Persistent CCR5 utilization and enhanced macrophage tropism by primary blood human immunodeficiency virus type 1 isolates from advanced stages of disease and comparison to tissue-derived isolates
about
TAK-652 inhibits CCR5-mediated human immunodeficiency virus type 1 infection in vitro and has favorable pharmacokinetics in humansHIV-1 envelope-receptor interactions required for macrophage infection and implications for current HIV-1 cure strategiesPotent, broad-spectrum inhibition of human immunodeficiency virus type 1 by the CCR5 monoclonal antibody PRO 140Selective transmission of R5 HIV-1 over X4 HIV-1 at the dendritic cell-T cell infectious synapse is determined by the T cell activation state.Proteomic analysis of HIV-infected macrophagesUse of inhibitors to evaluate coreceptor usage by simian and simian/human immunodeficiency viruses and human immunodeficiency virus type 2 in primary cells.Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity.Identification of shared populations of human immunodeficiency virus type 1 infecting microglia and tissue macrophages outside the central nervous system.Adoption of an "open" envelope conformation facilitating CD4 binding and structural remodeling precedes coreceptor switch in R5 SHIV-infected macaques.The contribution of peroxynitrite generation in HIV replication in human primary macrophages.Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS.Variation in the biological properties of HIV-1 R5 envelopes: implications of envelope structure, transmission and pathogenesis.Contribution of proteoglycans to human immunodeficiency virus type 1 brain invasion.A human immunodeficiency virus type 1 isolate from an infected person homozygous for CCR5Delta32 exhibits dual tropism by infecting macrophages and MT2 cells via CXCR4.Increased CCR5 affinity and reduced CCR5/CD4 dependence of a neurovirulent primary human immunodeficiency virus type 1 isolate.A machine learning approach for identifying amino acid signatures in the HIV env gene predictive of dementia.Distinct HIV-1 entry phenotypes are associated with transmission, subtype specificity, and resistance to broadly neutralizing antibodies.Non-macrophage-tropic human immunodeficiency virus type 1 R5 envelopes predominate in blood, lymph nodes, and semen: implications for transmission and pathogenesis.A conserved determinant in the V1 loop of HIV-1 modulates the V3 loop to prime low CD4 use and macrophage infection.Inhibition of dual/mixed tropic HIV-1 isolates by CCR5-inhibitors in primary lymphocytes and macrophages.An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes.The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementia.HIV-1 escape from the CCR5 antagonist maraviroc associated with an altered and less-efficient mechanism of gp120-CCR5 engagement that attenuates macrophage tropismAnti-nerve growth factor Ab abrogates macrophage-mediated HIV-1 infection and depletion of CD4+ T lymphocytes in hu-SCID miceHIV-1 target cells in the CNS.HIV-1 non-macrophage-tropic R5 envelope glycoproteins are not more tropic for entry into primary CD4+ T-cells than envelopes highly adapted for macrophages.Alternative coreceptor requirements for efficient CCR5- and CXCR4-mediated HIV-1 entry into macrophages.HIV reservoirs in vivo and new strategies for possible eradication of HIV from the reservoir sites.Viral determinants of HIV-1 macrophage tropism.Phenotype and envelope gene diversity of nef-deleted HIV-1 isolated from long-term survivors infected from a single source.Independent evolution of macrophage-tropism and increased charge between HIV-1 R5 envelopes present in brain and immune tissue.HIV's double strike at the brain: neuronal toxicity and compromised neurogenesis.Phenotypic Correlates of HIV-1 Macrophage Tropism.CSF-induced and HIV-1-mediated distinct regulation of Hck and C/EBPbeta represent a heterogeneous susceptibility of monocyte-derived macrophages to M-tropic HIV-1 infection.Affinofile profiling: how efficiency of CD4/CCR5 usage impacts the biological and pathogenic phenotype of HIVMacrophage-tropic HIV-1 variants from brain demonstrate alterations in the way gp120 engages both CD4 and CCR5Identification of interdependent variables that influence coreceptor switch in R5 SHIV(SF162P3N)-infected macaques.Retinoid-dependent restriction of human immunodeficiency virus type 1 replication in monocytes/macrophagesHIV-1 pathogenesis: the virus.The HIV-1 env protein: a coat of many colors.
P2860
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P2860
Persistent CCR5 utilization and enhanced macrophage tropism by primary blood human immunodeficiency virus type 1 isolates from advanced stages of disease and comparison to tissue-derived isolates
description
1999 nî lūn-bûn
@nan
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Persistent CCR5 utilization an ...... son to tissue-derived isolates
@ast
Persistent CCR5 utilization an ...... son to tissue-derived isolates
@en
type
label
Persistent CCR5 utilization an ...... son to tissue-derived isolates
@ast
Persistent CCR5 utilization an ...... son to tissue-derived isolates
@en
prefLabel
Persistent CCR5 utilization an ...... son to tissue-derived isolates
@ast
Persistent CCR5 utilization an ...... son to tissue-derived isolates
@en
P2093
P2860
P1433
P1476
Persistent CCR5 utilization an ...... son to tissue-derived isolates
@en
P2093
A Cunningham
P2860
P304
P577
1999-12-01T00:00:00Z