDNF expression.I. Levels of 5α-reduced progesterone metabolite in the midbrain account for variability in reproductive behavior of middle-aged female ratsPostnatal administration of allopregnanolone modifies glutamate release but not BDNF content in striatum samples of rats prenatally exposed to ethanolMinireview: translocator protein (TSPO) and steroidogenesis: a reappraisal.Novel substrates for, and sources of, progestogens for reproduction.Up-regulation of neurosteroid biosynthesis as a pharmacological strategy to improve behavioural deficits in a putative mouse model of post-traumatic stress disorderEffects and Mechanisms of 3α,5α,-THP on Emotion, Motivation, and Reward Functions Involving Pregnane Xenobiotic Receptor.Progesterone-facilitated lordosis of estradiol-primed mice is attenuated by knocking down expression of membrane progestin receptors in the midbrain.Membrane progestin receptors in the midbrain ventral tegmental area are required for progesterone-facilitated lordosis of ratsProgesterone turnover to its 5α-reduced metabolites in the ventral tegmental area of the midbrain is essential for initiating social and affective behavior and progesterone metabolism in female rats.Low doses of cocaine decrease, and high doses increase, anxiety-like behavior and brain progestogen levels among intact rats.Effects of neurosteroid actions at N-methyl-D-aspartate and GABA A receptors in the midbrain ventral tegmental area for anxiety-like and mating behavior of female rats.Motivated behaviors and levels of 3α,5α-THP in the midbrain are attenuated by knocking down expression of pregnane xenobiotic receptor in the midbrain ventral tegmental area of proestrous rats.Infusions of bicuculline to the ventral tegmental area attenuates sexual, exploratory, and anti-anxiety behavior of proestrous rats.Brain levels of prostaglandins, endocannabinoids, and related lipids are affected by mating strategies.Puberty, steroids and GABA(A) receptor plasticity.The pregnane xenobiotic receptor, a prominent liver factor, has actions in the midbrain for neurosteroid synthesis and behavioral/neural plasticity of female rats.Allopregnanolone and suppressed hypothalamo-pituitary-adrenal axis stress responses in late pregnancy in the rat.Reconsidering GHB: orphan drug or new model antidepressant?
P2860
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P2860
Increasing 3alpha,5alpha-THP following inhibition of neurosteroid biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally receptive rats.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 25 September 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Increasing 3alpha,5alpha-THP f ...... r of naturally receptive rats.
@en
Increasing 3alpha,5alpha-THP f ...... r of naturally receptive rats.
@nl
type
label
Increasing 3alpha,5alpha-THP f ...... r of naturally receptive rats.
@en
Increasing 3alpha,5alpha-THP f ...... r of naturally receptive rats.
@nl
prefLabel
Increasing 3alpha,5alpha-THP f ...... r of naturally receptive rats.
@en
Increasing 3alpha,5alpha-THP f ...... r of naturally receptive rats.
@nl
P2093
P2860
P356
P1433
P1476
Increasing 3alpha,5alpha-THP f ...... r of naturally receptive rats.
@en
P2093
Cheryl A Frye
Jason J Paris
Madeline E Rhodes
P2860
P304
P356
10.1530/REP-08-0250
P577
2008-09-25T00:00:00Z