about
Screening for BRCA1, BRCA2, CHEK2, PALB2, BRIP1, RAD50, and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast and/or ovarian cancer individualsFunctional link of BRCA1 and ataxia telangiectasia gene product in DNA damage responseAn RNF11: Smurf2 complex mediates ubiquitination of the AMSH proteinHighlight: BRCA1 and BRCA2 proteins in breast cancerHomologous recombination: from model organisms to human disease.BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptorBinding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complexRAD51 localization and activation following DNA damageTranscriptional pathways altered in response to vibration in a model of hand-arm vibration syndromeFine tuning chemotherapy to match BRCA1 statusGene- and genome-based analysis of significant codon patterns in yeast, rat and mice genomes with the CUT Codon UTilization toolHereditary Syndromes Manifesting as Endometrial Carcinoma: How Can Pathological Features Aid Risk Assessment?The transcriptional role of PML and the nuclear bodyBARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear exportEnhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 proteinIdentification and characterization of a tissue-specific coactivator, GT198, that interacts with the DNA-binding domains of nuclear receptors.A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriersPioneering geneticist Mary-Claire King receives the 2014 Lasker~Koshland Special Achievement Award in Medical ScienceIn search of the tumour-suppressor functions of BRCA1 and BRCA2Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells.Heterozygosity for a mutation in Brca1 or Atm does not increase susceptibility to ENU-induced mammary tumors in Apc(Min)/+ mice.Molecular profiles of BRCA1-mutated and matched sporadic breast tumours: relation with clinico-pathological featuresMapping and conformational characterization of the DNA-binding region of the breast cancer susceptibility protein BRCA1.Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers.Genetic and epigenetic silencing of the beclin 1 gene in sporadic breast tumorsAltered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutationsReverse genetic studies of homologous DNA recombination using the chicken B-lymphocyte line, DT40.A network-based biomarker approach for molecular investigation and diagnosis of lung cancer.BRCA1 and BRCA2 mutations and treatment strategies for breast cancer.BRCA-associated ovarian cancer: from molecular genetics to risk managementSpecific aspects of the ubiquitin system in spermatogenesis.High BRCA2 mRNA expression predicts poor prognosis in breast cancer patients.Collaboration of Brca1 and Chk2 in tumorigenesis.Inactivating Mutations in GT198 in Familial and Early-Onset Breast and Ovarian Cancers.Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletionsCancer: the evolved consequence of a destabilized genome.Challenges in Biomarker Discovery: Combining Expert Insights with Statistical Analysis of Complex Omics Data.Inherited predisposition and breast cancer: modifiers of BRCA1/2-associated breast cancer risk.The effectiveness of cucurbitacin B in BRCA1 defective breast cancer cells.Detection of BRCA1 and BRCA2 mutations in a selected Hawaii population.
P2860
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P2860
description
2000 nî lūn-bûn
@nan
2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Insights into the functions of BRCA1 and BRCA2.
@ast
Insights into the functions of BRCA1 and BRCA2.
@en
type
label
Insights into the functions of BRCA1 and BRCA2.
@ast
Insights into the functions of BRCA1 and BRCA2.
@en
prefLabel
Insights into the functions of BRCA1 and BRCA2.
@ast
Insights into the functions of BRCA1 and BRCA2.
@en
P2093
P1433
P1476
Insights into the functions of BRCA1 and BRCA2.
@en
P2093
P356
10.1016/S0168-9525(99)01930-7
P577
2000-02-01T00:00:00Z