Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes - Wikidata - wikimedia - TriplyDB

Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes

Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes

http://www.wikidata.org/entity/Q33816985

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Topoisomerase I in Human Disease Pathogenesis and Treatments Ataxia telangiectasia: a review XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia.Neuroprotection and repair of 3'-blocking DNA ends by glaikit (gkt) encoding Drosophila tyrosyl-DNA phosphodiesterase 1 (TDP1).Topoisomerase 1 inhibition reversibly impairs synaptic function.APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination.DICER-dependent biogenesis of let-7 miRNAs affects human cell response to DNA damage via targeting p21/p27.Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms.Gene length matters in neurons DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions.Isoeugenol is a selective potentiator of camptothecin cytotoxicity in vertebrate cells lacking TDP1 Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis.DNA repair abnormalities leading to ataxia: shared neurological phenotypes and risk factors.Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability Topoisomerase-mediated chromosomal break repair: an emerging player in many games.Personalised Medicine: Genome Maintenance Lessons Learned from Studies in Yeast as a Model Organism.Genome Organization Drives Chromosome Fragility.Topoisomerases and the regulation of neural function.ATM is required for SOD2 expression and homeostasis within the mammary gland.C9orf72 expansion disrupts ATM-mediated chromosomal break repair.Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability.Chromosome territory relocation during DNA repair requires nuclear myosin 1 recruitment to chromatin mediated by ϒ-H2AX signaling.The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks Length-dependent gene misexpression is associated with Alzheimer's disease progression DNA single-strand break-induced DNA damage response causes heart failure.Genome integrity and disease prevention in the nervous system.Role of Estrogen and Other Sex Hormones in Brain Aging. Neuroprotection and DNA Repair.LncRNA lnc-RI regulates homologous recombination repair of DNA double-strand breaks by stabilizing RAD51 mRNA as a competitive endogenous RNA.Structural alteration of DNA induced by viral protein R of HIV-1 triggers the DNA damage response.DNA damage in the oligodendrocyte lineage and its role in brain aging.ATM-dependent pathways of chromatin remodelling and oxidative DNA damage responses.Perturbed autophagy and DNA repair converge to promote neurodegeneration in amyotrophic lateral sclerosis and dementia.PRMT5-mediated arginine methylation of TDP1 for the repair of topoisomerase I covalent complexes.A mechanism for semaphorin-induced apoptosis: DNA damage of endothelial and myogenic cells in primary cultures from skeletal muscle.UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis.DNA protein crosslink proteolysis repair: From yeast to premature ageing and cancer in humans PARP-1-dependent RND1 transcription induced by topoisomerase I cleavage complexes confers cellular resistance to camptothecin

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Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes

http://www.wikidata.org/entity/Q33816985

description

2014 nî lūn-bûn

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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2014 թվականի մայիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Aberrant topoisomerase-1 DNA l ...... e genome instability syndromes

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Aberrant topoisomerase-1 DNA l ...... e genome instability syndromes

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type

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Aberrant topoisomerase-1 DNA l ...... e genome instability syndromes

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Aberrant topoisomerase-1 DNA l ...... e genome instability syndromes

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Aberrant topoisomerase-1 DNA l ...... e genome instability syndromes

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Nature Neuroscience

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Aberrant topoisomerase-1 DNA l ...... e genome instability syndromes

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Helen R Russell

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Jingfeng Zhao

http://www.w3.org/2001/XMLSchema#string

Karin C Nitiss

http://www.w3.org/2001/XMLSchema#string

Peter J McKinnon

http://www.w3.org/2001/XMLSchema#string

Susanna M Downing

http://www.w3.org/2001/XMLSchema#string

Yang Li

http://www.w3.org/2001/XMLSchema#string

Youngsoo Lee

http://www.w3.org/2001/XMLSchema#string

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Cellular roles of dna topoisomerases: a molecular perspective

The role of double-strand break repair — insights from human genetics

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates

The DNA-damage response in human biology and disease

Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK

Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks

SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage

Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene

Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy

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813-821

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10.1038/NN.3715

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6

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262051835

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24793032

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neurodegeneration

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4074009

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