Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization
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Cholesterol esterification by ACAT2 is essential for efficient intestinal cholesterol absorption: evidence from thoracic lymph duct cannulationTG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2.Acute sterol o-acyltransferase 2 (SOAT2) knockdown rapidly mobilizes hepatic cholesterol for fecal excretion.An approach to identify SNPs in the gene encoding acetyl-CoA acetyltransferase-2 (ACAT-2) and their proposed role in metabolic processes in pig.Multiple mechanisms limit the accumulation of unesterified cholesterol in the small intestine of mice deficient in both ACAT2 and ABCA1.Cholesterol esters (CE) derived from hepatic sterol O-acyltransferase 2 (SOAT2) are associated with more atherosclerosis than CE from intestinal SOAT2Deletion of sterol O-acyltransferase 2 (SOAT2) function in mice deficient in lysosomal acid lipase (LAL) dramatically reduces esterified cholesterol sequestration in the small intestine and liver.The regulation of alfalfa saponin extract on key genes involved in hepatic cholesterol metabolism in hyperlipidemic ratsHepatic ACAT2 knock down increases ABCA1 and modifies HDL metabolism in miceTissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood.Hepatic overexpression of methionine sulfoxide reductase A reduces atherosclerosis in apolipoprotein E-deficient mice.PRD125, a potent and selective inhibitor of sterol O-acyltransferase 2 markedly reduces hepatic cholesteryl ester accumulation and improves liver function in lysosomal acid lipase-deficient miceIntestine-specific MTP and global ACAT2 deficiency lowers acute cholesterol absorption with chylomicrons and HDLsSex-Specific Differences in Hepatic Fat Oxidation and Synthesis May Explain the Higher Propensity for NAFLD in Men.Influence of the Alcohol Present in a Phytotherapic Tincture on Male Rat Lipid Profiles and Renal Function.Carvacrol Protects against Hepatic Steatosis in Mice Fed a High-Fat Diet by Enhancing SIRT1-AMPK Signaling.Apigenin Ameliorates Dyslipidemia, Hepatic Steatosis and Insulin Resistance by Modulating Metabolic and Transcriptional Profiles in the Liver of High-Fat Diet-Induced Obese Mice.The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis.Gut-liver interaction in triglyceride-rich lipoprotein metabolism.Isoform-specific inhibitors of ACATs: recent advances and promising developments.Acyltransferase inhibitors: a patent review (2010-present).Chemical Genetic Approaches for the Investigation of Neutral Lipid Metabolism.Reduction of VLDL secretion decreases cholesterol excretion in niemann-pick C1-like 1 hepatic transgenic mice.Shunts, channels and lipoprotein endosomal traffic: a new model of cholesterol homeostasis in the hepatocyte.Nonalcoholic Fatty liver disease: focus on lipoprotein and lipid deregulation.Using self-organizing map (SOM) and support vector machine (SVM) for classification of selectivity of ACAT inhibitors.Adipose tissues of MPC1 mice display altered lipid metabolism-related enzyme expression levels
P2860
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P2860
Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Inhibition of acyl-coenzyme A: ...... atic triglyceride mobilization
@ast
Inhibition of acyl-coenzyme A: ...... atic triglyceride mobilization
@en
type
label
Inhibition of acyl-coenzyme A: ...... atic triglyceride mobilization
@ast
Inhibition of acyl-coenzyme A: ...... atic triglyceride mobilization
@en
prefLabel
Inhibition of acyl-coenzyme A: ...... atic triglyceride mobilization
@ast
Inhibition of acyl-coenzyme A: ...... atic triglyceride mobilization
@en
P2093
P2860
P356
P1476
Inhibition of acyl-coenzyme A: ...... atic triglyceride mobilization
@en
P2093
Heather M Alger
J Mark Brown
Janet K Sawyer
Kathryn L Kelley
Lawrence L Rudel
Mark C Willingham
Martha D Wilson
Ramesh Shah
P2860
P304
14267-14274
P356
10.1074/JBC.M110.118422
P407
P577
2010-03-15T00:00:00Z