Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.
about
Dendritic spine dysgenesis in autism related disordersDown Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 HomologuesNebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signalingEvidence of long-term gene flow and selection during domestication from analyses of Eurasian wild and domestic pig genomesDSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesisMeeting at the crossroads: common mechanisms in Fragile X and Down syndromeOver-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory.NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effectThe use of mouse models for understanding the biology of down syndrome and agingBidirectional Regulation of Amyloid Precursor Protein-Induced Memory Defects by Nebula/DSCR1: A Protein Upregulated in Alzheimer's Disease and Down SyndromeDSCR1 is required for both axonal growth cone extension and steering.Allele-Specific Phenotype Suggests a Possible Stimulatory Activity of RCAN-1 on Calcineurin in Caenorhabditis elegans.Chronic high levels of the RCAN1-1 protein may promote neurodegeneration and Alzheimer disease.Aberrant expression of RCAN1 in Alzheimer's pathogenesis: a new molecular mechanism and a novel drug target.RCAN1 overexpression promotes age-dependent mitochondrial dysregulation related to neurodegeneration in Alzheimer's disease.Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.Developmental exposure to paraquat and maneb can impair cognition, learning and memory in Sprague-Dawley rats.Dysfunction in endoplasmic reticulum-mitochondria crosstalk underlies SIGMAR1 loss of function mediated motor neuron degeneration.
P2860
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P2860
Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.
@ast
Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.
@en
type
label
Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.
@ast
Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.
@en
prefLabel
Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.
@ast
Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.
@en
P2093
P2860
P50
P1433
P1476
Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1
@en
P2093
Carmen Martínez-Cué
Cristina Fillat
Jerome McDonald
Jesús Flórez
P2860
P304
P356
10.1371/JOURNAL.PONE.0017010
P407
P577
2011-02-25T00:00:00Z