Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation. - Wikidata - wikimedia - TriplyDB

Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation.

Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation.

http://www.wikidata.org/entity/Q34685048

about

Dissecting Alzheimer disease in Down syndrome using mouse models Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signaling Early mechanisms of pathobiology are revealed by transcriptional temporal dynamics in hippocampal CA1 neurons of prion infected mice RCAN1 Overexpression Exacerbates Calcium Overloading-Induced Neuronal Apoptosis Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.Commonality in Down and fetal alcohol syndromes.Extracellular ATP activates NFAT-dependent gene expression in neuronal PC12 cells via P2X receptors Hsp90 is involved in apoptosis of Candida albicans by regulating the calcineurin-caspase apoptotic pathway.RCAN1 is an important mediator of glucocorticoid-induced apoptosis in human leukemic cells.Overexpression of Rcan1-1L inhibits hypoxia-induced cell apoptosis through induction of mitophagy High glucose promotes Aβ production by inhibiting APP degradation.Fecal corticosterone levels in RCAN1 mutant mice Functional genomic analysis of variation on beef tenderness induced by acute stress in angus cattle.Chronic expression of RCAN1-1L protein induces mitochondrial autophagy and metabolic shift from oxidative phosphorylation to glycolysis in neuronal cells.Bidirectional Regulation of Amyloid Precursor Protein-Induced Memory Defects by Nebula/DSCR1: A Protein Upregulated in Alzheimer's Disease and Down Syndrome Influence of MiR-451 on Drug Resistances of Paclitaxel-Resistant Breast Cancer Cell Line.The RCAN1 inhibits NF-κB and suppresses lymphoma growth in mice Regulation of global gene expression and cell proliferation by APP The calcineurin inhibitor Sarah (Nebula) exacerbates Aβ42 phenotypes in a Drosophila model of Alzheimer's disease.The genomically mosaic brain: aneuploidy and more in neural diversity and disease.Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype.The regulator of calcineurin 1 (RCAN1) inhibits nuclear factor kappaB signaling pathway and suppresses human malignant glioma cells growth.Chronic high levels of the RCAN1-1 protein may promote neurodegeneration and Alzheimer disease.Aberrant expression of RCAN1 in Alzheimer's pathogenesis: a new molecular mechanism and a novel drug target.The regulator of calcineurin (RCAN1) an important factor involved in atherosclerosis and cardiovascular diseases development.RCAN1 overexpression promotes age-dependent mitochondrial dysregulation related to neurodegeneration in Alzheimer's disease.Glucocorticoid-mediated co-regulation of RCAN1-1, E4BP4 and BIM in human leukemia cells susceptible to apoptosis.Upregulation of SET expression by BACE1 and its implications in Down syndrome.Critical role of regulator of calcineurin 1 in spinal cord injury.The regulator of calcineurin 1 increases adenine nucleotide translocator 1 and leads to mitochondrial dysfunctions.Modifications and Trafficking of APP in the Pathogenesis of Alzheimer's Disease.Transcription factor NF-kappa B represses ANT1 transcription and leads to mitochondrial dysfunctions The neuronal and endocrine roles of RCAN1 in health and disease.Lycopene inhibits regulator of calcineurin 1-mediated apoptosis by reducing oxidative stress and down-regulating Nucling in neuronal cells.Dynamic expression changes of Bcl-2, Caspase-3 and Hsp70 in middle cerebral artery occlusion rats.RCAN1 in the inverse association between Alzheimer's disease and cancer.RCAN1 Mutation and Functional Characterization in Children with Sporadic Congenital Heart Disease.BACE2 degradation mediated by the macroautophagy-lysosome pathway.Secretion of Down Syndrome Critical Region 1 Isoform 4 in Ischemic Retinal Ganglion Cells Displays Anti-Angiogenic Properties Via NFATc1-Dependent Pathway.A Novel Alzheimer-Associated SNP in Tmp21 Increases Amyloidogenesis.

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Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation.

http://www.wikidata.org/entity/Q34685048

description

2011 nî lūn-bûn

@nan

2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

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2011年论文

@wuu

name

Regulator of calcineurin 1 (RC ...... through caspase-3 activation.

@ast

Regulator of calcineurin 1 (RC ...... through caspase-3 activation.

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Regulator of calcineurin 1

@nl

type

label

Regulator of calcineurin 1 (RC ...... through caspase-3 activation.

@ast

Regulator of calcineurin 1 (RC ...... through caspase-3 activation.

@en

Regulator of calcineurin 1

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prefLabel

Regulator of calcineurin 1 (RC ...... through caspase-3 activation.

@ast

Regulator of calcineurin 1 (RC ...... through caspase-3 activation.

@en

Regulator of calcineurin 1

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JBC.M110.177519

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Journal of Biological Chemistry

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Regulator of calcineurin 1 (RC ...... through caspase-3 activation.

@en

P2093

Bin Chen

http://www.w3.org/2001/XMLSchema#string

Junying Yuan

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Kun Xia

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Richard A Flavell

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Weihui Zhou

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Xiulian Sun

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Zhuohua Zhang

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P2860

A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart

Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life

Pathways towards and away from Alzheimer's disease

Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

Calcineurin functions in Ca(2+)-activated cell death in mammalian cells

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

Mechanisms of caspase activation and inhibition during apoptosis.

DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways

A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

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9049-9062

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10.1074/JBC.M110.177519

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11

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Hinrich Gronemeyer

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2011-01-07T00:00:00Z

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49738999

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21216952

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3059004

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