Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus - Wikidata - wikimedia - TriplyDB

Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus

Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus

http://www.wikidata.org/entity/Q34584278

about

The melanosomal/lysosomal protein OA1 has properties of a G protein-coupled receptor Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network The chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, β-arrestin-mediated internalization Structural and functional impairment of endocytic pathways by retinitis pigmentosa mutant rhodopsin-arrestin complexes Heterodimerization of V1a and V2 vasopressin receptors determines the interaction with beta-arrestin and their trafficking patterns Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor The structural basis of arrestin-mediated regulation of G-protein-coupled receptors A rapid and affordable screening platform for membrane protein trafficking.RNA editing induces variation in desensitization and trafficking of 5-hydroxytryptamine 2c receptor isoforms Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1 A Single Amino Acid Mutation (R104P) in the E/DRY Motif of GPR40 Impairs Receptor Function Altered agonist sensitivity of a mutant v2 receptor suggests a novel therapeutic strategy for nephrogenic diabetes insipidus.Functional characterization of vasopressin type 2 receptor substitutions (R137H/C/L) leading to nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis: implications for treatments.Beyond desensitization: physiological relevance of arrestin-dependent signaling.beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6.Quality control for unfolded proteins at the plasma membrane.G Protein and β-arrestin signaling bias at the ghrelin receptor.G-protein-coupled receptors for neurotransmitter amino acids: C-terminal tails, crowded signalosomes.Phenotypic regulation of the sphingosine 1-phosphate receptor miles apart by G protein-coupled receptor kinase 2.The stem cell-expressed receptor Lgr5 possesses canonical and functionally active molecular determinants critical to β-arrestin-2 recruitment.Visualizing microtubule-dependent vasopressin type 2 receptor trafficking using a new high-affinity fluorescent vasopressin ligand.G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs).Engagement of β-arrestin by transactivated insulin-like growth factor receptor is needed for V2 vasopressin receptor-stimulated ERK1/2 activation.Enhanced BRET Technology for the Monitoring of Agonist-Induced and Agonist-Independent Interactions between GPCRs and β-Arrestins The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.Signaling Modification by GPCR Heteromer and Its Implication on X-Linked Nephrogenic Diabetes Insipidus.Desensitization of herpesvirus-encoded G protein-coupled receptors.Function of non-visual arrestins in signaling and endocytosis of the gastrin-releasing peptide receptor (GRP receptor).Engineering visual arrestin-1 with special functional characteristics Functional polymorphisms affecting the clinically important arginine-137 residue of AVPR2 do not influence serum sodium concentration at the population level Therapeutic potential of β-arrestin- and G protein-biased agonists.The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors Common structural requirements for heptahelical domain function in class A and class C G protein-coupled receptors.Triphenylmethane dye activation of beta-arrestin Mutations of Vasopressin Receptor 2 Including Novel L312S Have Differential Effects on Trafficking.Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption.Agonist-independent interactions between beta-arrestins and mutant vasopressin type II receptors associated with nephrogenic syndrome of inappropriate antidiuresis.Characterization of relaxin receptor (RXFP1) desensitization and internalization in primary human decidual cells and RXFP1-transfected HEK293 cells Paracrine transactivation of the CB1 cannabinoid receptor by AT1 angiotensin and other Gq/11 protein-coupled receptors The effect of aspartate-lysine-isoleucine and aspartate-arginine-tyrosine mutations on the expression and activity of vasopressin V2 receptor gene.

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Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus

http://www.wikidata.org/entity/Q34584278

description

2001 nî lūn-bûn

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2001 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2001 թվականի հունվարին հրատարակված գիտական հոդված

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2001年の論文

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2001年学术文章

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2001年学术文章

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2001年学术文章

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name

Constitutive arrestin-mediated ...... nephrogenic diabetes insipidus

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Constitutive arrestin-mediated ...... nephrogenic diabetes insipidus

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Constitutive arrestin-mediated ...... nephrogenic diabetes insipidus

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Constitutive arrestin-mediated ...... nephrogenic diabetes insipidus

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Constitutive arrestin-mediated ...... nephrogenic diabetes insipidus

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Constitutive arrestin-mediated ...... nephrogenic diabetes insipidus

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Proceedings of the National Academy of Sciences of the United States of America

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Constitutive arrestin-mediated ...... nephrogenic diabetes insipidus

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L S Barak

http://www.w3.org/2001/XMLSchema#string

M G Caron

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R H Oakley

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S A Laporte

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P2860

The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis

Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants

The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits

A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation

Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family

Role of phosphorylation in agonist-promoted beta 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by beta ARK1

Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor

Using green fluorescent proteins to study G-protein-coupled receptor localization and trafficking.

Constitutively active mutants of rhodopsin.

Constitutive activation of phototransduction by K296E opsin is not a cause of photoreceptor degeneration.

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93-98

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10.1073/PNAS.011303698

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