Human immunodeficiency virus 1 protease expressed in Escherichia coli behaves as a dimeric aspartic protease. - Wikidata - wikimedia - TriplyDB

Human immunodeficiency virus 1 protease expressed in Escherichia coli behaves as a dimeric aspartic protease.

Human immunodeficiency virus 1 protease expressed in Escherichia coli behaves as a dimeric aspartic protease.

http://www.wikidata.org/entity/Q33843249

about

Identification and characterization of a novel retroviral-like aspartic protease specifically expressed in human epidermis P2' Benzene Carboxylic Acid Moiety Is Associated with Decrease in Cellular Uptake: Evaluation of Novel Nonpeptidic HIV-1 Protease Inhibitors Containing P2 bis-Tetrahydrofuran Moiety Thioltransferase (glutaredoxin) is detected within HIV-1 and can regulate the activity of glutathionylated HIV-1 protease in vitro In vitro inhibition of HIV-1 proteinase by cerulenin Copper inhibits the protease from human immunodeficiency virus 1 by both cysteine-dependent and cysteine-independent mechanisms An inhibitor of the protease blocks maturation of human and simian immunodeficiency viruses and spread of infection Inhibition of human immunodeficiency virus 1 protease in vitro: rational design of substrate analogue inhibitors Antiretroviral activities of protease inhibitors against murine leukemia virus and simian immunodeficiency virus in tissue culture Molecular modeling studies suggest that zinc ions inhibit HIV-1 protease by binding at catalytic aspartates FINDSITE: a threading-based approach to ligand homology modeling Conserved cysteines of the human immunodeficiency virus type 1 protease are involved in regulation of polyprotein processing and viral maturation of immature virions Isolation of mutants of human immunodeficiency virus protease based on the toxicity of the enzyme in Escherichia coli.Stability and activity of human immunodeficiency virus protease: comparison of the natural dimer with a homologous, single-chain tethered dimer.Applications of 3-aminolactams: design, synthesis, and biological evaluation of a library of potential dimerisation inhibitors of HIV1-protease.Strategies for assessing proton linkage to bimolecular interactions by global analysis of isothermal titration calorimetry data Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HIV-1 protease.Development of inhibitors of reverse transcriptase and protease as therapeutics against HIV infection.Protocol for rational design of covalently interacting inhibitors.The SIVmac239 Pr55Gag isoform, SIV p43, suppresses proteolytic cleavage of Pr55Gag.Defining the level of human immunodeficiency virus type 1 (HIV-1) protease activity required for HIV-1 particle maturation and infectivity Sequence requirements of the HIV-1 protease flap region determined by saturation mutagenesis and kinetic analysis of flap mutants Proteolytic activity of novel human immunodeficiency virus type 1 proteinase proteins from a precursor with a blocking mutation at the N terminus of the PR domain.Human immunodeficiency virus type 1 gag-protease fusion proteins are enzymatically active.Overexpression of the gag-pol precursor from human immunodeficiency virus type 1 proviral genomes results in efficient proteolytic processing in the absence of virion production HIV-1 protease as a potential target for anti-AIDS therapy.Isolation and characterization of recombinant Drosophila Copia aspartic proteinase.Impact of Stereochemistry on Ligand Binding: X-ray Crystallographic Analysis of an Epoxide-Based HIV Protease Inhibitor.Novel bacteriological assay for detection of potential antiviral agents.Proteolytic processing of Ty3 proteins is required for transposition.Specific inhibitor of human immunodeficiency virus proteinase prevents the cytotoxic effects of a single-chain proteinase dimer and restores particle formation.Identification and characterization of human immunodeficiency virus type 1 gag-pol fusion protein in transfected mammalian cells.Insights into saquinavir resistance in the G48V HIV-1 protease: quantum calculations and molecular dynamic simulations.Cloning and Expression of Soluble Recombinant HIV-1 CRF35 Protease-HP Thioredoxin Fusion Protein.Viral gene products and replication of the human immunodeficiency type 1 virus.Interactions of a novel inhibitor from an extremophilic Bacillus sp. with HIV-1 protease: implications for the mechanism of inactivation.Is the pseudo-dyad in retroviral proteinase monomers structural or evolutionary?Inhibitory effects of Korean medicinal plants and camelliatannin H from Camellia japonica on human immunodeficiency virus type 1 protease.Purification and characterization of human T-cell leukemia virus type I protease produced in Escherichia coli.Competitive inhibition of human immunodeficiency virus type-1 protease by the Gag-Pol transframe protein.Dimerization and activation of the herpes simplex virus type 1 protease.

P2860

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P2860

Human immunodeficiency virus 1 protease expressed in Escherichia coli behaves as a dimeric aspartic protease.

http://www.wikidata.org/entity/Q33843249

description

1989 nî lūn-bûn

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1989 թուականի Մարտին հրատարակուած գիտական յօդուած

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1989 թվականի մարտին հրատարակված գիտական հոդված

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1989年の論文

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1989年論文

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1989年論文

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1989年論文

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1989年論文

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1989年論文

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1989年论文

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name

Human immunodeficiency virus 1 ...... s a dimeric aspartic protease.

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Human immunodeficiency virus 1 ...... s a dimeric aspartic protease.

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type

label

Human immunodeficiency virus 1 ...... s a dimeric aspartic protease.

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Human immunodeficiency virus 1 ...... s a dimeric aspartic protease.

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prefLabel

Human immunodeficiency virus 1 ...... s a dimeric aspartic protease.

@ast

Human immunodeficiency virus 1 ...... s a dimeric aspartic protease.

@en

P1433

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P2860

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P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Human immunodeficiency virus 1 ...... s a dimeric aspartic protease.

@en

P2093

B D Dayton

http://www.w3.org/2001/XMLSchema#string

B W Metcalf

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C Debouck

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G B Dreyer

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J E Strickler

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J G Gorniak

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M L Moore

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M Rosenberg

http://www.w3.org/2001/XMLSchema#string

T D Meek

http://www.w3.org/2001/XMLSchema#string

V W Magaard

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P2860

Active human immunodeficiency virus protease is required for viral infectivity

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Nucleotide sequence of the AIDS virus, LAV

Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases

An 11-kDa form of human immunodeficiency virus protease expressed in Escherichia coli is sufficient for enzymatic activity.

Use of dimethyl suberimidate, a cross-linking reagent, in studying the subunit structure of oligomeric proteins.

Purification and properties of a transcriptional activator. The cII protein of phage lambda.

Human immunodeficiency virus protease expressed in Escherichia coli exhibits autoprocessing and specific maturation of the gag precursor.

Statistical analysis of enzyme kinetic data.

Bovine leukemia virus protease: purification, chemical analysis, and in vitro processing of gag precursor polyproteins

P304

1841-1845

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P31

scholarly article

P356

10.1073/PNAS.86.6.1841

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P407

P433

6

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P478

86

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P577

1989-03-01T00:00:00Z

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P5875

20508605

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P698

2648384

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P921

Escherichia coli

P932

286800

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