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Inside out: the role of nucleocytoplasmic transport in ALS and FTLDPathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disordersThe ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth.Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.Targeting RNA binding proteins involved in neurodegeneration.HIV-1 replication in human immune cells is independent of TAR DNA binding protein 43 (TDP-43) expression.Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALSDistinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses.Increased cytoplasmic TARDBP mRNA in affected spinal motor neurons in ALS caused by abnormal autoregulation of TDP-43A nonsense mutation in mouse Tardbp affects TDP43 alternative splicing activity and causes limb-clasping and body tone defects.Early Cognitive/Social Deficits and Late Motor Phenotype in Conditional Wild-Type TDP-43 Transgenic Mice.Principles of self-organization in biological pathways: a hypothesis on the autogenous association of alpha-synucleinWorming forward: amyotrophic lateral sclerosis toxicity mechanisms and genetic interactions in Caenorhabditis elegans.Predominance of spliceosomal complex formation over polyadenylation site selection in TDP-43 autoregulation.Stress granules at the intersection of autophagy and ALS.TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathwaysDisease-associated mutations of TDP-43 promote turnover of the protein through the proteasomal pathway.Characterizing TDP-43 interaction with its RNA targets.Autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay.The proteinopathy of D169G and K263E mutants at the RNA Recognition Motif (RRM) domain of tar DNA-binding protein (tdp43) causing neurological disorders: A computational study.
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P2860
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 18 June 2011
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
TDP-43 autoregulation: implications for disease.
@en
TDP-43 autoregulation: implications for disease.
@nl
type
label
TDP-43 autoregulation: implications for disease.
@en
TDP-43 autoregulation: implications for disease.
@nl
prefLabel
TDP-43 autoregulation: implications for disease.
@en
TDP-43 autoregulation: implications for disease.
@nl
P2860
P1476
TDP-43 autoregulation: implications for disease.
@en
P2093
Mauricio Budini
P2860
P2888
P304
P356
10.1007/S12031-011-9573-8
P577
2011-06-18T00:00:00Z