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Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo

Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo

http://www.wikidata.org/entity/Q37116215

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The human DEK oncogene regulates DNA damage response signaling and repair Dissecting the Potential Interplay of DEK Functions in Inflammation and Cancer Histone-modifying enzymes, histone modifications and histone chaperones in nucleosome assembly: Lessons learned from Rtt109 histone acetyltransferases Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma.The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer DEK associates with tumor stage and outcome in HPV16 positive oropharyngeal squamous cell carcinoma.Overexpression of the human DEK oncogene reprograms cellular metabolism and promotes glycolysis Environmental-stress-induced Chromatin Regulation and its Heritability Oncoprotein DEK as a tissue and urinary biomarker for bladder cancer.High-affinity interaction of poly(ADP-ribose) and the human DEK oncoprotein depends upon chain length.Control of tumorigenesis and chemoresistance by the DEK oncogene DEK promotes HPV-positive and -negative head and neck cancer cell proliferation.An essential role of variant histone H3.3 for ectomesenchyme potential of the cranial neural crest FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation.Histone chaperones in nucleosome assembly and human disease The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity.The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers DEK over expression as an independent biomarker for poor prognosis in colorectal cancer.The human DEK oncogene stimulates β-catenin signaling, invasion and mammosphere formation in breast cancer.The DEK oncoprotein binds to highly and ubiquitously expressed genes with a dual role in their transcriptional regulation.Mechanisms underlying cancer growth and apoptosis by DEK overexpression in colorectal cancer.Effects of human papillomavirus (HPV) type 16 oncoproteins on the expression of involucrin in human keratinocytes Future directions and treatment strategies for head and neck squamous cell carcinomas DEK is required for homologous recombination repair of DNA breaks.DEK protein level is a biomarker of CD138positive normal and malignant plasma cells.A genome-wide assessment of rare copy number variants in colorectal cancer.Expression level of DEK in chronic lymphocytic leukemia is regulated by fludarabine and Nutlin-3 depending on p53 status.Stacking the DEK: from chromatin topology to cancer stem cells.Overexpression of DEK is an indicator of poor prognosis in patients with gastric adenocarcinoma.The role of DEK protein in hepatocellular carcinoma for progression and prognosis.The DEK oncogene activates VEGF expression and promotes tumor angiogenesis and growth in HIF-1α-dependent and -independent manners.Critical role of DEK and its regulation in tumorigenesis and metastasis of hepatocellular carcinoma.Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer Progress in studies on the DEK protein and its involvement in cellular apoptosis.Concise review: role of DEK in stem/progenitor cell biology The DEK oncoprotein and its emerging roles in gene regulation.Emerging roles for the FBXW7 ubiquitin ligase in leukemia and beyond.Promotion of cell proliferation by the proto-oncogene DEK enhances oral squamous cell carcinogenesis through field cancerization DEK proto-oncogene is highly expressed in astrocytic tumors and regulates glioblastoma cell proliferation and apoptosis.The human oncoprotein and chromatin architectural factor DEK counteracts DNA replication stress.

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Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo

http://www.wikidata.org/entity/Q37116215

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scientific article published on 17 February 2009

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Overexpression of the cellular ...... formation in vitro and in vivo

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Overexpression of the cellular ...... formation in vitro and in vivo

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Overexpression of the cellular ...... ormation in vitro and in vivo.

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Overexpression of the cellular ...... formation in vitro and in vivo

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Overexpression of the cellular ...... ormation in vitro and in vivo.

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0008-5472.CAN-08-2304

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Cancer Research

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Overexpression of the cellular ...... formation in vitro and in vivo

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David S Simpson

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Gerard C Grosveld

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Kathryn A Wikenheiser-Brokamp

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Mark A Currier

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Rachael A Mintz-Cole

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Susanne I Wells

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Teresa A Morris

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Timothy P Cripe

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P2860

Amplification and overexpression of the ID4 gene at 6p22.3 in bladder cancer.

Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

Transcriptional activation by AP-2alpha is modulated by the oncogene DEK

The protein encoded by the proto-oncogene DEK changes the topology of chromatin and reduces the efficiency of DNA replication in a chromatin-specific manner

The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA

The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes

Subcellular localization of the human proto-oncogene protein DEK

Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis

IL-23 promotes tumour incidence and growth

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1792-1799

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10.1158/0008-5472.CAN-08-2304

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5

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Trisha M Wise-Draper

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2009-02-17T00:00:00Z

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19223548

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