Destabilization of the retinoblastoma tumor suppressor by human papillomavirus type 16 E7 is not sufficient to overcome cell cycle arrest in human keratinocytes.
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Targeting mechanism of the retinoblastoma tumor suppressor by a prototypical viral oncoprotein. Structural modularity, intrinsic disorder and phosphorylation of human papillomavirus E7Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600USP11 stabilizes HPV-16E7 and further modulates the E7 biological activityIdentification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complexThe association of mammalian DREAM complex and HPV16 E7 proteinsAPC/C and retinoblastoma interaction: cross-talk of retinoblastoma protein with the ubiquitin proteasome pathwayFunctional Roles of E6 and E7 Oncoproteins in HPV-Induced Malignancies at Diverse Anatomical SitesThe canine papillomavirus and gamma HPV E7 proteins use an alternative domain to bind and destabilize the retinoblastoma protein.Human papillomavirus type 16 E7 binds to E2F1 and activates E2F1-driven transcription in a retinoblastoma protein-independent manner.The human papillomavirus type 58 E7 oncoprotein modulates cell cycle regulatory proteins and abrogates cell cycle checkpoints.Critical roles for non-pRb targets of human papillomavirus type 16 E7 in cervical carcinogenesisHuman papillomavirus E7 oncoprotein overrides the tumor suppressor activity of p21Cip1 in cervical carcinogenesis.HPV31 E7 facilitates replication by activating E2F2 transcription through its interaction with HDACsPotent anti-tumor effect generated by a novel human papillomavirus (HPV) antagonist peptide reactivating the pRb/E2F pathway.Examination of the pRb-dependent and pRb-independent functions of E7 in vivo.Interactions with pocket proteins contribute to the role of human papillomavirus type 16 E7 in the papillomavirus life cycle.The E7 proteins of low- and high-risk human papillomaviruses share the ability to target the pRB family member p130 for degradationThree regions of the pRB pocket domain affect its inactivation by human papillomavirus E7 proteins.Lactate transporters and vascular factors in HPV-induced squamous cell carcinoma of the uterine cervix.Inactivation of both the retinoblastoma tumor suppressor and p21 by the human papillomavirus type 16 E7 oncoprotein is necessary to inhibit cell cycle arrest in human epithelial cells.Biological activities and molecular targets of the human papillomavirus E7 oncoprotein.The high-risk HPV16 E7 oncoprotein mediates interaction between the transcriptional coactivator CBP and the retinoblastoma protein pRb.Nonconserved lysine residues attenuate the biological function of the low-risk human papillomavirus E7 proteinRecapitulation of the effects of the human papillomavirus type 16 E7 oncogene on mouse epithelium by somatic Rb deletion and detection of pRb-independent effects of E7 in vivoThe E7 open reading frame acts in cis and in trans to mediate differentiation-dependent activities in the human papillomavirus type 16 life cycle.Systematic analysis of the amino acid residues of human papillomavirus type 16 E7 conserved region 3 involved in dimerization and transformation.Mechanisms of human papillomavirus-induced oncogenesis.Human papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressorHuman papillomaviruses: shared and distinct pathways for pathogenesisAssociation between hTERT activation by HPV E6 proteins and oncogenic risk.Conserved region 3 of human papillomavirus 16 E7 contributes to deregulation of the retinoblastoma tumor suppressor.HPV 16E7 and 48E7 proteins use different mechanisms to target p130 to overcome cell cycle blockZinc finger arrays binding human papillomavirus types 16 and 18 genomic DNA: precursors of gene-therapeutics for in-situ reversal of associated cervical neoplasiaHuman papillomavirus E7 induces rereplication in response to DNA damageLow-penetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant rasCellular transformation by human papillomaviruses: lessons learned by comparing high- and low-risk virusesThe binding of histone deacetylases and the integrity of zinc finger-like motifs of the E7 protein are essential for the life cycle of human papillomavirus type 31.Regulation of the retinoblastoma proteins by the human herpesviruses.Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivoThe papillomavirus E7 proteins.
P2860
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P2860
Destabilization of the retinoblastoma tumor suppressor by human papillomavirus type 16 E7 is not sufficient to overcome cell cycle arrest in human keratinocytes.
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Destabilization of the retinob ...... arrest in human keratinocytes.
@ast
Destabilization of the retinob ...... arrest in human keratinocytes.
@en
type
label
Destabilization of the retinob ...... arrest in human keratinocytes.
@ast
Destabilization of the retinob ...... arrest in human keratinocytes.
@en
prefLabel
Destabilization of the retinob ...... arrest in human keratinocytes.
@ast
Destabilization of the retinob ...... arrest in human keratinocytes.
@en
P2860
P1433
P1476
Destabilization of the retinob ...... arrest in human keratinocytes.
@en
P2093
D A Galloway
P2860
P304
P356
10.1128/JVI.75.15.6737-6747.2001
P577
2001-08-01T00:00:00Z