The human cytomegalovirus IE2 and UL112-113 proteins accumulate in viral DNA replication compartments that initiate from the periphery of promyelocytic leukemia protein-associated nuclear bodies (PODs or ND10)
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Evidence for a role of the cellular ND10 protein PML in mediating intrinsic immunity against human cytomegalovirus infectionsProteasome-independent disruption of PML oncogenic domains (PODs), but not covalent modification by SUMO-1, is required for human cytomegalovirus immediate-early protein IE1 to inhibit PML-mediated transcriptional repression.Epstein-barr virus immediate-early protein BZLF1 is SUMO-1 modified and disrupts promyelocytic leukemia bodiesAbility of the human cytomegalovirus IE1 protein to modulate sumoylation of PML correlates with its functional activities in transcriptional regulation and infectivity in cultured fibroblast cellsEstablishment of papillomavirus infection is enhanced by promyelocytic leukemia protein (PML) expressionAnalysis of human cytomegalovirus-encoded SUMO targets and temporal regulation of SUMOylation of the immediate-early proteins IE1 and IE2 during infectionP-TEFb goes viralFunctional interaction between human herpesvirus 6 immediate-early 2 protein and ubiquitin-conjugating enzyme 9 in the absence of sumoylation.Origin-independent assembly of Kaposi's sarcoma-associated herpesvirus DNA replication compartments in transient cotransfection assays and association with the ORF-K8 protein and cellular PML.Reactivation of the human cytomegalovirus major immediate-early regulatory region and viral replication in embryonal NTera2 cells: role of trichostatin A, retinoic acid, and deletion of the 21-base-pair repeats and modulator.Evaluation of interactions of human cytomegalovirus immediate-early IE2 regulatory protein with small ubiquitin-like modifiers and their conjugation enzyme Ubc9Accumulation and intranuclear distribution of unintegrated human immunodeficiency virus type 1 DNA.Functional interaction of nuclear domain 10 and its components with cytomegalovirus after infections: cross-species host cells versus native cells.Human cytomegalovirus IE1-72 activates ataxia telangiectasia mutated kinase and a p53/p21-mediated growth arrest responseMutations in the M112/M113-coding region facilitate murine cytomegalovirus replication in human cells.Role of noncovalent SUMO binding by the human cytomegalovirus IE2 transactivator in lytic growth.Role of the specific interaction of UL112-113 p84 with UL44 DNA polymerase processivity factor in promoting DNA replication of human cytomegalovirus.The carboxy-terminal segment of the human cytomegalovirus DNA polymerase accessory subunit UL44 is crucial for viral replication.Human cytomegalovirus infection induces specific hyperphosphorylation of the carboxyl-terminal domain of the large subunit of RNA polymerase II that is associated with changes in the abundance, activity, and localization of cdk9 and cdk7.Functional interaction between the pp71 protein of human cytomegalovirus and the PML-interacting protein human Daxx.Interactions among four proteins encoded by the human cytomegalovirus UL112-113 region regulate their intranuclear targeting and the recruitment of UL44 to prereplication fociThe human cytomegalovirus DNA polymerase processivity factor UL44 is modified by SUMO in a DNA-dependent manner.PUL21a-Cyclin A2 interaction is required to protect human cytomegalovirus-infected cells from the deleterious consequences of mitotic entry.Absence of IE1 p72 protein function during low-multiplicity infection by human cytomegalovirus results in a broad block to viral delayed-early gene expression.Placental extravillous cytotrophoblasts persistently express class I major histocompatibility complex molecules after human cytomegalovirus infection.Human cytomegalovirus replication is strictly inhibited by siRNAs targeting UL54, UL97 or UL122/123 gene transcriptsHost-viral effects of chromatin assembly factor 1 interaction with HCMV IE2Resistance to maribavir is associated with the exclusion of pUL27 from nucleoli during human cytomegalovirus infection.Host cell nucleolin is required to maintain the architecture of human cytomegalovirus replication compartments.Sites and roles of phosphorylation of the human cytomegalovirus DNA polymerase subunit UL44.Histone H3 lysine 4 methylation marks postreplicative human cytomegalovirus chromatin.The host ubiquitin-dependent segregase VCP/p97 is required for the onset of human cytomegalovirus replication.Nuclear domain 10-associated proteins recognize and segregate intranuclear DNA/protein complexes to negate gene expressionThe full-length protein encoded by human cytomegalovirus gene UL117 is required for the proper maturation of viral replication compartments.A short cis-acting motif in the M112-113 promoter region is essential for IE3 to activate M112-113 gene expression and is important for murine cytomegalovirus replicationInvolvement of the N-Terminal Deubiquitinating Protease Domain of Human Cytomegalovirus UL48 Tegument Protein in Autoubiquitination, Virion Stability, and Virus Entry.Functional Dissection of an Alternatively Spliced Herpesvirus Gene by Splice Site MutagenesisRecruitment of cdk9 to the immediate-early viral transcriptosomes during human cytomegalovirus infection requires efficient binding to cyclin T1, a threshold level of IE2 86, and active transcription.Role of the proximal enhancer of the major immediate-early promoter in human cytomegalovirus replication.Mouse cytomegalovirus early M112/113 proteins control the repressive effect of IE3 on the major immediate-early promoter.
P2860
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P2860
The human cytomegalovirus IE2 and UL112-113 proteins accumulate in viral DNA replication compartments that initiate from the periphery of promyelocytic leukemia protein-associated nuclear bodies (PODs or ND10)
description
1999 nî lūn-bûn
@nan
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The human cytomegalovirus IE2 ...... nuclear bodies (PODs or ND10)
@ast
The human cytomegalovirus IE2 ...... nuclear bodies (PODs or ND10)
@en
type
label
The human cytomegalovirus IE2 ...... nuclear bodies (PODs or ND10)
@ast
The human cytomegalovirus IE2 ...... nuclear bodies (PODs or ND10)
@en
prefLabel
The human cytomegalovirus IE2 ...... nuclear bodies (PODs or ND10)
@ast
The human cytomegalovirus IE2 ...... nuclear bodies (PODs or ND10)
@en
P2093
P2860
P1433
P1476
The human cytomegalovirus IE2 ...... nuclear bodies (PODs or ND10)
@en
P2093
P2860
P304
10458-10471
P577
1999-12-01T00:00:00Z