Optineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation.
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Oligomerization of optineurin and its oxidative stress- or E50K mutation-driven covalent cross-linking: possible relationship with glaucoma pathologyPathobiology of Paget's Disease of BoneFunctional analysis of optineurin and some of its disease-associated mutantsLoss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamicsMitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degenerationA Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of OptineurinM98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cellsE3-14.7K is recruited to TNF-receptor 1 and blocks TNF cytolysis independent from interaction with optineurinE50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy.Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin gene.Optineurin regulates the interferon response in a cell cycle-dependent mannerOptineurin Negatively Regulates Osteoclast Differentiation by Modulating NF-κB and Interferon Signaling: Implications for Paget's DiseaseOptineurin: The autophagy connection.Cellular and molecular biology of optineurin.Optineurin insufficiency impairs IRF3 but not NF-κB activation in immune cells.Effects of mutations and deletions in the human optineurin gene.TNF and ubiquitin at the crossroads of gene activation, cell death, inflammation, and cancer.Regulation of NF-κB by deubiquitinases.Pathogenesis of Paget disease of bone.Toward an integrative view of Optineurin functions.Biology and Treatment of Paget's Disease of Bone.Formation and removal of poly-ubiquitin chains in the regulation of tumor necrosis factor-induced gene activation and cell death.The Outflow Pathway: A Tissue With Morphological and Functional Unity.Interaction between optineurin and Rab1a regulates autophagosome formation in neuroblastoma cells.LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes.CYLD, A20 and OTULIN deubiquitinases in NF-κB signaling and cell death: so similar, yet so different.Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.Visual impairment in an optineurin mouse model of primary open-angle glaucoma.Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling.Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug targetFrom the Cover: Alterations in Optineurin Expression and Localization in Pre-clinical Parkinson's Disease ModelsThe evolution and functional diversification of the deubiquitinating enzyme superfamily.Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein.Identification of optineurin as an interleukin-1 receptor-associated kinase 1-binding protein and its role in regulation of MyD88-dependent signaling.Optineurin Functions for Optimal Immunity.Optineurin: A Coordinator of Membrane-Associated Cargo Trafficking and Autophagy.The Selective Autophagy Receptor Optineurin in Crohn's Disease.Molecular effect of an OPTN common variant associated to Paget's disease of bone.Dysfunction of Optineurin in Amyotrophic Lateral Sclerosis and Glaucoma.Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin.
P2860
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P2860
Optineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Optineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation.
@ast
Optineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation.
@en
type
label
Optineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation.
@ast
Optineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation.
@en
prefLabel
Optineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation.
@ast
Optineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation.
@en
P2860
P1433
P1476
Optineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation.
@en
P2093
Ananthamurthy Nagabhushana
Megha Bansal
P2860
P304
P356
10.1371/JOURNAL.PONE.0017477
P407
P577
2011-03-07T00:00:00Z