about
Retroviral intasome assembly and inhibition of DNA strand transferG-Quadruplex Forming Oligonucleotides as Anti-HIV AgentsMolecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)A Crystal Structure of the Catalytic Core Domain of an Avian Sarcoma and Leukemia Virus Integrase Suggests an Alternate Dimeric AssemblyActivities, Crystal Structures, and Molecular Dynamics of Dihydro-1 H -isoindole Derivatives, Inhibitors of HIV-1 Integrase3′-Processing and strand transfer catalysed by retroviral integrasein crystalloUse of Aptamers as Diagnostics Tools and Antiviral Agents for Human VirusesStructure-analysis of the HIV-1 integrase Y143C/R raltegravir resistance mutation in association with the secondary mutation T97AUnprocessed viral DNA could be the primary target of the HIV-1 integrase inhibitor raltegravirBiochemical and pharmacological analyses of HIV-1 integrase flexible loop mutants resistant to raltegravirResistance to integrase inhibitors.Bicyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.In vitro evolution of an HIV integrase binding protein from a library of C-terminal domain γS-crystallin variants.4-amino-1-hydroxy-2-oxo-1,8-naphthyridine-containing compounds having high potency against raltegravir-resistant integrase mutants of HIV-1G-quadruplexes in viruses: function and potential therapeutic applications.Recombinant rabbit single-chain antibodies bind to the catalytic and C-terminal domains of HIV-1 integrase protein and strongly inhibit HIV-1 replication3-Hydroxypyrimidine-2,4-diones as an inhibitor scaffold of HIV integraseComputational investigation of the anti-HIV activity of Chinese medicinal formula Three-Huang Powder.Development of tricyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.Potential elucidation of a novel CTL epitope in HIV-1 protease by the protease inhibitor resistance mutation L90M.MK-0536 inhibits HIV-1 integrases resistant to raltegravirMolecular dynamics approaches estimate the binding energy of HIV-1 integrase inhibitors and correlate with in vitro activity.Probing chelation motifs in HIV integrase inhibitorsComputer tools in the discovery of HIV-1 integrase inhibitorsAuthentic HIV-1 integrase inhibitors.6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors.3-Hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides Potently Inhibit HIV-1 Integrase and RNase H.Selectivity for strand-transfer over 3'-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme-DNA interactions in the active site.Effect of Cabotegravir on Cardiac Repolarization in Healthy Subjects.Bicyclic 1-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-containing HIV-1 integrase inhibitors having high antiviral potency against cells harboring raltegravir-resistant integrase mutants.Novel integrase inhibitors for HIV.The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional InsightsInterfacial inhibitors: targeting macromolecular complexes.Next-generation integrase inhibitors : where to after raltegravir?Molecular dynamics of HIV1-integrase in complex with 93del - a structural perspective on the mechanism of inhibition.HIV-1 integrase inhibitor T30177 forms a stacked dimeric G-quadruplex structure containing bulges.Nitrogen-containing polyhydroxylated aromatics as HIV-1 integrase inhibitors: synthesis, structure-activity relationship analysis, and biological activity.Structure-Activity Relationship Studies of HIV-1 Integrase Oligonucleotide Inhibitors.Identification of spirocyclic or phosphate substituted quinolizine derivatives as novel HIV-1 integrase inhibitors: a patent evaluation of WO2016094197A1, WO2016094198A1 and WO2016154527A1.
P2860
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P2860
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
HIV-1 IN inhibitors: 2010 update and perspectives
@ast
HIV-1 IN inhibitors: 2010 update and perspectives
@en
type
label
HIV-1 IN inhibitors: 2010 update and perspectives
@ast
HIV-1 IN inhibitors: 2010 update and perspectives
@en
prefLabel
HIV-1 IN inhibitors: 2010 update and perspectives
@ast
HIV-1 IN inhibitors: 2010 update and perspectives
@en
P2093
P2860
P1476
HIV-1 IN inhibitors: 2010 update and perspectives
@en
P2093
Christophe Marchand
Kasthuraiah Maddali
Mathieu Métifiot
P2860
P304
P356
10.2174/156802609789630910
P50
P577
2009-01-01T00:00:00Z