Functional characterization of vasopressin type 2 receptor substitutions (R137H/C/L) leading to nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis: implications for treatments.

Functional characterization of vasopressin type 2 receptor substitutions (R137H/C/L) leading to nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis: implications for treatments.

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http://www.wikidata.org/entity/Q33862041

Q33862041

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Pharmacological chaperoning: a primer on mechanism and pharmacology Altered agonist sensitivity of a mutant v2 receptor suggests a novel therapeutic strategy for nephrogenic diabetes insipidus.Biased signaling favoring gi over β-arrestin promoted by an apelin fragment lacking the C-terminal phenylalanine Oxytocin and vasopressin agonists and antagonists as research tools and potential therapeutics.The μ-opioid receptor variant N190K is unresponsive to peptide agonists yet can be rescued by small-molecule drugs.Enhanced BRET Technology for the Monitoring of Agonist-Induced and Agonist-Independent Interactions between GPCRs and β-Arrestins Signaling Modification by GPCR Heteromer and Its Implication on X-Linked Nephrogenic Diabetes Insipidus.Identification and characterization of an activating F229V substitution in the V2 vasopressin receptor in an infant with NSIAD.Nephrogenic diabetes insipidus: essential insights into the molecular background and potential therapies for treatment.Functional polymorphisms affecting the clinically important arginine-137 residue of AVPR2 do not influence serum sodium concentration at the population level Mutations of Vasopressin Receptor 2 Including Novel L312S Have Differential Effects on Trafficking.Familial forms of diabetes insipidus: clinical and molecular characteristics.Nephrogenic syndrome of inappropriate antidiuresis secondary to an activating mutation in the arginine vasopressin receptor AVPR2.V2 vasopressin receptor (V2R) mutations in partial nephrogenic diabetes insipidus highlight protean agonism of V2R antagonists.Characterization of three vasopressin receptor 2 variants: an apparent polymorphism (V266A) and two loss-of-function mutations (R181C and M311V)Genetic variants affecting equivalent protein family positions reflect human diversity.Lack of responsiveness to 1-desamino-D arginin vasopressin (desmopressin) in male patients with nephrogenic syndrome of inappropriate antidiuresis: from bench to bedside.Hereditary Nephrogenic Diabetes Insipidus: Pathophysiology and Possible Treatment. An Update.GPCR Retreat 2012: timing is everything.

P2860

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P2860

Functional characterization of vasopressin type 2 receptor substitutions (R137H/C/L) leading to nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis: implications for treatments.

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http://www.wikidata.org/entity/Q33862041

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2010 nî lūn-bûn

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2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2010 թվականի փետրվարին հրատարակված գիտական հոդված

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2010年の論文

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