Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism
about
Acute overactive endocannabinoid signaling induces glucose intolerance, hepatic steatosis, and novel cannabinoid receptor 1 responsive genesActivity-based proteomics of enzyme superfamilies: serine hydrolases as a case studyChemical probes of endocannabinoid metabolismTherapeutic potential of monoacylglycerol lipase inhibitorsA lipid gate for the peripheral control of painThe pharmacological landscape and therapeutic potential of serine hydrolasesMonoacylglycerol lipase - a target for drug development?Reversible Competitive α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Constraints in the Acyl Side Chain: Orally Active, Long-Acting AnalgesicsIdentification of Yju3p as functional orthologue of mammalian monoglyceride lipase in the yeast Saccharomycescerevisiae.Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase: New Targets for Future AntidepressantsNew mechanisms and perspectives in nicotine withdrawalFull Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in MiceThe serine hydrolase ABHD6 Is a critical regulator of the metabolic syndromeMonoacylglycerol lipase (MAGL) inhibition attenuates acute lung injury in miceMonoacylglycerols activate TRPV1--a link between phospholipase C and TRPV1Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system.Metabolically Labile Fumarate Esters Impart Kinetic Selectivity to Irreversible InhibitorsDual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents.Lactobacillus rhamnosus lowers zebrafish lipid content by changing gut microbiota and host transcription of genes involved in lipid metabolism.Interacting Cannabinoid and Opioid Receptors in the Nucleus Accumbens Core Control Adolescent Social Play.Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2Peripheral gating of pain signals by endogenous lipid mediators.Monoacylglycerol lipase inhibition blocks chronic stress-induced depressive-like behaviors via activation of mTOR signaling.Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases.Dietary lipid content reorganizes gut microbiota and probiotic L. rhamnosus attenuates obesity and enhances catabolic hormonal milieu in zebrafish.Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis.Prolonged monoacylglycerol lipase blockade causes equivalent cannabinoid receptor type 1 receptor-mediated adaptations in fatty acid amide hydrolase wild-type and knockout miceEndocannabinoid contribution to Δ9-tetrahydrocannabinol discrimination in rodentsMetabolomic strategies to map functions of metabolic pathwaysStrategies for discovering and derisking covalent, irreversible enzyme inhibitors.The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).Endocannabinoids in synaptic plasticity and neuroprotection.The dual FAAH/MAGL inhibitor JZL195 has enhanced effects on endocannabinoid transmission and motor behavior in rats as compared to those of the MAGL inhibitor JZL184Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoidsBiosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol.Cyclooxygenase-2 mediates anandamide metabolism in the mouse brainConfirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probesEndocannabinoid 2-Arachidonoylglycerol Self-Administration by Sprague-Dawley Rats and Stimulation of in vivo Dopamine Transmission in the Nucleus Accumbens Shell.Synaptic and cognitive improvements by inhibition of 2-AG metabolism are through upregulation of microRNA-188-3p in a mouse model of Alzheimer's disease.
P2860
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P2860
Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Characterization of monoacylgl ...... ral endocannabinoid metabolism
@ast
Characterization of monoacylgl ...... ral endocannabinoid metabolism
@en
type
label
Characterization of monoacylgl ...... ral endocannabinoid metabolism
@ast
Characterization of monoacylgl ...... ral endocannabinoid metabolism
@en
prefLabel
Characterization of monoacylgl ...... ral endocannabinoid metabolism
@ast
Characterization of monoacylgl ...... ral endocannabinoid metabolism
@en
P2860
P1476
Characterization of monoacylgl ...... ral endocannabinoid metabolism
@en
P2093
Daniel K Nomura
Jonathan Z Long
P2860
P304
P356
10.1016/J.CHEMBIOL.2009.05.009
P577
2009-07-01T00:00:00Z