ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.
about
Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replicationThe dictyostelium kinome--analysis of the protein kinases from a simple model organism.Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replicationSIRT1 regulates the function of the Nijmegen breakage syndrome proteinRAD50 and NBS1 form a stable complex functional in DNA binding and tetheringA supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damageReleasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaksDynamics of DNA damage response proteins at DNA breaks: a focus on protein modificationsEmerging common themes in regulation of PIKKs and PI3KsThe Knowns Unknowns: Exploring the Homologous Recombination Repair Pathway in Toxoplasma gondiiATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to AdaptorStructure of a Second BRCT Domain Identified in the Nijmegen Breakage Syndrome Protein Nbs1 and its Function in an MDC1-Dependent Localization of Nbs1 to DNA Damage SitesMre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break RepairNbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and RepairγH2A binds Brc1 to maintain genome integrity during S-phaseATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complexMre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repairStructure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signalingATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signalingTel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repairMRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length controlSpatial organization of the mammalian genome surveillance machinery in response to DNA strand breaksNuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cellsChk2 suppresses the oncogenic potential of DNA replication-associated DNA damageTel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand BreaksRare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening studyATR: an essential regulator of genome integrityStructures of closed and open conformations of dimeric human ATMIdentification of Plasmodium falciparum DNA Repair Protein Mre11 with an Evolutionarily Conserved Nuclease FunctionNuclear export of NBN is required for normal cellular responses to radiationThe FHA domain determines Drosophila Chk2/Mnk localization to key mitotic structures and is essential for early embryonic DNA damage responses.A novel mouse model for ataxia-telangiectasia with a N-terminal mutation displays a behavioral defect and a low incidence of lymphoma but no increased oxidative burden.The involvement of ataxia-telangiectasia mutated protein activation in nucleotide excision repair-facilitated cell survival with cisplatin treatment.Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection.The Mre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells.Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombinationMultiple autophosphorylation sites are dispensable for murine ATM activation in vivoDifferential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres.
P2860
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P2860
ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
ATM activation and its recruit ...... ing to the C terminus of Nbs1.
@ast
ATM activation and its recruit ...... ing to the C terminus of Nbs1.
@en
type
label
ATM activation and its recruit ...... ing to the C terminus of Nbs1.
@ast
ATM activation and its recruit ...... ing to the C terminus of Nbs1.
@en
prefLabel
ATM activation and its recruit ...... ing to the C terminus of Nbs1.
@ast
ATM activation and its recruit ...... ing to the C terminus of Nbs1.
@en
P2093
P2860
P1476
ATM activation and its recruit ...... ing to the C terminus of Nbs1.
@en
P2093
Charly Chahwan
Julie Bailis
Paul Russell
Tony Hunter
Zhongsheng You
P2860
P304
P356
10.1128/MCB.25.13.5363-5379.2005
P407
P577
2005-07-01T00:00:00Z