STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice - Wikidata - wikimedia - TriplyDB

STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice

STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice

http://www.wikidata.org/entity/Q33815644

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STRAD pseudokinases regulate axogenesis and LKB1 stability Molecular Pathways Underlying Projection Neuron Production and Migration during Cerebral Cortical Development Amino acids and mTORC1: from lysosomes to disease Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target Pathogenesis and new candidate treatments for infantile spasms and early life epileptic encephalopathies: A view from preclinical studies mTOR inhibition suppresses established epilepsy in a mouse model of cortical dysplasia.Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement.A genome-wide siRNA screen in mammalian cells for regulators of S6 phosphorylation Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice Rapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorder A homozygous missense mutation in HERC2 associated with global developmental delay and autism spectrum disorder.mTOR signaling in epilepsy: insights from malformations of cortical development Recessive nephrocerebellar syndrome on the Galloway-Mowat syndrome spectrum is caused by homozygous protein-truncating mutations of WDR73.Multiple roles for mammalian target of rapamycin signaling in both glutamatergic and GABAergic synaptic transmission Rheb activation in subventricular zone progenitors leads to heterotopia, ectopic neuronal differentiation, and rapamycin-sensitive olfactory micronodules and dendrite hypertrophy of newborn neurons.Formation of chimeric genes by copy-number variation as a mutational mechanism in schizophrenia.Normalizing translation through 4E-BP prevents mTOR-driven cortical mislamination and ameliorates aberrant neuron integration.Dysregulation of mTOR activity through LKB1 inactivation.Acute inactivation of the serine-threonine kinase Stk25 disrupts neuronal migration.Mammalian target of rapamycin (mTOR) inhibition: potential for antiseizure, antiepileptogenic, and epileptostatic therapy.A critical review of mTOR inhibitors and epilepsy: from basic science to clinical trials.Mammalian target of rapamycin (mTOR) pathways in neurological diseases.Fetal brain mTOR signaling activation in tuberous sclerosis complex.Mechanisms of epileptogenesis in pediatric epileptic syndromes: Rasmussen encephalitis, infantile spasms, and febrile infection-related epilepsy syndrome (FIRES).Mammalian target of rapamycin (mTOR) activation in focal cortical dysplasia and related focal cortical malformations mTOR inhibitors as a new therapeutic option for epilepsy.The relationship between genes affecting the development of epilepsy and approaches to epilepsy therapy.Molecules and mechanisms that regulate multipolar migration in the intermediate zone.mTOR inhibition in epilepsy: rationale and clinical perspectives.Genetic animal models of malformations of cortical development and epilepsy.mTOR in Brain Physiology and Pathologies.Inflammation in Epileptic Encephalopathies.Neuroinflammation in epileptogenesis: Insights and translational perspectives from new models of epilepsy.mTOR Inhibitors in Children: Current Indications and Future Directions in Neurology.Caveat mTOR: aberrant signaling disrupts corticogenesis.LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.Rational therapy from bench to bedside for a rare epilepsy Sending Mixed Signals: The Expanding Role of Molecular Cascade Mutations in Malformations of Cortical Development and Epilepsy.Hydrogen sulfide mitigates hyperglycemic remodeling via liver kinase B1-adenosine monophosphate-activated protein kinase signaling.Re-positioning of somatic Golgi apparatus is essential for the dendritic establishment of adult-born hippocampal neurons.

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P2860

STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice

http://www.wikidata.org/entity/Q33815644

description

2010 nî lūn-bûn

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2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի ապրիլին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

STRADalpha deficiency results ...... ticogenesis in humans and mice

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STRADalpha deficiency results ...... ticogenesis in humans and mice

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type

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STRADalpha deficiency results ...... ticogenesis in humans and mice

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STRADalpha deficiency results ...... ticogenesis in humans and mice

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prefLabel

STRADalpha deficiency results ...... ticogenesis in humans and mice

@ast

STRADalpha deficiency results ...... ticogenesis in humans and mice

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Journal of Clinical Investigation

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STRADalpha deficiency results ...... ticogenesis in humans and mice

@en

P2093

Gregory G Heuer

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Jason Yoon

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Kevin Strauss

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Ksenia A Orlova

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Marianna Baybis

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Peter B Crino

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Robert S Fenning

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Victoria Tsai

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Whitney E Parker

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P2860

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

Protean PTEN: form and function

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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10.1172/JCI41592

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5

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20424326

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2860905

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