Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes - Wikidata - wikimedia - TriplyDB

Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes

Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes

http://www.wikidata.org/entity/Q33874248

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The Crosstalk between Hypoxia and Innate Immunity in the Development of Obesity-Related Nonalcoholic Fatty Liver Disease Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved?Hypoxia-regulated mechanisms in the pathogenesis of obesity and non-alcoholic fatty liver disease.Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue Human high-altitude adaptation: forward genetics meets the HIF pathway.Conditional knockout of prolyl hydroxylase domain protein 2 attenuates high fat-diet-induced cardiac dysfunction in mice.The contributions of HIF-target genes to tumor growth in RCC.Partial depletion of yolk during zebrafish embryogenesis changes the dynamics of methionine cycle and metabolic genes Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle.Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis Maladaptive Modulations of NLRP3 Inflammasome and Cardioprotective Pathways Are Involved in Diet-Induced Exacerbation of Myocardial Ischemia/Reperfusion Injury in Mice.Adipocyte-Specific Hypoxia-Inducible Factor 2α Deficiency Exacerbates Obesity-Induced Brown Adipose Tissue Dysfunction and Metabolic Dysregulation HIF2α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling.Overexpression of miR-223 Tips the Balance of Pro- and Anti-hypertrophic Signaling Cascades toward Physiologic Cardiac Hypertrophy.Inhibition of PHD3 by salidroside promotes neovascularization through cell-cell communications mediated by muscle-secreted angiogenic factors.VEGF-targeted cancer therapeutics-paradoxical effects in endocrine organs.HIF prolyl hydroxylase PHD3 regulates translational machinery and glucose metabolism in clear cell renal cell carcinoma.Role of Intestinal HIF-2α in Health and Disease.Hypoxia in Obesity and Diabetes: Potential Therapeutic Effects of Hyperoxia and Nitrate.Role of prolyl hydroxylase domain proteins in the regulation of insulin secretion.IRS proteins and diabetic complications.The role of HIFs in ischemia-reperfusion injury.Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism.Transcriptome analysis of severe hypoxic stress during development in zebrafish.Hypoxia-inducible factor prolyl hydroxylase 1 (PHD1) deficiency promotes hepatic steatosis and liver-specific insulin resistance in mice.Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27.Selective inhibition of the hypoxia-inducible factor prolyl hydroxylase PHD3 by Zn(II).Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression.Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling.Long-range hypoxia signaling in NAFLD.Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-κB and p53 signaling pathways.Elevating VEGF-A and PDGF-BB secretion by salidroside enhances neoangiogenesis in diabetic hind-limb ischemia.PRMT1 promotes hyperglycemia in a FoxO1-dependent manner, affecting glucose metabolism, during hypobaric hypoxia exposure, in rat model.Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis.Hypoxia-Inducible Factor and Its Role in the Management of Anemia in Chronic Kidney Disease.RASAL1 inhibits HepG2 cell growth via HIF-2α mediated gluconeogenesis.Metabolic implications of hypoxia and pseudohypoxia in pheochromocytoma and paraganglioma.Acute systemic insulin intolerance does not alter the response of the Akt/GSK-3 pathway to environmental hypoxia in human skeletal muscle.A central role for hypoxia-inducible factor (HIF)-2α in hepatic glucose homeostasis.

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Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes

http://www.wikidata.org/entity/Q33874248

description

2013 nî lūn-bûn

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2013 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2013 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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Nature Medicine

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Cross-talk between hypoxia and ...... olism and ameliorates diabetes

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Amato J Giaccia

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Anh N Diep

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Calvin J Kuo

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Colleen Wu

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Edward L LaGory

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Elizabeth C Finger

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Jenny Yuan

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Kevin Wei

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Lisa M McGinnis

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P2860

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice.

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Critical nodes in signalling pathways: insights into insulin action

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism

Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo

The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO.

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1325-1330

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10.1038/NM.3294

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Cullen M Taniguchi

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256611508

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24037093

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