Disabled-2 inactivation is an early step in ovarian tumorigenicity. - Wikidata - wikimedia - TriplyDB

Disabled-2 inactivation is an early step in ovarian tumorigenicity.

Disabled-2 inactivation is an early step in ovarian tumorigenicity.

http://www.wikidata.org/entity/Q33863070

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The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway.The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2 Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT)Dab2 links CIN85 with clathrin-mediated receptor internalization Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport Early events in ovarian oncogenesis DAB2IP in cancer Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice Cell cycle-dependent phosphorylation of Disabled-2 by cdc2 Disabled-2 is transcriptionally regulated by ICSBP and augments macrophage spreading and adhesion.Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2 Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2 The inhibitory role of DOC-2/DAB2 in growth factor receptor-mediated signal cascade. DOC-2/DAB2-mediated inhibition of ERK phosphorylation via binding to Grb2 Characterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancer Type II transforming growth factor-beta receptor recycling is dependent upon the clathrin adaptor protein Dab2 p67 isoform of mouse disabled 2 protein acts as a transcriptional activator during the differentiation of F9 cells Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations A single common portal for clathrin-mediated endocytosis of distinct cargo governed by cargo-selective adaptors.Sulfatides partition disabled-2 in response to platelet activation.Transcription profiles of non-immortalized breast cancer cell lines.Xenopus Dab2 is required for embryonic angiogenesis Dynamic expression of Dab2 in the mouse embryonic central nervous system.Loss of GATA4 and GATA6 expression specifies ovarian cancer histological subtypes and precedes neoplastic transformation of ovarian surface epithelia Putative tumour-suppressor gene DAB2 is frequently down regulated by promoter hypermethylation in nasopharyngeal carcinoma.Ovarian cancer: pathology, biology, and disease models Restoration of positioning control following Disabled-2 expression in ovarian and breast tumor cells.Loss of disabled-2 expression is an early event in esophageal squamous tumorigenesis.Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.Epigenetic regulation of a novel tumor suppressor gene (hDAB2IP) in prostate cancer cell lines.Regulation of ovarian cancer progression by microRNA-187 through targeting Disabled homolog-2.Lessons from border cell migration in the Drosophila ovary: A role for myosin VI in dissemination of human ovarian cancer.Hormonal induction and roles of Disabled-2 in lactation and involution.Vitamin D transport proteins megalin and disabled-2 are expressed in prostate and colon epithelial cells and are induced and activated by all-trans-retinoic acid miR-93-directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer.Differential requirement for Dab2 in the development of embryonic and extra-embryonic tissues.Loss of Dab2 expression in breast cancer cells impairs their ability to deplete TGF-β and induce Tregs development via TGF-β.Identification of genes differentially expressed in myogenin knock-down bovine muscle satellite cells during differentiation through RNA sequencing analysis.Dab2, a negative regulator of DC immunogenicity, is an attractive molecular target for DC-based immunotherapy.Disabled-2 heterozygous mice are predisposed to endometrial and ovarian tumorigenesis and exhibit sex-biased embryonic lethality in a p53-null background Invasion of normal human fibroblasts induced by v-Fos is independent of proliferation, immortalization, and the tumor suppressors p16INK4a and p53.

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Disabled-2 inactivation is an early step in ovarian tumorigenicity.

http://www.wikidata.org/entity/Q33863070

description

1999 nî lūn-bûn

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1999 թուականի Մայիսին հրատարակուած գիտական յօդուած

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1999 թվականի մայիսին հրատարակված գիտական հոդված

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1999年の論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年论文

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name

Disabled-2 inactivation is an early step in ovarian tumorigenicity.

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Disabled-2 inactivation is an early step in ovarian tumorigenicity.

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type

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Disabled-2 inactivation is an early step in ovarian tumorigenicity.

@ast

Disabled-2 inactivation is an early step in ovarian tumorigenicity.

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prefLabel

Disabled-2 inactivation is an early step in ovarian tumorigenicity.

@ast

Disabled-2 inactivation is an early step in ovarian tumorigenicity.

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Disabled-2 inactivation is an early step in ovarian tumorigenicity.

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Cohen C

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Fazili Z

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Mittelstaedt S

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P2860

Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2

DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer

Mouse disabled (mDab1): a Src binding protein implicated in neuronal development

Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains

Orientation of peptide fragments from Sos proteins bound to the N-terminal SH3 domain of Grb2 determined by NMR spectroscopy

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

Antioncogenes and human cancer.

Aberrant splicing of a mouse disabled homolog, mdab1, in the scrambler mouse

Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice

Neuronal position in the developing brain is regulated by mouse disabled-1

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