Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.
about
DUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic TargetsExploiting the Fanconi Anemia Pathway for Targeted Anti-Cancer TherapyDeubiquitinating enzymes as oncotargetsAllosteric Activation of Ubiquitin-Specific Proteases by β-Propeller Proteins UAF1 and WDR20ID1 promotes breast cancer metastasis by S100A9 regulation.Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer.Screening of DUB activity and specificity by MALDI-TOF mass spectrometryCheminformatics models based on machine learning approaches for design of USP1/UAF1 abrogators as anticancer agents.ID proteins regulate diverse aspects of cancer progression and provide novel therapeutic opportunities.Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell StemnessRegulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression.Ubiquitin-Specific Proteases as Druggable Targets.A novel role for the deubiquitinase USP1 in the control of centrosome duplication.The isopeptidase inhibitor 2cPE triggers proteotoxic stress and ATM activation in chronic lymphocytic leukemia cells.In vivo genome-wide binding of Id2 to E2F4 target genes as part of a reversible program in mice liver.Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer.DUBs, the regulation of cell identity and disease.Counteracting PINK/Parkin Deficiency in the Activation of Mitophagy: A Potential Therapeutic Intervention for Parkinson's Disease.Decision for cell fate: deubiquitinating enzymes in cell cycle checkpoint.Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models.Ubiquitin-specific protease 39 is overexpressed in human lung cancer and promotes tumor cell proliferation in vitro.Chemical and semisynthetic approaches to study and target deubiquitinases.Targeting Deubiquitinating Enzymes in Glioblastoma Multiforme: Expectations and Challenges.Cell Lysate-Based AlphaLISA Deubiquitinase Assay Platform for Identification of Small Molecule Inhibitors.Mutations in the 'Fingers' subdomain of the deubiquitinase USP1 modulate its function and activity.Structure-function analysis of USP1: insights into the role of Ser313 phosphorylation site and the effect of cancer-associated mutations on autocleavage.Identification of deubiquitinase targets of isothiocyanates using SILAC-assisted quantitative mass spectrometry.DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway.Targeting deubiquitinating enzymes in cancer stem cells.Metal-based proteasomal deubiquitinase inhibitors as potential anticancer agents.Blockade of Deubiquitylating Enzyme USP1 Inhibits DNA Repair and Triggers Apoptosis in Multiple Myeloma Cells.The novel anti-androgen candidate galeterone targets deubiquitinating enzymes, USP12 and USP46, to control prostate cancer growth and survival.Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewalRare Genetic Diseases with Defects in DNA Repair: Opportunities and Challenges in Orphan Drug Development for Targeted Cancer Therapy
P2860
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P2860
Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.
description
2013 nî lūn-bûn
@nan
2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.
@ast
Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.
@en
type
label
Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.
@ast
Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.
@en
prefLabel
Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.
@ast
Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.
@en
P2093
P2860
P1476
Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells
@en
P2093
Alan D D'Andrea
Eunmi Park
Grace Hsieh
Gregory D Cuny
Helena Mistry
Ilene Galinsky
Kalindi Parmar
Nathanael S Gray
Richard M Stone
Sara J Buhrlage
P2860
P304
P356
10.1158/1535-7163.MCT-13-0103-T
P50
P577
2013-10-15T00:00:00Z