Trypanothione is the primary target for arsenical drugs against African trypanosomes.
about
Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosomeTwo interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug designDissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methodsTrypanothione-dependent glyoxalase I in Trypanosoma cruziRecent developments in drug discovery for leishmaniasis and human African trypanosomiasisPathways of As(III) detoxification in Saccharomyces cerevisiae.Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stressDrug resistance in eukaryotic microorganisms.Hydrogen peroxide-mediated toxicity for Leishmania donovani chagasi promastigotes. Role of hydroxyl radical and protection by heat shock.Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis.Contribution of dithiol ligands to in vitro and in vivo trypanocidal activities of dithiaarsanes and investigation of ligand exchange in an aqueous solutionCombination chemotherapy of drug-resistant Trypanosoma brucei rhodesiense infections in mice using DL-alpha-difluoromethylornithine and standard trypanocides.Glutathionylspermidine metabolism in Escherichia coli. Purification, cloning, overproduction, and characterization of a bifunctional glutathionylspermidine synthetase/amidase.Genetic dissection of drug resistance in trypanosomesMobilization of mercury and arsenic in humans by sodium 2,3-dimercapto-1-propane sulfonate (DMPS)Antiparasitic chemotherapy: from genomes to mechanisms.Differential susceptibility to DL-alpha-difluoromethylornithine in clinical isolates of Trypanosoma brucei rhodesiense.Human African trypanosomiasis of the CNS: current issues and challengesQuinol derivatives as potential trypanocidal agentsPeroxiredoxins in parasites.Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomesAdenosine kinase of Trypanosoma brucei and its role in susceptibility to adenosine antimetabolites.Trypanosome Lytic Factor-1 Initiates Oxidation-stimulated Osmotic Lysis of Trypanosoma brucei brucei.Human African trypanosomiasis: pharmacological re-engagement with a neglected disease.Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story.Engineering the substrate specificity of glutathione reductase toward that of trypanothione reductionTrypanocidal drugs: mechanisms, resistance and new targets.Emerging trends in the diagnosis of human African Trypanosomiasis.Novel biochemical pathways in parasitic protozoa.Biomedical science and the third world. Under the volcano. Trypanothione reductase.High-throughput decoding of antitrypanosomal drug efficacy and resistance.Properties of melarsamine hydrochloride (Cymelarsan) in aqueous solution.A Platform for the Detection of Trypanosomes via Selective Small Molecule Recognition.In vitro antileishmanial properties of tri- and pentavalent antimonial preparations.Arsthinol nanosuspensions: pharmacokinetics and anti-leukaemic activity on NB4 promyelocytic leukaemia cells.Antitumor quinol PMX464 is a cytocidal anti-trypanosomal inhibitor targeting trypanothione metabolism.Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase of Trypanosoma brucei.Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase.Metal Ions Effectively Ablate the Action of Botulinum Neurotoxin A.A glutaredoxin in the mitochondrial intermembrane space has stage-specific functions in the thermo-tolerance and proliferation of African trypanosomes.
P2860
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P2860
Trypanothione is the primary target for arsenical drugs against African trypanosomes.
description
1989 nî lūn-bûn
@nan
1989 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Trypanothione is the primary target for arsenical drugs against African trypanosomes.
@ast
Trypanothione is the primary target for arsenical drugs against African trypanosomes.
@en
type
label
Trypanothione is the primary target for arsenical drugs against African trypanosomes.
@ast
Trypanothione is the primary target for arsenical drugs against African trypanosomes.
@en
prefLabel
Trypanothione is the primary target for arsenical drugs against African trypanosomes.
@ast
Trypanothione is the primary target for arsenical drugs against African trypanosomes.
@en
P2093
P2860
P356
P1476
Trypanothione is the primary target for arsenical drugs against African trypanosomes.
@en
P2093
A H Fairlamb
G B Henderson
P2860
P304
P356
10.1073/PNAS.86.8.2607
P407
P577
1989-04-01T00:00:00Z