about
TMC207: the first compound of a new class of potent anti-tuberculosis drugsEnhancing hit identification in Mycobacterium tuberculosis drug discovery using validated dual-event Bayesian modelsLooking back to the future: predicting in vivo efficacy of small molecules versus Mycobacterium tuberculosisBigger data, collaborative tools and the future of predictive drug discoveryCombining cheminformatics methods and pathway analysis to identify molecules with whole-cell activity against Mycobacterium tuberculosisOpen Drug Discovery Teams: A Chemistry Mobile App for CollaborationFusing dual-event data sets for Mycobacterium tuberculosis machine learning models and their evaluation.Are bigger data sets better for machine learning? Fusing single-point and dual-event dose response data for Mycobacterium tuberculosisAnalysis and hit filtering of a very large library of compounds screened against Mycobacterium tuberculosis.Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists.Validating new tuberculosis computational models with public whole cell screening aerobic activity datasets.Computational databases, pathway and cheminformatics tools for tuberculosis drug discovery.Essential metabolites of Mycobacterium tuberculosis and their mimicsBayesian models leveraging bioactivity and cytotoxicity information for drug discovery.Combining computational methods for hit to lead optimization in Mycobacterium tuberculosis drug discovery.Bayesian models for screening and TB Mobile for target inference with Mycobacterium tuberculosis.In-silico Metabolome Target Analysis Towards PanC-based Antimycobacterial Agent Discovery.Synergistic activity of R207910 combined with pyrazinamide against murine tuberculosisKey issues in multidrug-resistant tuberculosis.Predictive modeling targets thymidylate synthase ThyX in Mycobacterium tuberculosisIn vitro evaluation of tetrazoles as a novel class of Antimycobacterium tuberculosis agents.Recent advances in antituberculous drug development and novel drug targets.Pharmacological significance of triazole scaffold.Recent advances in the research of heterocyclic compounds as antitubercular agents.Development of cyclobutene- and cyclobutane-functionalized fatty acids with inhibitory activity against Mycobacterium tuberculosis.Diarylquinolines, synthesis pathways and quantitative structure--activity relationship studies leading to the discovery of TMC207.Development of new antituberculous agents based on new drug targets and structure-activity relationship.Synthesis and Antimicrobial Activity of N,N'-Bis(2-hydroxylbenzyl)-1,2-ethanediamine Derivatives.Sugar nucleotide recognition by Klebsiella pneumoniae UDP-D-galactopyranose mutase: fluorinated substrates, kinetics and equilibria.Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp.Sterilizing activity of R207910 (TMC207)-containing regimens in the murine model of tuberculosis.Microwave-Assisted ZrSiO2 Catalysed Synthesis, Characterization and Computational Study of Novel Spiro[Indole-Thiazolidines] Derivatives as Anti-tubercular Agents.A Novel and Efficient Five-Component Synthesis of Pyrazole Based Pyrido[2,3-d]pyrimidine-diones in Water: A Triply Green Synthesis.Antimycobacterial evaluation of novel [4,5-dihydro-1H-pyrazole-1-carbonyl]pyridine derivatives synthesized by microwave-mediated Michael addition.Structural insight into Mycobacterium tuberculosis maltosyl transferase inhibitors: pharmacophore-based virtual screening, docking, and molecular dynamics simulations.Pioneering Use of the Cloud for Development of Collaborative Drug Discovery (CDD) Database
P2860
Q24632091-1205C36F-9306-46D4-AE04-18898673FEDEQ28487748-1484CEE0-34F9-4DCC-963B-6F7B9479F191Q28538272-C8622C85-E891-4191-B7D8-135136CDB12FQ28654673-2B67E14E-0756-429B-8705-FAD55A254ECEQ28709665-74F721FF-2BA8-4191-82D9-20374ECC96ECQ28710563-D9D52621-80BD-4A72-A25F-5508B4051E90Q30681280-C6AA2FB9-06D7-409E-BA2C-966F3CA01E07Q30833510-38F55BA0-9A71-49EE-B7C5-23BD47F44D96Q33690587-F1B48013-09AF-479F-9946-B93D5663D2F7Q33756500-D1D0BAD2-C238-4674-BBBA-1DFDCB2FB89DQ33891020-8E3972BD-0502-484B-9356-9B1AF059814BQ34153280-DB65D00A-52CE-4C83-92F4-06B296B0329EQ34162040-9D13718F-D031-4E95-9ACF-FE9D7706F89DQ34632430-79E6EBED-1B89-444B-A274-9C25AA8C764FQ35019457-7574F7D9-181C-4275-A806-5DF66764E41CQ35374554-924E0161-B053-4605-B81A-9DE92737208AQ35538689-91DB76BD-C773-4BA9-92D8-86B9558F50BEQ35647811-A9152BA2-9AD5-485B-B836-C40E72058362Q36895711-FF6299F8-0733-43BB-9778-03460085748EQ36990690-55AD6E2A-AFA6-4633-BBF7-D69FEA1FB8BDQ37354776-4CE75D03-BF2B-42B7-9924-E2BB2DA93853Q37754884-2A891CEF-2AA0-42F8-8E3F-48DB4D2379D6Q37768161-AA15861C-5D7B-4881-A381-FCDCB725CBFDQ38050102-DB4A2C4C-4E7A-44CC-8C44-03B1CDD62C3AQ38987867-0E1C5A4E-1A06-4E63-9DF5-91D3BADAEB71Q39712350-A7822BB4-FE7A-4AD7-A1D2-6382D57DB885Q40138610-80E24F99-76DF-4FB5-BFE0-34AC6A558FFAQ41002140-89C08A93-9F9E-462E-A6E1-6EF9AC0C0527Q41771088-9871A77C-3D7F-471C-AE02-F16C83D43C9FQ45930412-7A84AF06-82CD-4102-9C26-B8307F81F8AAQ45933567-A72BED5A-A919-405F-A537-889CC14B7300Q50215316-D33A3E16-1BFA-45C0-9532-A9B6EA7E88E7Q50230523-48280870-F9B0-45C2-8A9B-86E3D4178BFEQ50449598-30DA9F33-C539-4D12-9699-F314AD3AEB37Q50960965-BD859B84-10A4-4D2A-BC01-A87254649430Q56511193-B638B69E-519D-4CCE-88DB-719ED2B8D3A8
P2860
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
New small-molecule synthetic antimycobacterials.
@ast
New small-molecule synthetic antimycobacterials.
@en
type
label
New small-molecule synthetic antimycobacterials.
@ast
New small-molecule synthetic antimycobacterials.
@en
prefLabel
New small-molecule synthetic antimycobacterials.
@ast
New small-molecule synthetic antimycobacterials.
@en
P2093
P2860
P1476
New small-molecule synthetic antimycobacterials.
@en
P2093
Ken Duncan
Robert A Field
Robert J Young
P2860
P304
P356
10.1128/AAC.49.6.2153-2163.2005
P407
P577
2005-06-01T00:00:00Z