TDP-43 regulates Drosophila neuromuscular junctions growth by modulating Futsch/MAP1B levels and synaptic microtubules organization - Wikidata - wikimedia - TriplyDB

TDP-43 regulates Drosophila neuromuscular junctions growth by modulating Futsch/MAP1B levels and synaptic microtubules organization

TDP-43 regulates Drosophila neuromuscular junctions growth by modulating Futsch/MAP1B levels and synaptic microtubules organization

http://www.wikidata.org/entity/Q33849007

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The Presynaptic Microtubule Cytoskeleton in Physiological and Pathological Conditions: Lessons from Drosophila Fragile X Syndrome and Hereditary Spastic Paraplegias Neuroplasticity and Repair in Rodent Neurotoxic Models of Spinal Motoneuron Disease The Crossroads of Synaptic Growth Signaling, Membrane Traffic and Neurological Disease: Insights from Drosophila Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signaling Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43 Identification of genetic modifiers of TDP-43 neurotoxicity in Drosophila Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion.Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.Interactions between Tau and α-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease.Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS.Role of BMP receptor traffic in synaptic growth defects in an ALS model.Neuropathology of Amyotrophic Lateral Sclerosis and Its Variants.Futsch/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis.Opposing roles of p38 and JNK in a Drosophila model of TDP-43 proteinopathy reveal oxidative stress and innate immunity as pathogenic components of neurodegeneration.Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration.Altered mRNP granule dynamics in FTLD pathogenesis.Comparison of parallel high-throughput RNA sequencing between knockout of TDP-43 and its overexpression reveals primarily nonreciprocal and nonoverlapping gene expression changes in the central nervous system of Drosophila Glial TDP-43 regulates axon wrapping, GluRIIA clustering and fly motility by autonomous and non-autonomous mechanisms.Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons.Neurodegeneration the RNA way Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes Microtubule-associated protein 1B (MAP1B)-deficient neurons show structural presynaptic deficiencies in vitro and altered presynaptic physiology.RNA-binding proteins in neurodegenerative disease: TDP-43 and beyond.Evolutionarily conserved heterogeneous nuclear ribonucleoprotein (hnRNP) A/B proteins functionally interact with human and Drosophila TAR DNA-binding protein 43 (TDP-43).Tar DNA-binding protein-43 (TDP-43) regulates axon growth in vitro and in vivo TDP-43 autoregulation: implications for disease.RNA-binding proteins and translational regulation in axons and growth cones.Emerging roles for hnRNPs in post-transcriptional regulation: what can we learn from flies?Fishing for causes and cures of motor neuron disorders.The Role of TDP-43 in Alzheimer's Disease.Tyrosine kinase inhibition reverses TDP-43 effects on synaptic protein expression, astrocytic function and amino acid dis-homeostasis.Physiological functions and pathobiology of TDP-43 and FUS/TLS proteins.TDP-43 regulates the microprocessor complex activity during in vitro neuronal differentiation.Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?TDP-43 and Cytoskeletal Proteins in ALS.High-content RNAi screening identifies the Type 1 inositol triphosphate receptor as a modifier of TDP-43 localization and neurotoxicity.TDP-43 in the spectrum of MND-FTLD pathologies.Novel Mechanisms of Spinal Cord Plasticity in a Mouse Model of Motoneuron Disease.Reduced TDP-43 Expression Improves Neuronal Activities in a Drosophila Model of Perry Syndrome.

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TDP-43 regulates Drosophila neuromuscular junctions growth by modulating Futsch/MAP1B levels and synaptic microtubules organization

http://www.wikidata.org/entity/Q33849007

description

2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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TDP-43 regulates Drosophila ne ...... ptic microtubules organization

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TDP-43 regulates Drosophila ne ...... ptic microtubules organization

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JOURNAL.PONE.0017808

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TDP-43 regulates Drosophila ne ...... ptic microtubules organization

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P2093

Chiara Appocher

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Fabian Feiguin

http://www.w3.org/2001/XMLSchema#string

Francisco E Baralle

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Raffaella Klima

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Vinay K Godena

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P2860

Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping

Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function

TDP-43-mediated neuron loss in vivo requires RNA-binding activity

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9

HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo

Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

A Drosophila model for TDP-43 proteinopathy.

Disruption of the MAP1B-related protein FUTSCH leads to changes in the neuronal cytoskeleton, axonal transport defects, and progressive neurodegeneration in Drosophila

Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS).

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10.1371/JOURNAL.PONE.0017808

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3

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6

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Emanuele Buratti

Maurizio Romano

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2011-03-11T00:00:00Z

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50409961

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21412434

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3055892

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