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Oligomerization of optineurin and its oxidative stress- or E50K mutation-driven covalent cross-linking: possible relationship with glaucoma pathologyUbiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppressionNew Insights into How Trafficking Regulates T Cell Receptor SignalingUltrastructural studies of ALS mitochondria connect altered function and permeability with defects of mitophagy and mitochondriogenesisPaget's disease of bone: an osteoimmunological disorder?Functional analysis of optineurin and some of its disease-associated mutantsLoss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamicsOptineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutationA Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of OptineurinM98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cellsE50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy.Disruption of macrophage pro-inflammatory cytokine release in Crohn's disease is associated with reduced optineurin expression in a subset of patientsCommon and rare genetic risk factors for glaucoma.Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin gene.Optineurin regulates the interferon response in a cell cycle-dependent mannerIdentification of an Alu-repeat-mediated deletion of OPTN upstream region in a patient with a complex ocular phenotype.Optineurin: The autophagy connection.Ankyrin repeat and suppressor of cytokine signaling box containing protein-10 is associated with ubiquitin-mediated degradation pathways in trabecular meshwork cells.Making sense of the cause of Crohn's - a new look at an old disease.Effects of mutations and deletions in the human optineurin gene.Toward an integrative view of Optineurin functions.Genetics of primary open angle glaucoma.Interaction between optineurin and Rab1a regulates autophagosome formation in neuroblastoma cells.Working your SOCS off: The role of ASB10 and protein degradation pathways in glaucoma.A critical role of Hrd1 in the regulation of optineurin degradation and aggresome formation.Stepwise Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells Enables Analysis of Glaucomatous Neurodegeneration.Characterizing the "POAGome": A bioinformatics-driven approach to primary open-angle glaucoma.A yeast model of optineurin proteinopathy reveals a unique aggregation pattern associated with cellular toxicity.Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.Autophagy Dysregulation in ALS: When Protein Aggregates Get Out of Hand.From the Cover: Alterations in Optineurin Expression and Localization in Pre-clinical Parkinson's Disease ModelsExpression of optineurin isolated from rat-injured dental pulp and the effects on inflammatory signals in normal rat kidney cells.Enhanced optineurin E50K-TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma.661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively.The ubiquitin-proteasome system functionally links neuronal Tomosyn-1 to dendritic morphology.Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein.Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation.Genetics of glaucoma.Oligogenic inheritance of optineurin (OPTN) and C9ORF72 mutations in ALS highlights localisation of OPTN in the TDP-43-negative inclusions of C9ORF72-ALS.A recurrent G367R mutation in MYOC associated with juvenile open angle glaucoma in a large Chinese family.
P2860
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P2860
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Cellular and molecular biology of optineurin.
@en
type
label
Cellular and molecular biology of optineurin.
@en
prefLabel
Cellular and molecular biology of optineurin.
@en
P2860
P1476
Cellular and molecular biology of optineurin.
@en
P2093
Beatrice Y J T Yue
Hongyu Ying
P2860
P304
P356
10.1016/B978-0-12-394305-7.00005-7
P577
2012-01-01T00:00:00Z