Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer - Wikidata - wikimedia - TriplyDB

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

http://www.wikidata.org/entity/Q33865946

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Coordinated silencing of MYC-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-Cell lymphomas ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma A small-cell lung cancer genome with complex signatures of tobacco exposure Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers International network of cancer genome projects.A decade of exploring the cancer epigenome - biological and translational implications Dissecting the genomic complexity underlying medulloblastoma The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset Initial genome sequencing and analysis of multiple myeloma State of the science: an update on renal cell carcinoma Hyperexpansion of GAA repeats affects post-initiation steps of FXN transcription in Friedreich's ataxia Regulation of chromatin by histone modifications Epigenetic modulators, modifiers and mediators in cancer aetiology and progression Targeting EZH2 in cancer Mutation of chromatin modifiers; an emerging hallmark of germinal center B-cell lymphomas Combating the epigenome: epigenetic drugs against non-Hodgkin's lymphoma Mechanisms of epigenetic regulation of leukemia onset and progression Recent progress toward epigenetic therapies: the example of mixed lineage leukemia Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention Myeloid malignancies: mutations, models and management The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation.IDH2R172 mutations define a unique subgroup of patients with angioimmunoblastic T-cell lymphoma.Novel therapeutic strategies for multiple myeloma EZH2 in Bladder Cancer, a Promising Therapeutic Target The roles of chromatin-remodelers and epigenetic modifiers in kidney cancer JMJD3 as an epigenetic regulator in development and disease Deletion of KDM6A, a histone demethylase interacting with MLL2, in three patients with Kabuki syndrome Histone methylation: a dynamic mark in health, disease and inheritance The histone demethylase UTX enables RB-dependent cell fate control The genetic landscape of the childhood cancer medulloblastoma Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization Female bias in Rhox6 and 9 regulation by the histone demethylase KDM6A Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

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Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

http://www.wikidata.org/entity/Q33865946

description

2009 nî lūn-bûn

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2009 թուականի Մարտին հրատարակուած գիտական յօդուած

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2009 թվականի մարտին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

@zh-hk

2009年論文

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2009年論文

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2009年论文

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name

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

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Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

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type

label

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

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Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

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prefLabel

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

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Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

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Nature Genetics

P1476

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

@en

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Aaron Massie

http://www.w3.org/2001/XMLSchema#string

Adam Butler

http://www.w3.org/2001/XMLSchema#string

Catherine Leroy

http://www.w3.org/2001/XMLSchema#string

Chai Yin Kok

http://www.w3.org/2001/XMLSchema#string

Chris Greenman

http://www.w3.org/2001/XMLSchema#string

Claire Hardy

http://www.w3.org/2001/XMLSchema#string

Dave Beare

http://www.w3.org/2001/XMLSchema#string

David J McBride

http://www.w3.org/2001/XMLSchema#string

David Jones

http://www.w3.org/2001/XMLSchema#string

Erin Pleasance

http://www.w3.org/2001/XMLSchema#string

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Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth.

Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases

Chromatin modifications and their function

UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

A histone H3 lysine 27 demethylase regulates animal posterior development

Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer

An X chromosome gene, WTX, is commonly inactivated in Wilms tumor.

The UTX gene escapes X inactivation in mice and humans.

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.

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10.1038/NG.349

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5

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41

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Tatiana Mironenko

Jennifer Varian

Gijs van Haaften

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2009-03-29T00:00:00Z

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24242499

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1001520036

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19330029

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2873835

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