Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging. - Wikidata - wikimedia - TriplyDB

Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging.

Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging.

http://www.wikidata.org/entity/Q33847654

about

Aging of hematopoietic stem cells: DNA damage and mutations?DNA Damage Response in Hematopoietic Stem Cell Ageing Reprogramming of energy metabolism as a driver of aging Genetic and Epigenetic Mechanisms That Maintain Hematopoietic Stem Cell Function When stem cells grow old: phenotypes and mechanisms of stem cell aging Fine-tuning the ubiquitin code at DNA double-strand breaks: deubiquitinating enzymes at work Age-dependent dysregulation of innate immunity Epigenetic regulation of hematopoietic stem cell aging Accumulation of DNA damage-induced chromatin alterations in tissue-specific stem cells: the driving force of aging?Adult stem cell and mesenchymal progenitor theories of aging.Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow Microenvironment Aging and radiation: bad companions Impact of genomic damage and ageing on stem cell function Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis Frequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during Aging Accumulation of DNA damage in the aged hematopoietic stem cell compartment Diffuse Large B-cell Lymphoma in the elderly: standard treatment and new perspectives.Association between telomere length and complete blood count in US adults.Molecular and phenotypic biomarkers of aging Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells.Stem cell aging: mechanisms, regulators and therapeutic opportunities.Beyond repair foci: DNA double-strand break repair in euchromatic and heterochromatic compartments analyzed by transmission electron microscopy.DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions.Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice Stable cellular senescence is associated with persistent DDR activation Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing.Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans.Do DNA Double-Strand Breaks Drive Aging?Regenerative capacity of old muscle stem cells declines without significant accumulation of DNA damage Role of reactive oxygen species in the radiation response of human hematopoietic stem/progenitor cells.X-ray induced formation of γ-H2AX foci after full-field digital mammography and digital breast-tomosynthesis.Concise review: hematopoietic stem cell aging and the prospects for rejuvenation Potential relationship between inadequate response to DNA damage and development of myelodysplastic syndrome.SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation.Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage.High throughput measurement of γH2AX DSB repair kinetics in a healthy human population DNA damage: a sensible mediator of the differentiation decision in hematopoietic stem cells and in leukemia.Similarities and differences between therapy-related and elderly acute myeloid leukemia.Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

P2860

Q26741217-66453DFC-5202-4265-80B2-F3D9EE93BD57 Q26746094-62FC0A95-C328-4D66-AAFB-175AB38D0307 Q26766053-D1F5805B-EA47-4950-965D-A9CE36661E7A Q26770001-BB448DA1-4881-4849-8E21-F9C0E185D666 Q26770845-FA9120CF-6B5E-4356-ABDA-EE7FEACF83B3 Q26781153-36935D58-EFD2-40AD-86E3-CAD8CDC157D5 Q27022410-184ACC06-B1D7-4B12-8C67-1365DCEC568D Q27026054-08BFF317-EE4D-4299-8EAC-E329F710F1D3 Q27319968-AC6DC30C-4691-4629-9321-EC80B2E96170 Q27690744-D4A48785-75BB-4852-8C46-19119E33465B Q28074446-D6DB680B-3C3E-4B2E-90AC-5EBE7A933F3C Q28082599-751DF573-56B5-41C5-90C6-D3521F054351 Q28308125-14C692C0-3C7A-474A-A231-FBE80C949768 Q28386212-8A42B261-DF0E-4032-B87E-C26CF0FF63F9 Q28395874-853B0697-AF0E-4279-87A8-98EC4E6D45E1 Q29248538-A86E44BA-98A4-47A3-9506-9E55530DA2F9 Q30235296-E4973B41-1164-4C29-BAF3-A616921B3647 Q33645982-0D8DAC54-7DE3-4B12-B6C1-6579E57EB8CE Q33806547-CA4B3B7D-7F66-4183-8ECB-C4B19BEED6D1 Q33849340-ACEE354E-A2D6-4678-9BA9-EAEB7EEFB18B Q34089181-315C4903-2A34-45BF-B47D-78748A91F615 Q34159765-72EACF4A-CA5A-42CF-AC3C-6BD2EB57FD89 Q34292873-4EF74A3E-F1B8-4BFA-A039-1BFA359542C5 Q34328242-79C16D36-CEF5-4931-8CD3-427E1DACC18E Q34348701-7D795189-34BA-424C-9DDC-0E08150B2E7A Q34395718-A2FCA951-1446-4706-B8D0-CFF496AA32F1 Q34470994-1477B63E-C8FB-4FA3-B1D2-9F2B256D3957 Q34533473-7799CB43-20C5-4746-8E74-8A8A4DD14EBD Q34539270-D8F08D43-7C72-4451-A594-19A7BE1BBD4C Q34737490-3BFDE09F-15B3-4265-8996-1EF7756A052E Q34923051-D8B00F29-F193-435D-895C-7B5C1C2EE218 Q34923353-D4F129EB-F51A-4D5B-BBC2-3A5BB8A35B6E Q35001363-F9F6432D-7AEF-48E4-A162-E35909AD0193 Q35016534-7EAE37DF-7920-4900-B520-1D92AF04693A Q35032227-1BF60C17-63F7-4FD8-96CB-44354D95D697 Q35192737-AB488358-1E5A-4536-9EFF-B95026BBEA6A Q35202869-30558758-7938-4A58-9897-4340815B2171 Q35381608-EDAF749D-4301-439E-BCA2-28F3C97EB597 Q35640731-195E7E49-1931-465C-AE72-EBA0DD074375 Q35684586-0749CD6B-0EDF-40FC-B441-AFC5EF7A0B11

P2860

Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging.

http://www.wikidata.org/entity/Q33847654

description

2011 nî lūn-bûn

@nan

2011 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի մարտին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging.

@ast

Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging.

@en

type

label

Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging.

@ast

Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging.

@en

prefLabel

Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging.

@ast

Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging.

@en

P1433

Q33847654-A2D630B4-7596-4112-92B5-0F714D237419

P1476

Q33847654-68E5FFF1-B02A-4841-9FCE-13D33D05E910

P2093

Q33847654-30095B9B-7239-416A-B71E-2DBA22453CE8

Q33847654-4A807BF4-7EC0-4794-98FF-36019E8A024A

Q33847654-9057A327-6AB3-4CB2-836B-DD73F3BBD37B

Q33847654-98B0FAFF-31D9-4D19-8721-72D476B6C901

Q33847654-BE4A08E3-AB18-421C-8D8C-6DBED2BD5674

Q33847654-E5E52B18-EA4F-411D-906F-C0D9627B9BF1

P2860

Q33847654-06F5A60A-1645-4F73-B38A-7C6172F98731

Q33847654-0F78F60F-E74A-4D04-8E21-A7796D66B893

Q33847654-10F909E8-43A8-476B-95C1-8E709D39AD7B

Q33847654-140CB78A-53A1-40BE-A096-9E8A760A5D1C

Q33847654-2143CA9F-9E80-45D4-8704-AFCD17B0C77C

Q33847654-215B2630-500B-4ACC-BFA4-2C92BBA732F8

Q33847654-27A6E5ED-8E2D-4F09-95E1-8AA99D01A971

Q33847654-2BDDB866-0160-40D9-AE6D-0D6EA6969EDF

Q33847654-2BDEB69E-976F-46B1-8404-3CE402B173BE

Q33847654-4044B1F4-3DE8-4632-8795-836F29D564F5

P304

Q33847654-EAFE0D06-5105-423C-89FA-8F087FC747AA

P31

Q33847654-A9B0A174-1C34-421E-99E7-FC670EF6D94B

P356

Q33847654-C235B65B-DC04-4B2F-8161-489D30E788A5

P407

Q33847654-6FC48A8E-269E-42B7-9549-08BCD534D81F

P433

Q33847654-B7D80EB6-5397-4A71-A93A-A4B33A1884C4

P478

Q33847654-8C69152D-AF83-49E8-BAFD-45AC599C67B5

P50

Q33847654-9F9E5EB2-61F0-4EC4-B99B-BD66B3503180

P577

Q33847654-2654AB00-5BDB-4306-839F-C74D1243F731

P5875

Q33847654-DFD8611B-76F8-4ED6-853B-2B9E9627EB3E

P698

Q33847654-278DC9B7-033F-48FE-9108-9C19C6F70609

P921

Q33847654-06F89EB5-6488-4D28-B5C1-91F6178ADE2A

P932

Q33847654-42004B94-5424-442E-9ACF-40224F919DD7

P356

JOURNAL.PONE.0017487

P1433

P1476

Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging.

@en

P2093

Andreas Fricke

http://www.w3.org/2001/XMLSchema#string

Christian Rübe

http://www.w3.org/2001/XMLSchema#string

Claudia E Rübe

http://www.w3.org/2001/XMLSchema#string

Henning Madry

http://www.w3.org/2001/XMLSchema#string

Thomas A Widmann

http://www.w3.org/2001/XMLSchema#string

Tobias Fürst

http://www.w3.org/2001/XMLSchema#string

P2860

DNA Damage, Aging, and Cancer

In vivo formation and repair of DNA double-strand breaks after computed tomography examinations

Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

Accumulation of senescent cells in mitotic tissue of aging primates

DNA repair is limiting for haematopoietic stem cells during ageing

Oxidative stress shortens telomeres

Lifestyle impacts on the aging-associated expression of biomarkers of DNA damage and telomere dysfunction in human blood

Telomere length measurement by fluorescence in situ hybridization and flow cytometry: tips and pitfalls.

Aging and replicative senescence have related effects on human stem and progenitor cells.

P304

e17487

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1371/JOURNAL.PONE.0017487

http://www.w3.org/2001/XMLSchema#string

P407

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

6

http://www.w3.org/2001/XMLSchema#string

P50

Michael Pfreundschuh

P577

2011-03-07T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

50400162

http://www.w3.org/2001/XMLSchema#string

P698

21408175

http://www.w3.org/2001/XMLSchema#string

P921

P932

3049780

http://www.w3.org/2001/XMLSchema#string